Results 41 to 50 of about 349,993 (124)
A Systems Engineering Approach to Modeling and Analysis of Chronic Obstructive Pulmonary Disease (COPD) [PDF]
arXiv, 2022 Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease characterized by airflow limitation. This study develops a systems engineering framework for representing important mechanistic details of COPD in a model of the cardio-respiratory system.
arxiv
Efficient Uncertainty Quantification in a Multiscale Model of Pulmonary Arterial and Venous Hemodynamics [PDF]
arXiv, 2023 Computational hemodynamics models are becoming increasingly useful in the management and prognosis of complex, multiscale pathologies, including those attributed to the development of pulmonary vascular disease. However, diseases like pulmonary hypertension are heterogeneous, and affect both the proximal arteries and veins as well as the ...
arxiv
Pulmonary Circulation, 2021 Pulmonary hypertension is a progressive cardiorespiratory disease that is characterized by considerable morbidity and mortality. While physical activity can improve symptoms and quality of life, engagement in this population is suboptimal.
Ciara McCormack +7 more
doaj +1 more source
Hemodynamic assessment of pulmonary hypertension in mice: a model based analysis of the disease mechanism [PDF]
arXiv, 2017 This study uses a one dimensional fluid dynamics arterial network model to infer changes in hemodynamic quantities associated with pulmonary hypertension in mice. Data for this study include blood flow and pressure measurements from the main pulmonary artery for 7 control mice with normal pulmonary function and 5 hypertensive mice with hypoxia induced ...
arxiv
Computer simulation of surgical interventions for the treatment of refractory pulmonary hypertension [PDF]
arXiv, 2021 This paper describes computer models of three interventions used for treating refractory pulmonary hypertension (RPH). These procedures create either an atrial septal defect, a ventricular septal defect, or, in the case of a Potts shunt, a patent ductus arteriosus.
arxiv
Prediction of Prognostic Hemodynamic Indices in Pulmonary Hypertension Using Non-Invasive Parameters
Diagnostics, 2020 Effective targeted therapy of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) requires regular risk stratification.
Rafał Mańczak +7 more
doaj +1 more source
Arthritis Research & TherapyBackground In the EDITA trial, patients with systemic sclerosis (SSc) and mild pulmonary vascular disease (PVD) treated with ambrisentan had a significant decline of pulmonary vascular resistance (PVR) but not of mean pulmonary arterial pressure (mPAP ...
Panagiota Xanthouli +10 more
doaj +1 more source
DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells
Physiological Reports, 2019 Nitric Oxide (NO) is an endogenous pulmonary vasodilator produced by endothelial NO synthase (eNOS). Asymmetric dimethyl L‐arginine (ADMA) is an endogenous inhibitor of eNOS activity.
Jennifer K. Trittmann +3 more
doaj +1 more source
Pulmonary CirculationThe aim of this single‐centre retrospective observational study was to evaluate the safety, tolerability, and efficacy of an in‐class combination therapy switch from bosentan plus sildenafil to ambrisentan plus tadalafil in children with pulmonary ...
Cara Morgan +7 more
doaj +1 more source
Patient engagement and self-management in pulmonary arterial hypertension
European Respiratory Review, 2016 Improved care in pulmonary arterial hypertension has led to increased longevity for patients, with a paralleled evolution in the nature of their needs.
Jytte Graarup +2 more
doaj +1 more source