Results 61 to 70 of about 9,287,329 (300)

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Association Between Preoperative Steroid Use and Short‐Term Outcomes Following Pancreaticoduodenectomy: A Nationwide Analysis Using the National Clinical Database

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Pancreaticoduodenectomy (PD) carries a high risk of postoperative complications. Although steroids are widely prescribed for various chronic diseases, the specific impact after PD remains unclear. This study evaluated the association between preoperative chronic steroid use and short‐term outcomes following PD.
Yoshito Tomimaru, Hideki Endo, Hiroyuki Yamamoto, Teruhide Ishigame, Hideki Ueno, Ken Shirabe, Hidetoshi Eguchi   +6 more
wiley   +1 more source

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Non-invasive assessment and prediction of clinically significant portal hypertension

, 2011
Hepatic venous pressure gradient (HVPG) predicts variceal development, bleeding, clinical decompensation and death. Measurement is invasive, time-consuming and performed in few centres.
Austin, Andrew, K. Rye, A. Austin, Freeman, Jan G., J. Freeman, G. Mortimore, Rye, Kara, Mortimore, Gerri   +7 more
core   +1 more source

COLOURDOPPLER AND ULTRASONOGRAPHIC EVALUATION OF PORTAL HYPERTENSION

, 2023
Introduction:An accurate non-invasive method of determining the cause, degree, and problems of portal hypertension is ultrasound doppler. Using ultrasonic Doppler, the varied spectrum of results, flow metric variations, and portosystemic collaterals may ...
Rama Krishna Rao Baru, Sankeerthy Redd, P. Durga Prasad, Bhargav Reddy Gummalla   +3 more
core   +1 more source

TTC21B: From Modifier to Causative Gene in Joubert Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic pathogenic variants in TTC21B, encoding the retrograde intraflagellar transport protein IFT139, are a known cause of renal and skeletal ciliopathies. Single heterozygous variants in this gene were found to be enriched in a cohort of patients with various ciliopathy phenotypes, including three individuals with Joubert syndrome (JS), a
Valentina Serpieri, Fulvio D'Abrusco, Anna Pichiecchio, Thouraya Ben Younes, Ichraf Kraoua, Enza Maria Valente   +5 more
wiley   +1 more source

Features of encephalopathy diagnosis in patients with portal hypertension syndrome

Gastroenterologìa, 2017
Background. Hepatic encephalopathy is a pathological change in the brain functions of non-inflammatory origin, which is manifested by a syndrome of secondary neurological and cognitive disorders caused by a set of deep metabolic disorders, as a result of
Yu.M. Stepanov, N.V. Chaliy, S.L. Меlanich   +2 more
doaj   +1 more source

Application of Ultrasound Elastography in Assessing Portal Hypertension

Diagnostics, 2022
Portal hypertension is a common manifestation in late-to-end-stage liver diseases and can cause severe complications such as ascites, hepatic encephalopathy, etc.
Man Zhang, Hongyu Jin, Jiazhi Cao, Ruyu Ren, Menglu Jia, Yi Yang, Xinyi Li, Ming Chen, Shen Li, Libin Huang, Wenwu Ling   +10 more
doaj   +1 more source

Posterosuperior and Anterior Rotator Cuff Repairs Yield Comparable 1‐Year Constant Scores in Routine Clinical Practice: A Propensity Score‐Matched Study From LaTour Group

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To compare clinical outcomes and ultrasound‐assessed healing rates between posterosuperior and anterior rotator cuff repairs using propensity score matching. Methods Consecutive patients undergoing rotator cuff repair between 2015 and 2021 by a single fellowship‐trained shoulder surgeon were included if they had posterosuperior or anterior ...
Mustafa S. Rashid, Hugo Bothorel, Alberto Guizzi, Philippe Collin, Arash Amiri, Jeanni Zbinden, Alexandre Lädermann   +6 more
wiley   +1 more source

Portal‐hypertensive gastropathy

Journal of Gastroenterology and Hepatology, 1998
ABSTRACTIn the present article we describe updated information concerning the clinical feature of portal‐hypertensive gastropathy (PHG), which is characterized by mucosal and submucosal vascular dilatation without inflammation. Although this lesion represents non‐variceal bleeding, there is a wide variation of its prevalence.
TOYONAGA, Atsushi, IWAO, Tadashi
openaire   +3 more sources