Results 11 to 20 of about 3,374,250 (258)

Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice [PDF]

Frontiers in Pharmacology, 2023
Background: Febrile seizures (FSs) are the most frequent type of seizures in infancy and childhood. Epileptiform discharges (EDs) on electroencephalogram at the time of first FS recurrence can increase the risk of epilepsy development.
Hiroshi Moriyama, Sadahiro Nomura, Sadahiro Nomura, Hirochika Imoto, Hirochika Imoto, Fumiaki Oka, Yuichi Maruta, Naomasa Mori, Natsumi Fujii, Michiyasu Suzuki, Hideyuki Ishihara   +10 more
doaj   +2 more sources

Clobazam and Valproate, but Lamotrigine, a Sodium Channel Inhibitor, Reduce the Incidence of Hyperthermia‐Induced Clonic Seizures in Dravet Syndrome Mice: Assessment of Anti‐Seizure Effects in Mice Using a Stabilized Ambient Temperature System [PDF]

Neuropsychopharmacology Reports
Background Dravet syndrome (DS) is a severe and treatment‐resistant epileptic encephalopathy, most commonly caused by de novo mutations in the sodium voltage‐gated channel alpha subunit 1 (SCN1A) gene. Patients with DS often present with febrile seizures.
Futa Sato, Mayuka Nakamura, Megumi Oishi, Yuki Matsuo, Naoki Amada, Takashi Wadatsu, Nobuyoshi Jinnai, Yusuke Kakumoto, Kenji Maeda, Yuki Yamasaki, Takashi Futamura   +10 more
doaj   +2 more sources

Simulation and In Vitro Experimental Studies on Targeted Photothermal Therapy of Cancer using Folate-PEG-Gold Nanorods [PDF]

Journal of Biomedical Physics and Engineering, 2021
Background: Selective targeting of malignant cells is the ultimate goal of anticancer studies around the world. There are some modalities for cancer therapy devastating tumor size and growth rate, meanwhile attacking normal cells.
Shayan Maleki, Mohammad Farhadi, Seyed Kamran Kamrava, Alimohamad Asghari, Ahmad Daneshi   +4 more
doaj   +1 more source

Design and Validation of Experimental Setup for Cell Spheroid Radiofrequency-Induced Heating

Sensors, 2023
While hyperthermia has been shown to induce a variety of cytotoxic and sensitizing effects on cancer tissues, the thermal dose–effect relationship is still not well quantified, and it is still unclear how it can be optimally combined with other treatment
Ioannis Androulakis, Riccardo Ferrero, Rogier van Oossanen, Alessandra Manzin, Antonia G. Denkova, Kristina Djanashvili, Robin Nadar, Gerard C. van Rhoon   +7 more
doaj   +1 more source

The role of mitochondria-derived reactive oxygen species in hyperthermia-induced platelet apoptosis. [PDF]

PLoS ONE, 2013
A combination of hyperthermia with radiotherapy and chemotherapy for various solid tumors has been practiced clinically. However, hyperthermic therapy has side effects, such as thrombocytopenia.
Zhicheng Wang, Feng Cai, Xiaoyu Chen, Meihong Luo, Lingling Hu, Yuan Lu   +5 more
doaj   +1 more source

Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks

iScience, 2022
Summary: Hyperthermia inhibits DNA double-strand break (DSB) repair that utilizes homologous recombination (HR) pathway by a poorly defined mechanism(s); however, the mechanisms for this inhibition remain unclear.
Sharmistha Chakraborty, Mayank Singh, Raj K. Pandita, Vipin Singh, Calvin S.C. Lo, Fransisca Leonard, Nobuo Horikoshi, Eduardo G. Moros, Deblina Guha, Clayton R. Hunt, Eric Chau, Kazi M. Ahmed, Prayas Sethi, Vijaya Charaka, Biana Godin, Kalpana Makhijani, Harry Scherthan, Jeanette Deck, Michael Hausmann, Arjamand Mushtaq, Mohammad Altaf, Kenneth S. Ramos, Krishna M. Bhat, Nitika Taneja, Chandrima Das, Tej K. Pandita   +25 more
doaj   +1 more source

Hyperthermia Induces Apoptosis of 786-O Cells through Suppressing Ku80 Expression. [PDF]

PLoS ONE, 2015
Hyperthermia as an anticancer method has been paid increasing attention in recent years. Several studies have shown that hyperthermia can kill tumor cells by inducing apoptosis.
Defeng Qi, Yuan Hu, Jinhui Li, Tao Peng, Jialin Su, Yun He, Weidong Ji   +6 more
doaj   +1 more source

CuS-¹³¹I-PEG Nanotheranostics-Induced “Multiple Mild-Hyperthermia” Strategy to Overcome Radio-Resistance in Lung Cancer Brachytherapy

Pharmaceutics, 2022
Brachytherapy is one mainstay treatment for lung cancer. However, a great challenge in brachytherapy is radio-resistance, which is caused by severe hypoxia in solid tumors. In this research, we have developed a PEGylated 131I-labeled CuS nanotheranostics
Yanna Cui, Hui Yan, Haoze Wang, Yongming Zhang, Meng Li, Kai Cui, Zeyu Xiao, Liu Liu, Wenhui Xie   +8 more
doaj   +1 more source

Intra-peritoneal hyperthermia combining α-galactosylceramide in the treatment of ovarian cancer. [PDF]

PLoS ONE, 2013
The purpose of this study was to investigate the anti-tumor effect and potential mechanisms of i.p. hyperthermia in combination with α-galactosylceramide (α-GalCer) for the treatment of ovarian cancer.
Chao-Chih Wu, Yin-Ting Chuang, Yun-Ting Hsu, Jung-Tang Huang, T-C Wu, Chien-Fu Hung, Yuh-Cheng Yang, Chih-Long Chang   +7 more
doaj   +1 more source

AKT inhibitor suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells

Brazilian Journal of Medical and Biological Research, 2013
Hyperthermia is one of the most effective adjuvant treatments for various cancers with few side effects. However, the underlying molecular mechanisms still are not known. N-myc downstream-regulated gene 2 (NDRG2), a tumor suppressor, has been shown to be
Yurong Tao, Yan Guo, Wenchao Liu, Jian Zhang, Xia Li, Lan Shen, Yi Ru, Yan Xue, Jin Zheng, Xinping Liu, Jing Zhang, Libo Yao   +11 more
doaj   +3 more sources