Results 121 to 130 of about 2,219,611 (304)
Management of pulmonary hypertension
South African Medical Journal, 2015 Pulmonary arterial hypertension (PAH) is a potentially lethal disease mainly affecting young females. Although the precise mechanism of PAH is unknown, the past decade has seen the advent of many new classes of drugs with improvement in the overall prognosis of the disease.
Umesh G. Lalloo +9 more
openaire +6 more sources
Advanced Science, EarlyView.CD19‐293‐EV can switch the CD19 endocytosis pathway from clathrin‐mediated endocytosis to aggregation‐dependent endocytosis, leading to lysosomal degradation of the CD19/EVs complex. Degradation of the EVs leads to impairment in the IFN response and enhancement in EV uptake by target cells, creating a potent feedback cycle.
Zixuan Huang +17 more
wiley +1 more source
HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension
Scientific Reports, 2017 Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with limited therapeutic options. Although exposed to stressful conditions, pulmonary artery (PA) smooth muscle cells (PASMCs) exhibit a “cancer-like” pro-proliferative and anti ...
Olivier Boucherat +13 more
doaj +1 more source
The Mechanism and Potential Therapeutic Strategies of Vascular Aging
AGING MEDICINE, EarlyView.The phenotypes of vascular aging vary across different blood vessels. Endothelial dysfunction is observable in the endothelium of all vessels, while vascular structural remodeling primarily occurs in arteries. A decline in organ vascular density mainly affects arterioles, venules, and capillaries, whereas thrombosis predominantly occurs in the ...
Wan‐Zhou Wu +4 more
wiley +1 more source
Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism
Pulmonary CirculationAlthough current guidelines recommend standard cardiopulmonary exercise testing (CPET) to evaluate symptomatic patients after pulmonary embolism (PE), CPET with simultaneous echocardiography could provide relevant information to evaluate right ...
Karys Khilzi +11 more
doaj +1 more source
AGING MEDICINE, EarlyView.This graphic summary shows the main clinical outcomes of patients over 80 years of age following pancreaticoduodenectomy (PD) after adjusting for propensity score weighting (IPTW). Compared with younger patients, there was no significant difference in postoperative complication rates or overall survival time in elders. ABSTRACT Objectives With an aging
Tianxiao Wang +9 more
wiley +1 more source
Pulmonary vascular disease, environmental pollution, and climate change
Pulmonary CirculationPollution and climate change constitute a combined, grave and pervasive threat to humans and to the life‐support systems on which they depend. Evidence shows a strong association between pollution and climate change on cardiovascular and respiratory ...
Mona Lichtblau +2 more
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.This multicenter cohort study of 8782 esophagectomies in Japan found that higher intraoperative fluid volume significantly increased the risk of pneumonia after minimally invasive esophagectomy. Avoiding fluid overload may help reduce postoperative pneumonia.
Akihiko Okamura +8 more
wiley +1 more source
Ischemia-reperfusion injury with a model of porcine whole-blood ex-vivo lung perfusion
Frontiers in TransplantationIntroductionOur objective was to model Ischemia-Reperfusion (IR) injuries by ex-vivo perfusion of porcine lungs with whole blood containing the inflammatory cells.MethodsLungs and whole blood were collected from 12 pigs and submitted to cold ischemia ...
Jean-Baptiste Menager +23 more
doaj +1 more source
Pulmonary Circulation, 2019 Atrial septal defect (ASD) is one of the most frequent congenital heart diseases (CHD). Up to 10% of adults with an ASD develop pulmonary arterial hypertension (PAH, PAH-CHD) in their lifetime.
Christopher Hohmann +5 more
doaj +1 more source