Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model. [PDF]
Front Pharmacol, 2021 Treatment options for Dravet syndrome are limited. The aim of this study was to evaluate the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome (Scn1a E1099X/+ ). We report here that the PER (2 mg/kg)
Ho SY +5 more
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Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models. [PDF]
Int J Mol Sci, 2020 The benefits of high-fever range hyperthermia have been utilized in medicine from the Ancient Greek culture to the present day. Amplitude-modulated electro-hyperthermia, induced by a 13.56 MHz radiofrequency current (mEHT, or Oncothermia), has been an ...
Krenacs T +6 more
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Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice [PDF]
Frontiers in Pharmacology, 2023 Background: Febrile seizures (FSs) are the most frequent type of seizures in infancy and childhood. Epileptiform discharges (EDs) on electroencephalogram at the time of first FS recurrence can increase the risk of epilepsy development.
Hiroshi Moriyama +10 more
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On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation. [PDF]
Cancers (Basel), 2019 The DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counteract ...
van den Tempel N +8 more
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Lipopolysaccharide potentiates hyperthermia‐induced seizures [PDF]
Brain and Behavior, 2015 AbstractBackgroundProlonged febrile seizures (FS) have both acute and long‐lasting effects on the developing brain. Because FS are often associated with peripheral infection, we aimed to develop a preclinical model of FS that simulates fever and immune activation in order to facilitate the implementation of targeted therapy after prolonged FS in young ...
Eun, Baik-Lin +4 more
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Biodegradable nanotheranostics with hyperthermia-induced bubble ability for ultrasound imaging-guided chemo-photothermal therapy. [PDF]
Int J Nanomedicine, 2019 Background Theranostics, elaborately integrating both therapeutic and diagnostic functions into a nanoplatform holds great potential for precision cancer medicine.
Xu C +7 more
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Characteristics of hyperthermia-induced hyperventilation in humans [PDF]
Temperature, 2016 In humans, hyperthermia leads to activation of a set of thermoregulatory responses that includes cutaneous vasodilation and sweating. Hyperthermia also increases ventilation in humans, as is observed in panting dogs, but the physiological significance and characteristics of the hyperventilatory response in humans remain unclear.
Tsuji, Bun +3 more
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Simulation and In Vitro Experimental Studies on Targeted Photothermal Therapy of Cancer using Folate-PEG-Gold Nanorods [PDF]
Journal of Biomedical Physics and Engineering, 2021 Background: Selective targeting of malignant cells is the ultimate goal of anticancer studies around the world. There are some modalities for cancer therapy devastating tumor size and growth rate, meanwhile attacking normal cells.
Shayan Maleki +4 more
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Design and Validation of Experimental Setup for Cell Spheroid Radiofrequency-Induced Heating
Sensors, 2023 While hyperthermia has been shown to induce a variety of cytotoxic and sensitizing effects on cancer tissues, the thermal dose–effect relationship is still not well quantified, and it is still unclear how it can be optimally combined with other treatment
Ioannis Androulakis +7 more
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Drug‐induced hyperthermia [PDF]
Anaesthesia, 1993 Summary Drugs with antidopaminergic properties and those capable of stimulating serotonin release can be responsible for hyperthermia syndromes such as neuroleptic malignant syndrome and serotonin syndrome. Dopamine and serotonin are important neurotransmitters in temperature regulation and it is likely that these reactions result ...
S M, Nimmo +4 more
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