Results 41 to 50 of about 1,353,360 (263)

Early treatment with ambrisentan of mildly elevated mean pulmonary arterial pressure associated with systemic sclerosis: a randomized, controlled, double-blind, parallel group study (EDITA study)

Arthritis Research & Therapy, 2019
Objective The objective of this randomized, placebo-controlled, double-blind, parallel group, trial was to assess the effect of ambrisentan on mean pulmonary arterial pressure (mPAP) in patients with systemic sclerosis (SSc) and mildly elevated pulmonary
Zixuan Pan, Alberto M. Marra, Nicola Benjamin, Christina A. Eichstaedt, Norbert Blank, Eduardo Bossone, Antonio Cittadini, Gerry Coghlan, Christopher P. Denton, Oliver Distler, Benjamin Egenlauf, Christine Fischer, Satenik Harutyunova, Panagiota Xanthouli, Hanns-Martin Lorenz, Ekkehard Grünig   +15 more
doaj   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Pulmonary hypertension

, 2015
Pulmonary hypertension (PH) is a haemodynamic condition that leads to a progressive increase in pulmonary vascular resistance and mean pulmonary artery pressure.
Vonk Noordegraaf, Anton, van der Bruggen, Cathelijne E. E., Spruijt, Onno A., Meijboom, Lilian J.   +3 more
core   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Ellen Romich, Alexis Ogdie, Alisa Stephens Shields, Peter A. Merkel, Shervin Assassi, Elana J. Bernstein, Andreea Bujor, Flavia V. Castelino, Lorinda Chung, Luke B. Evnin, Tracy M. Frech, Jessica K. Gordon, Melissa Griffith, Faye N. Hant, Monica L. Harding, Laura K. Hummers, Dinesh Khanna, Kimberly S. Lakin, Dorota J. Lebiedz‐Odrobina, Yiming Luo, Ashima Makol, Maureen D. Mayes, Zsuzsanna H. McMahan, Jerry Molitor, Duncan F. Moore, Julie Paik, Carrie Richardson, Brian Skaug, Ami A. Shah, Ankoor Shah, Virginia Steen, John M. VanBuren, Elizabeth R. Volkmann, Carleigh Zahn, Nora Sandorfi, for the CONQUER Investigators   +35 more
wiley   +1 more source

Right Heart Size and Right Ventricular Reserve in Pulmonary Hypertension: Impact on Management and Prognosis

Diagnostics, 2020
Various parameters reflecting right heart size, right ventricular function and capacitance have been shown to be prognostically important in patients with pulmonary hypertension (PH).
Ekkehard Grünig, Christina A. Eichstaedt, Rebekka Seeger, Nicola Benjamin   +3 more
doaj   +1 more source

The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension. [PDF]

, 2018
Chronic thromboembolic pulmonary hypertension (CTEPH) is an important consequence of pulmonary embolism that is associated with abnormalities in haemostasis.
Newnham, Michael; id_orcid, Ng, Choo, Laffan, Michael, Jenkins, David, Wharton, John, Trembath, Richard C, Villar, Sofia S., Newnham, Michael, Howard, Luke S., South, Kieron; id_orcid, Morrell, Nicholas W, Gräf, Stefan, Pepke-Zaba, Joanna, Barberà, Joan, Screaton, Nicholas, Su, Li, Villar, Sofia S, Simpson, Michael A, Cannon, John E., Bogaard, Harm, Rhodes, Christopher J, Wilkins, Martin R., Cannon, John E, Trembath, Richard C., Auger, William, Pepe-Zaba, Joanna, Lane, David A., Bunclark, Katherine, Lane, David, Auger, William R., Barberà, Joan A., Morrell, Nicholas W., Rhodes, Christopher J., Mayer, Eckhard, Southwood, Mark, Lane, David A, Trembath, Richard, Simpson, Michael, Toshner, Mark, Bleda, Marta, Sheares, Karen, Cannon, John, Barberà, Joan A, South, Kieron, Morrell, Nicholas, Hadinnapola, Charaka, Howard, Luke S, Taboada, Dolores, Rhodes, Christopher, Delcroix, Marion, Auger, William R, Villar, Sofia, Howard, Luke, Traylor, Matthew, Simpson, Michael A., Wilkins, Martin, Wilkins, Martin R   +56 more
core   +3 more sources

Dynamic vascular changes in chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy [PDF]

, 2020
Residual pulmonary hypertension is an important sequela after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. Recurrent thrombosis or embolism could be a contributor to this residual pulmonary hypertension but the potential ...
Symersky, Petr, Braams, N.J., Bogaard, Harm Jan, Lely, R.J., Boonstra, Anco, Lely, Rutger J., Klok, Frederikus A., Lilian J. Meijboom, Frederikus A. Klok, Braams, Natalia J., Bogaard, Harm-Jan, Bonta, P.I., Nossent, E.J., Vonk Noordegraaf, Anton, Nossent, Esther J., Ruigrok, Dieuwertje, Meijboom, Lilian J., Natalia J. Braams, Meijboom, L.J., Dieuwertje Ruigrok, Anton Vonk Noordegraaf, Harm‐Jan Bogaard, Esther J. Nossent, Symersky, P., Anco Boonstra, Peter I. Bonta, Bogaard, H.J., Ruigrok, D., Noordegraaf, A.V., Bonta, Peter I., Boonstra, A., Klok, F.A., Rutger J. Lely, Petr Symersky   +33 more
core   +1 more source