Results 101 to 110 of about 2,534,413 (315)

Respiratory sympathetic modulation is augmented in chronic kidney disease [PDF]

Respiratory Physiology and Neurobiology, Elsevier, In press, 2019
Respiratory modulation of sympathetic nerve activity (respSNA) was studied in a hypertensive rodent model of chronic kidney disease (CKD) using Lewis Polycystic Kidney (LPK) rats and Lewis controls. In adult animals under in vivo anaesthetised conditions (n=8-10/strain), respiratory modulation of splanchnic and renal nerve activity was compared under ...
arxiv  

Multi-scale Multi-site Renal Microvascular Structures Segmentation for Whole Slide Imaging in Renal Pathology [PDF]

arXiv, 2023
Segmentation of microvascular structures, such as arterioles, venules, and capillaries, from human kidney whole slide images (WSI) has become a focal point in renal pathology. Current manual segmentation techniques are time-consuming and not feasible for large-scale digital pathology images.
arxiv  

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Blood pressure response to renal denervation is correlated with baseline blood pressure variability: a patient-level meta-analysis [PDF]

, 2018
Background: Sympathetic tone is one of the main determinants of blood pressure (BP) variability and treatment-resistant hypertension. The aim of our study was to assess changes in BP variability after renal denervation (RDN).
Berra, Elena, Blankestijn, Peter J., Bots, Michiel L., Burnier, Michel, Czarnecka, Danuta, de Jong, Mark R., Elvan, Arif, Fadl Elmula, Fadl Elmula M., Gordin, Daniel, Jacobs, Lotte, Kahan, Thomas, Kjeldsen, Sverre E., Mark, Patrick B., Miroslawska, Atena, Olszanecka, Agnieszka, Persu, Alexandre, Renkin, Jean, Rosa, Ján, Spaak, Jonas, Spiering, Wilko, Staessen, Jan A., Steigen, Terje K., Taylor, Alison H.M., the European Network COordinating research on Renal Denervation (ENCOReD), Thijs, Lutgarde, Tikkanen, Ilkka, Widimský, Jiří, Wuerzner, Gregoire   +27 more
core   +2 more sources

Quantifying and Estimating the Predictive Accuracy for Censored Time-to-Event Data with Competing Risks [PDF]

arXiv, 2017
This paper focuses on quantifying and estimating the predictive accuracy of prognostic models for time-to-event outcomes with competing events. We consider the time-dependent discrimination and calibration metrics, including the receiver operating characteristics curve and the Brier score, in the context of competing risks.
arxiv  

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Bladder stone: “Must know” ultrasonographic signs

Clinical Case Reports, 2019
Key Clinical Message Point‐of‐care ultrasonography by non‐radiology physicians has become a valuable bedside diagnostic tool. As urolithiasis is one of the commonest indications for sonographic examination, physicians need to be familiar with the ...
Abhilash Koratala, Ananthalaxmi Vangapalli, Deepti Bhattacharya, Justin Lee Loy   +3 more
doaj   +1 more source

Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet [PDF]

, 2017
AIM:To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS:Sprague-Dawley rats were fed with 8% NaCl high-salt (HS) or 0.4% NaCl ...
Cao, Gabriel Fernando, Choi, Marcelo Roberto, Della Penna, Silvana Lorena, Fernandez, Belisario Enrique, Gorzalczany, Susana Beatriz, Kouyoumdzian, Nicolás Martín, Roson, Maria Ines, Toblli, Jorge Eduardo   +7 more
core   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Causal Models for Estimating the Effects of Weight Gain on Mortality [PDF]

arXiv, 2008
Suppose, contrary to fact, in 1950, we had put the cohort of 18 year old non-smoking American men on a stringent mandatory diet that guaranteed that no one would ever weigh more than their baseline weight established at age 18. How would the counter-factual mortality of these 18 year olds have compared to their actual observed mortality through 2007 ...
arxiv