Results 61 to 70 of about 1,434,677 (298)

Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Ellen Romich, Alexis Ogdie, Alisa Stephens Shields, Peter A. Merkel, Shervin Assassi, Elana J. Bernstein, Andreea Bujor, Flavia V. Castelino, Lorinda Chung, Luke B. Evnin, Tracy M. Frech, Jessica K. Gordon, Melissa Griffith, Faye N. Hant, Monica L. Harding, Laura K. Hummers, Dinesh Khanna, Kimberly S. Lakin, Dorota J. Lebiedz‐Odrobina, Yiming Luo, Ashima Makol, Maureen D. Mayes, Zsuzsanna H. McMahan, Jerry Molitor, Duncan F. Moore, Julie Paik, Carrie Richardson, Brian Skaug, Ami A. Shah, Ankoor Shah, Virginia Steen, John M. VanBuren, Elizabeth R. Volkmann, Carleigh Zahn, Nora Sandorfi, for the CONQUER Investigators   +35 more
wiley   +1 more source

Apelin and Pulmonary Hypertension [PDF]

Pulmonary Circulation, 2011
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by pulmonary vasoconstriction, pulmonary arterial remodeling, abnormal angiogenesis and impaired right ventricular function. Despite progress in pharmacological therapy, there is still no cure for PAH.
Andersen, Charlotte Uggerhøj, Hilberg, Ole, Mellemkjær, Søren, Nielsen-Kudsk, Jens E, Simonsen, U; id_orcid 0000-0002-2169-7666   +4 more
openaire   +2 more sources

Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy [PDF]

, 2017
Pulmonary arterial hypertension (PAH) is a progressive and debilitating condition. Despite promoting vasodilation, current drugs have a therapeutic window within which they are limited by systemic side effects.
Lickiss, PD, Barreira, B, Mitchell, JA, Kirkby, NS, Reed, DM, Ahmetaj-Shala, B, Freeman, GR, Yacoub, MH, Mohamed, NA, Morales-Cano, D, Chester, AH, Saleem, H, Tetley, TD, Gashaw, HH, Moreno, L, Davies, RP, Wort, SJ, George, PM, Freeman, Gemma R, Peter M. George, Paul D. Lickiss, Hime H. Gashaw, Wort, Stephen J, Yacoub, Magdi H, Saleem, Hira, George, Peter M, Kirkby, Nicholas S, Adrian H. Chester, Mohamed, Nura A, Ahmetaj-Shala, Blerina, Morales-Cano, Daniel, Blerina Ahmetaj‐Shala, Barreira, Bianca, Nura A. Mohamed, Laura Moreno, Lickiss, Paul D, Daniel Morales‐Cano, Daniel M. Reed, Davies, Robert P, Gashaw, Hime H, Stephen J. Wort, Gemma R. Freeman, Moreno, Laura, Robert P. Davies, Jane A. Mitchell, Reed, Daniel M, Mitchell, Jane A, Teresa D. Tetley, Chester, Adrian H, Hira Saleem, Magdi H. Yacoub, Tetley, Teresa D, Bianca Barreira, Nicholas S. Kirkby   +53 more
core   +1 more source

Health Care Use Among Patients Presenting to Emergency Department for Gout Flares in Ontario, Canada: A Population‐Based Health Systems Analysis

Arthritis Care &Research, EarlyView.
Objective We characterized emergency department (ED) gout visits and identified patient characteristics and health services patterns contributing to ED presentations. Methods We conducted a population‐based study of ED gout visits in Ontario, Canada, between 2014 and 2023.
Timothy S. H. Kwok, Samantha Morais, William K. Silverstein, Clare L. Atzema, Gregory Choy, Priyanka Chandratre, Ping Li, Jessica Widdifield   +7 more
wiley   +1 more source

Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis

Canadian Respiratory Journal, 2017
Background. Recent studies have reported that obstructive sleep apnea (OSA) patients present alterations in right ventricular (RV) structure and function. However, large randomized controlled trials evaluating the impact of OSA on the right ventricle are
Abdirashit Maripov, Argen Mamazhakypov, Meerim Sartmyrzaeva, Almaz Akunov, Kubatbek Muratali uulu, Melis Duishobaev, Meerim Cholponbaeva, Akylbek Sydykov, Akpay Sarybaev   +8 more
doaj   +1 more source

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

Arthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa, Yicheng Mu, Marie Hudson, Janet Pope   +3 more
wiley   +1 more source

Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood

, 2021
Idiopathic pulmonary arterial hypertension (IPAH) is a rare but fatal disease diagnosed by right heart catheterisation and the exclusion of other forms of pulmonary arterial hypertension, producing a heterogeneous population with varied treatment ...

core   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Significance of echocardiographic metrics including TRV and TAPSE/SPAP in mild haemodynamic pulmonary hypertension – data from EVIDENCE-PAH UK

Echo Research and Practice
Background The 2022 ESC/ERS guidelines redefined pulmonary hypertension (PH) as a mean pulmonary artery pressure (mPAP) >20 mmHg on right heart catheterisation (RHC).
Nina Karia, Daniel Murphy, Luke Howard, Martin Johnson, David G. Kiely, James Lordan, Colm McCabe, Joanna Pepke-Zaba, Daniel Knight, Vivek Muthurangu, J. Gerry Coghlan   +10 more
doaj   +1 more source

Noninvasive diagnostic modalities and prediction models for detecting pulmonary hypertension associated with interstitial lung disease: a narrative review

European Respiratory Review
Pulmonary hypertension (PH) is highly prevalent in patients with interstitial lung disease (ILD) and is associated with increased morbidity and mortality.
Alexandra Arvanitaki, Gerhard Paul Diller, Michael A. Gatzoulis, Colm McCabe, Laura C. Price, S. John Wort   +5 more
doaj   +1 more source