Results 71 to 80 of about 1,434,677 (298)

Advancing Clinical Trial Design in Pulmonary Hypertension [PDF]

, 2013
In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare ...
D. Dunbar Ivy, Shen Xiao, Hsien Ming J. Hung, Xiao, Shen, Shien‐Chung Chow, Noreen R. Henig, Kawut, Steven M, Hung, Hsien Ming J, Grieve, Andy P, Stephen Dawe, Dawe, Stephen, Harnisch, Lutz O, Chow, Shien-Chung, Andy P. Grieve, Lutz O. Harnisch, Henig, Noreen R, Rahbar, Mohammad H, Steven M. Kawut, John Curram, Mohammad H. Rahbar, Curram, John, Ivy, D Dunbar, Wilkins, Martin R, Martin R. Wilkins   +23 more
core   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

Pulmonary hypertension

Jornal Brasileiro de Pneumologia, 2023
Edson Marchiori1, Bruno Hochhegger2, Gláucia Zanetti1   +2 more
openaire   +5 more sources

Reduced gastrointestinal iron uptake in pulmonary arterial hypertension: a prospective cross-sectional study

Respiratory Research
Background Iron deficiency (ID) is common in patients with pulmonary arterial hypertension (PAH) and is associated with worse clinical outcomes. The etiology of ID in PAH is poorly understood. The aim of this study was to systematically determine whether
Luisa Repsold, Satenik Harutyunova, Ekkehard Grünig, Nicola Benjamin, Panagiota Xanthouli, Benjamin Egenlauf, Andreea Florea, Memoona Shaukat, Richard Sparla, Christina Mertens, Martina U. Muckenthaler, Christina A. Eichstaedt   +11 more
doaj   +1 more source

Left main bronchus compression due to main pulmonary artery dilatation in pulmonary hypertension: two case reports [PDF]

, 2015
Pulmonary arterial dilatation associated with pulmonary hypertension may result in significant compression of local structures. Left main coronary artery and left recurrent laryngeal nerve compression have been described.
Declan P. O'Regan, Gin-Sing, W, Ben Ariff, Wendy Gin‐Sing, Davies, R, Rachel Davies, Jaijee, SK, Gibbs, JS, Shareen K. Jaijee, J. Simon R. Gibbs, Howard, L, Ariff, B, Luke Howard, O'Regan, DP   +13 more
core   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Differences in health policies for drug availability in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension across Latin America

, 2022
Treatment for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension in Latin America differs between countries, with regard to disease etiology, health insurance coverage, and drug availability.
Rafael Conde, Restrepo‐Jaramillo, Ricardo, Cáneva, Jorge, Mauricio Orozco‐Levi, Luciano Melatini, Orozco‐Levi, Mauricio, Jorge Cáneva, Diez, Mirta, Mirta Diez, Tomás Pulido, Valdéz, Héctor, Manuel C. Pacheco Gallego, Nayeli Zayas, Ricardo Restrepo‐Jaramillo, Carlos Jardim, Melatini, Luciano, Jardim, Carlos, Pacheco-Gallego, Manuel C., Caio Fernandes, Fernandes, Caio, Pacheco Gallego, Manuel C., Héctor Valdéz, Zayas, Nayeli, Conde, Rafael, Pulido, Tomás   +24 more
core   +1 more source

Determinants of Body Mass Index in Early Systemic Sclerosis: Implications for Nutritional Risk Stratification

Arthritis Care &Research, EarlyView.
Objective Gastrointestinal (GI) involvement can lead to malnutrition in patients with systemic sclerosis (SSc). Body mass index (BMI) remains the most widely used marker to screen nutritional status. We aimed to identify predictors of lower BMI in patients with SSc. Methods Patients with SSc from a prospective US cohort meeting 2013 American College of
Ali Y. Ayla, Meng Zhang, Bingrui Chen, Claudia Pedroza, Brian Skaug, Maureen Mayes, Michael Hughes, Shervin Assassi, Zsuzsanna H. McMahan   +8 more
wiley   +1 more source

Tadalafil in patients with chronic obstructive pulmonary disease:a randomised, double-blind, parallel-group, placebo-controlled trial [PDF]

, 2014
Background: Phosphodiesterase-5 (PDE5) inhibitors improve exercise capacity and quality of life in patients with idiopathic pulmonary arterial hypertension.
Lipworth, Brian J., Struthers, Allan D., Hopkinson, Pippa J., Goudie, Andrew R., Wei, Li   +4 more
core   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source