Results 61 to 70 of about 2,486,822 (365)

Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay

Diabetology & Metabolic Syndrome
Objective Recently, the stress hyperglycemia ratio (SHR) has been introduced as a metric to signify relative hyperglycemia. This study aimed to investigate the relationship between SHR and in-hospital mortality and length of stay occurring during ...
Di Shen, Xintian Cai, Qing Zhu, Mulalibieke Heizhati, Junli Hu, Shuaiwei Song, Wenbo Yang, Jing Hong, Nanfang Li   +8 more
doaj   +1 more source

Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells

Stem Cell Research & Therapy, 2023
Background Obesity dysregulates key biological processes underlying the functional homeostasis, fate decisions, and reparative potential of mesenchymal stem/stromal cells (MSCs).
Logan M. Glasstetter, Tomiwa S. Oderinde, Mohit Mirchandani, Kamalnath Sankaran Rajagopalan, Samer H. Barsom, Roman Thaler, Sarosh Siddiqi, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Andre J. van Wijnen, Alfonso Eirin, Lilach O. Lerman   +13 more
doaj   +1 more source

White-Coat Hypertension Is Hypertension [PDF]

Hypertension, 2008
The article in this issue from Puato et al1 in Padova, Italy, is important because it was prospective, with 5 years of follow-up, and the hypertensive patients were never treated. They showed that carotid intima-media thickness was greater at baseline in white-coat hypertensive subjects (WCHs), increased more during follow-up than in normotensive ...
openaire   +3 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Prevalence and risk factors for hypertension and association with ethnicity in Nigeria: results from a national survey. [PDF]

, 2013
OBJECTIVE: Non-communicable diseases are now a global priority. We report on the prevalence of hypertension and its risk factors, including ethnicity, in a nationally representative sample of Nigerian adults recruited to a survey of visual impairment ...
Entekume, Gabriel, Fox, Samantha, Gilbert, Clare E, Imam, Abdullahi U, Mahdi, Abdull M, Murthy, Gudlavalleti VS, Nigeria National Blindness and Visual Impairment study group, Sivasubramaniam, Selvaraj   +7 more
core   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, Volume 15, Issue 5, Page 793-809, May 2025.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Molecular Implications of natriuretic peptides in the protection from hypertension and target organ damage development [PDF]

, 2019
The pathogenesis of hypertension, as a multifactorial trait, is complex. High blood pressure levels, in turn, concur with the development of cardiovascular damage.
Forte, Maurizio, Marchitti, Simona, Rubattu, Speranza, Volpe, Massimo   +3 more
core   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice

Diabetology & Metabolic Syndrome
Background Roux-en-Y gastric bypass (RYGB) surgery is an effective metabolic surgery against diabetes and obesity. Clinical evidence indicates that patients with severe obesity have a poor curative effect in losing weight if they suffer from leptin or ...
Dan Tong, Jie Xiang, Wei Liu, Fang Sun, Lijuan Wang, Aidi Mou, Tingbing Cao, Qing Zhou, Mei You, Yingying Liao, Peng Gao, Daoyan Liu, Zongshi Lu, Zhiming Zhu   +13 more
doaj   +1 more source

Structural and hemodynamic properties in murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension [PDF]

arXiv, 2020
Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to combine imaging data from microcomputed tomography (micro-CT) images with hemodynamic pressure and flow waveforms from
arxiv