Results 61 to 70 of about 129,353 (325)
Advanced Science, 2023 Amino acids (AAs) and ammonia are metabolic markers essential for nitrogen metabolism and cell regulation in both plants and humans. NMR provides interesting opportunities to investigate these metabolic pathways, yet lacks sensitivity, especially in case
Ewoud Vaneeckhaute +4 more
doaj +1 more source
Interfacing Liquid State Hyperpolarization Methods with NMR Instrumentation
Journal of Magnetic Resonance Open, 2022 Advances in liquid state hyperpolarization methods have enabled new applications of high-resolution NMR spectroscopy. Utilizing strong signal enhancements from hyperpolarization allows performing NMR spectroscopy at low concentration, or with high time ...
Pierce Pham +3 more
doaj +1 more source
Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Unlike most other voltage-activated ion channels, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels open in response to hyperpolarizing membrane voltages.
G. Flynn, W. N. Zagotta
semanticscholar +1 more source
Toward C13 hyperpolarized biomarkers produced by thermal mixing with hyperpolarized X129e [PDF]
The Journal of Chemical Physics, 2009 The C13 NMR signal of acetic acid 1-C13-AcH is enhanced by polarization transfer from hyperpolarized X129e using a thermal mixing procedure. 1-C13-AcH acid and hyperpolarized X129e are mixed as gases to disperse X129e in the acetic acid. The mixture is frozen with liquid N2 at 0.5 T.
Natalia, Lisitza +5 more
openaire +2 more sources
The journal of physical chemistry. C, Nanomaterials and interfaces, 2017 Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR hyperpolarization method that uses cheap and readily available para-hydrogen as a hyperpolarization source. SABRE can hyperpolarize protons and heteronuclei.
J. Colell +10 more
semanticscholar +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Journal of Biological Dynamics, 2021 The dynamic mechanism of a whole-cell model containing electrical signalling and two-compartment Ca $ ^{2+} $ signalling in gonadotrophs is investigated.
Xiaowen Xiong, Yanqiu Li, Dongmei Zheng
doaj +1 more source
Synthetic Studies Toward ［1-13C］Pyruvate
Journal of Isotopes, 2023 Magnetic resonance imaging (MRI) is limited in clinical application due to its low sensitivity. Hyperpolarization technology overcomes this limitation by enhancing molecular MRI signal.
QING Jing;JIA Xuelei;CHEN Kai;DAI Desheng;LI Guowei
doaj +1 more source
Effects of methamphetamine on locomotor activity and thalamic gene expression in leptin-deficient obese mice [PDF]
, 2017 Leptin is an adipose-derived hormone that regulates energy balance. Leptin receptors are expressed in extrahypothalamic sites and several reports showed that leptin can influence feeding and locomotor behavior via direct actions on dopaminergic neurons ...
Bisagno, Veronica +3 more
core +2 more sources
Nanodiamond-enhanced MRI via in situ hyperpolarization
Nature Communications, 2017 Nanodiamonds are of interest as nontoxic substrates for targeted drug delivery and as highly biostable fluorescent markers for cellular tracking. Beyond optical techniques, however, options for noninvasive imaging of nanodiamonds in vivo are severely ...
D. Waddington +10 more
semanticscholar +1 more source