Results 31 to 40 of about 1,479,001 (304)

Renal impairment in a rural African antiretroviral programme [PDF]

, 2009
Background: There is little knowledge regarding the prevalence and nature of renal impairment in African populations initiating antiretroviral treatment, nor evidence to inform the most cost effective methods of screening for renal impairment.
Till Barnighausen, Cooke, GS, Barnighausen, Till, Cara Franey, Lessells, RJ, Newell, Marie-Louise, Knott, Deborah, Franey, C, Dedicoat Martin, Dedicoat, Martin, Newell Marie-Louise, Adam, A, Deborah Knott, Martin Dedicoat, Knott, D, Adam, Ahmed, Ahmed Adam, Newell, M-L, Franey, Cara, Lessells Richard J, Adam Ahmed, Richard J Lessells, Cooke Graham S, Marie-Louise Newell, Cooke, Graham S, Barnighausen Till, Lessells, Richard J, Dedicoat, M, Graham S Cooke, Knott Deborah, Barnighausen, T, Franey Cara   +31 more
core   +2 more sources

Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury [PDF]

, 2012
The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between ...
Ryan, Michael P., Johnston, Olwyn, Slattery, Craig, Cassidy, Hilary, McMorrow, Tara   +4 more
core   +2 more sources

An 88‐year‐old patient with ADPKD: underscoring the importance of risk factor modification

Clinical Case Reports, 2017
Key Clinical Message The mean age of onset of end‐stage renal disease (ESRD) in autosomal dominant polycystic kidney disease (ADPKD) is between 56 and 69.
Abhilash Koratala, Freddy R Malpartida, Amir Kazory   +2 more
doaj   +1 more source

Know your patients’ history; spleno-renal infarction as a presentation of infective endocarditis

Clinics and Practice, 2017
Bacterial endocarditis is an infection of the endothelial surface of the heart, including heart valves and is potentially life threatening. Antibiotic prophylaxis is indicated prior to invasive procedures in patients with certain high-risk cardiac ...
Abhilash Koratala, Muhannad Leghrouz, Volodymyr Chornyy   +2 more
doaj   +1 more source

Metformin does not slow cyst growth in the PCK rat model of polycystic kidney disease

Physiological Reports, 2023
Metformin (MET) has the potential to activate p‐AMPK and block mTORC1‐induced proliferation of tubular cells in PKD kidneys. The aim of this study was to determine the effects of MET on cyst growth, kidney function, AMPK and mTOR signaling, and lactate ...
Ozgur A. Oto, Daniel J. Atwood, Anjana Chaudhary, Zhibin He, Amy S. Li, Michael F. Wempe, Charles L. Edelstein   +6 more
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration

Nature Communications, 2022
After acute injury, kidneys either successfully repair/regenerate or become fibrotic. Here the authors use scRNA-seq to study adaptive/maladaptive kidney regeneration and identify proinflammatory/fibrotic proximal tubule cells with pharmacologically ...
Michael S. Balzer, Tomohito Doke, Ya-Wen Yang, Daniel L. Aldridge, Hailong Hu, Hung Mai, Dhanunjay Mukhi, Ziyuan Ma, Rojesh Shrestha, Matthew B. Palmer, Christopher A. Hunter, Katalin Susztak   +11 more
doaj   +1 more source

Myogenic constriction in renal failure : cause and therapy [PDF]

, 2012
In bloeddruk regulerende vaten, de zogenaamde weerstandsvaten, wordt myogene constrictie geactiveerd door verhoogde transmurale druk. De verhoogde transmurale druk zorgt voor contractie van het arteriële gladde spierweefsel, met vernauwing van het lumen ...
Vavrinec, Peter,, Vavrinec, Peter
core  

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 [PDF]

, 1999
Deficiency of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia ...
Mullins, A J, Edwards, Christopher R. W., Seckl, Jonathan R., Jonathan R. Seckl, Christopher R.W. Edwards, Stewart Fleming, Kotelevtsev, Yuri, John J. Mullins, Kotelevtsev, Y, Kenyon, C, Seckl, J R, Mullins, John J., Edwards, C R W, Fleming, S, Christopher Kenyon, Kenyon, Christopher, Brown, R W, Yuri Kotelevtsev, Roger W. Brown   +18 more
core   +1 more source