Results 41 to 50 of about 2,652,994 (308)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Radiographic manifestations of abnormal bone and mineral metabolism in end‐stage renal disease

Clinical Case Reports, 2019
Key Clinical Message Chronic kidney disease‐mineral and bone disorder (CKD‐MBD) refers to a broader clinical syndrome that develops as a systemic disorder due to CKD, manifested by abnormalities in bone and mineral metabolism and/or extraskeletal ...
Abhilash Koratala, Joan Morales Lappot, Amir Kazory   +2 more
doaj   +1 more source

Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration

Nature Communications, 2022
After acute injury, kidneys either successfully repair/regenerate or become fibrotic. Here the authors use scRNA-seq to study adaptive/maladaptive kidney regeneration and identify proinflammatory/fibrotic proximal tubule cells with pharmacologically ...
Michael S. Balzer, Tomohito Doke, Ya-Wen Yang, Daniel L. Aldridge, Hailong Hu, Hung Mai, Dhanunjay Mukhi, Ziyuan Ma, Rojesh Shrestha, Matthew B. Palmer, Christopher A. Hunter, Katalin Susztak   +11 more
doaj   +1 more source

INTERLEUKIN 17A REGULATES RENAL SODIUM TRANSPORTERS AND RENAL INJURY IN ANGIOTENSIN II-INDUCED HYPERTENSION

HYPERTENSION, 2016
Angiotensin II–induced hypertension is associated with an increase in T-cell production of interleukin-17A (IL-17A). Recently, we reported that IL-17A−/− mice exhibit blunted hypertension, preserved natriuresis in response to a saline challenge, and ...
A. Norlander, Mohamed A. Saleh, N. Kamat, B. Ko, J. Gnecco, Linjue Zhu, B. Dale, Y. Iwakura, R. Hoover, A. McDonough, Meena S. Madhur   +10 more
semanticscholar   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Acute Kidney Injury, Mild Cognitive Impairment, and Dementia: A Cohort Study of Patients from SPRINT

Kidney Medicine
Rationale & Objective: It is well accepted that acute cognitive dysfunction and delirium can occur with severe acute kidney injury (AKI). Recent evidence has indicated AKI can contribute to incident dementia years later.
Kristen L. Nowak, Anna Ostrow, Ester S. Oh, Zhiying You, Michel Chonchol   +4 more
doaj   +1 more source

Resting afferent renal nerve discharge and renal inflammation: Elucidating the role of afferent and efferent renal nerves in DOCA-salt hypertension

HYPERTENSION, 2016
Renal sympathetic denervation (RDNx) has emerged as a novel therapy for hypertension; however, the therapeutic mechanisms remain unclear. Efferent renal sympathetic nerve activity (RSNA) has recently been implicated in trafficking renal inflammatory ...
C. Banek, M. Knuepfer, Jason D Foss, Jessica K. Fiege, Ninitha Asirvatham‐Jeyaraj, D. Van Helden, Y. Shimizu, J. Osborn   +7 more
semanticscholar   +1 more source

Renal Denervation in Hypertension

Methodist DeBakey Cardiovascular Journal, 2021
The column in this issue is supplied by Drs. Benjamin Lee, MD, and Usman Ansari, DO. Dr. Lee is an assistant professor of clinical medicine at the Houston Methodist Institute for Academic Medicine and Weill Cornell Medical College. After earning his medical degree at Harvard Medical School, Dr.
Usman S, Ansari, Benjamin J, Lee
openaire   +3 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nucleotide sensors

Nature Communications
Genome-wide association studies (GWAS) have identified over 800 loci associated with kidney function, yet the specific genes, variants, and pathways involved remain elusive. By integrating kidney function GWAS with human kidney expression and methylation
Xiujie Liang, Hongbo Liu, Hailong Hu, Eunji Ha, Jianfu Zhou, Amin Abedini, Andrea Sanchez-Navarro, Konstantin A. Klötzer, Katalin Susztak   +8 more
doaj   +1 more source