Results 1 to 10 of about 81,072 (284)

Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice [PDF]

Frontiers in Pharmacology, 2023
Background: Febrile seizures (FSs) are the most frequent type of seizures in infancy and childhood. Epileptiform discharges (EDs) on electroencephalogram at the time of first FS recurrence can increase the risk of epilepsy development.
Hiroshi Moriyama, Sadahiro Nomura, Sadahiro Nomura, Hirochika Imoto, Hirochika Imoto, Fumiaki Oka, Yuichi Maruta, Naomasa Mori, Natsumi Fujii, Michiyasu Suzuki, Hideyuki Ishihara   +10 more
doaj   +2 more sources

Simulation and In Vitro Experimental Studies on Targeted Photothermal Therapy of Cancer using Folate-PEG-Gold Nanorods [PDF]

Journal of Biomedical Physics and Engineering, 2021
Background: Selective targeting of malignant cells is the ultimate goal of anticancer studies around the world. There are some modalities for cancer therapy devastating tumor size and growth rate, meanwhile attacking normal cells.
Shayan Maleki, Mohammad Farhadi, Seyed Kamran Kamrava, Alimohamad Asghari, Ahmad Daneshi   +4 more
doaj   +1 more source

Design and Validation of Experimental Setup for Cell Spheroid Radiofrequency-Induced Heating

Sensors, 2023
While hyperthermia has been shown to induce a variety of cytotoxic and sensitizing effects on cancer tissues, the thermal dose–effect relationship is still not well quantified, and it is still unclear how it can be optimally combined with other treatment
Ioannis Androulakis, Riccardo Ferrero, Rogier van Oossanen, Alessandra Manzin, Antonia G. Denkova, Kristina Djanashvili, Robin Nadar, Gerard C. van Rhoon   +7 more
doaj   +1 more source

Drug‐induced hyperthermia [PDF]

Anaesthesia, 1993
Summary Drugs with antidopaminergic properties and those capable of stimulating serotonin release can be responsible for hyperthermia syndromes such as neuroleptic malignant syndrome and serotonin syndrome. Dopamine and serotonin are important neurotransmitters in temperature regulation and it is likely that these reactions result ...
S M, Nimmo, B W, Kennedy, W M, Tullett, A S, Blyth, J R, Dougall   +4 more
openaire   +2 more sources

Drug-Induced Hyperthermia Review

Cureus, 2022
Humans maintain core body temperature via a complicated system of physiologic mechanisms that counteract heat/cold fluctuations from metabolism, exertion, and the environment. Overextension of these mechanisms or disruption of body temperature homeostasis leads to bodily dysfunction, culminating in a syndrome analogous to exertional heat stroke (EHS ...
Horseman, Michael, Panahi, Ladan, Udeani, George, Tenpas, Andrew S, Verduzco Jr., Rene, Patel, Pooja H, Bazan, Daniela Z, Mora, Andrea, Samuel, Nephy, Mingle, Anne-Cecile, Leon, Lisa R, Varon, Joseph, Surani, Salim   +12 more
openaire   +2 more sources

The role of mitochondria-derived reactive oxygen species in hyperthermia-induced platelet apoptosis. [PDF]

PLoS ONE, 2013
A combination of hyperthermia with radiotherapy and chemotherapy for various solid tumors has been practiced clinically. However, hyperthermic therapy has side effects, such as thrombocytopenia.
Zhicheng Wang, Feng Cai, Xiaoyu Chen, Meihong Luo, Lingling Hu, Yuan Lu   +5 more
doaj   +1 more source

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells [PDF]

, 2013
Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP).
A Jemal, A Krueger, A Krueger, A Younes, AR Safa, BR Seo, C Liu, C Odoux, CH Mom, D Atallah, D Mahalingam, DB Longley, E Raymond, FA Greco, GJ Ullenhag, HJ Zeh 3rd, HR Alexander Jr., IA Mawji, IN Lavrik, J Yoo, JA Ubersax, JM Cummins, JW Yu, L Zhang, L Zhao, LR Hafström, LY Dimberg, M Irmler, M Upreti, M Vulfovich, MA Alcala Jr., MJ Lee, P Korkolopoulou, Raffaele A Calogero, S Hegewisch-Becker, S Varghese, Seog-Young Kim, SK Libutti, T Bartke, T Ruers, T Trarbach, TR Wilson, W Gao, X Song, X Song, X Song, Xinxin Song, Y Jin-Song, Y Lin, YJ Lee, YL Zhang, Yong J. Lee, Z El Fajoui   +52 more
core   +7 more sources

Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks

iScience, 2022
Summary: Hyperthermia inhibits DNA double-strand break (DSB) repair that utilizes homologous recombination (HR) pathway by a poorly defined mechanism(s); however, the mechanisms for this inhibition remain unclear.
Sharmistha Chakraborty, Mayank Singh, Raj K. Pandita, Vipin Singh, Calvin S.C. Lo, Fransisca Leonard, Nobuo Horikoshi, Eduardo G. Moros, Deblina Guha, Clayton R. Hunt, Eric Chau, Kazi M. Ahmed, Prayas Sethi, Vijaya Charaka, Biana Godin, Kalpana Makhijani, Harry Scherthan, Jeanette Deck, Michael Hausmann, Arjamand Mushtaq, Mohammad Altaf, Kenneth S. Ramos, Krishna M. Bhat, Nitika Taneja, Chandrima Das, Tej K. Pandita   +25 more
doaj   +1 more source

MALIGNANT HYPERTHERMIA INDUCED BY CURARE [PDF]

Survey of Anesthesiology, 1974
Les auteurs rapportent deux cas d’hyperthermie maligne survenus apres administration de curare. Le premier cas survint chez un garcon de 13 ans opere pour sub-occlusion intestinale secondaire a un volvulus, et le second chez un garconnet de 8 ans opere pour appendicite aigue.
B A, Britt, G E, Webb, C, LeDuc
openaire   +2 more sources

Lipopolysaccharide potentiates hyperthermia‐induced seizures [PDF]

Brain and Behavior, 2015
AbstractBackgroundProlonged febrile seizures (FS) have both acute and long‐lasting effects on the developing brain. Because FS are often associated with peripheral infection, we aimed to develop a preclinical model of FS that simulates fever and immune activation in order to facilitate the implementation of targeted therapy after prolonged FS in young ...
Eun, Baik-Lin, Abraham, Jayne, Mlsna, Lauren, Kim, Min Jung, Koh, Sookyong   +4 more
openaire   +2 more sources