Results 71 to 80 of about 108,295 (308)

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source

Application of Ultrasound Elastography in Assessing Portal Hypertension

Diagnostics, 2022
Portal hypertension is a common manifestation in late-to-end-stage liver diseases and can cause severe complications such as ascites, hepatic encephalopathy, etc.
Man Zhang, Hongyu Jin, Jiazhi Cao, Ruyu Ren, Menglu Jia, Yi Yang, Xinyi Li, Ming Chen, Shen Li, Libin Huang, Wenwu Ling   +10 more
doaj   +1 more source

Emerging non-invasive approaches for diagnosis and monitoring of portal hypertension. [PDF]

, 2018
Clinically significant portal hypertension is associated with an increased risk of developing gastro-oesophageal varices and hepatic decompensation.
Berzigotti, Annalisa, Sarin, Shiv Kumar, Cardenas, Andres, Qi, Xiaolong   +3 more
core   +1 more source

Pregnancy with extrahepatic portal venous hypertension [PDF]

, 2021
We are reporting a case of pregnancy with extrahepatic portal venous hypertension. Portal hypertension in pregnancy is an uncommon event. It presents a challenge to the obstetrician in management as physiological hemodynamic changes associated with ...
S., Sapna I., Nabapure, Shilpa, Sai, Balumuri Pooja   +2 more
core   +2 more sources

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

Features of encephalopathy diagnosis in patients with portal hypertension syndrome

Gastroenterologìa, 2017
Background. Hepatic encephalopathy is a pathological change in the brain functions of non-inflammatory origin, which is manifested by a syndrome of secondary neurological and cognitive disorders caused by a set of deep metabolic disorders, as a result of
Yu.M. Stepanov, N.V. Chaliy, S.L. Меlanich   +2 more
doaj   +1 more source

Portal‐hypertensive gastropathy

Journal of Gastroenterology and Hepatology, 1998
ABSTRACTIn the present article we describe updated information concerning the clinical feature of portal‐hypertensive gastropathy (PHG), which is characterized by mucosal and submucosal vascular dilatation without inflammation. Although this lesion represents non‐variceal bleeding, there is a wide variation of its prevalence.
TOYONAGA, Atsushi, IWAO, Tadashi
openaire   +3 more sources

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Noninvasive Evaluation of Portal Hypertension: Emerging Tools and Techniques

International Journal of Hepatology, 2012
Portal hypertension is the main cause of complications in patients with cirrhosis. However, evaluating the development and progression of portal hypertension represents a challenge for clinicians.
V. K. Snowdon, N. Guha, J. A. Fallowfield   +2 more
doaj   +1 more source