Results 221 to 230 of about 81,072 (284)
Anaesthesia, EarlyView.Summary Introduction The UK NHS is committed to reaching net zero carbon emissions by 2040. Volatile anaesthetic agents are potent greenhouse gases and alternative intravenous methods exist. We aimed to predict the cost‐effectiveness of a transition from volatile anaesthesia to total intravenous anaesthesia to reduce carbon emissions. Methods A general
Daniel Leslie, Christopher J. Mullington
wiley +1 more source
Safety pharmacology of acute mescaline administration in healthy participants
British Journal of Clinical Pharmacology, EarlyView.Aims Psychedelics, including mescaline, may serve as novel treatments for depression and anxiety. However, data is scarce on the safety of mescaline. Methods The present pooled analysis included two double‐blind, randomized, placebo‐controlled studies with a total of 48 participants and 96 mescaline administrations. Single oral‐dose administrations (n =
Aaron Klaiber +4 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Samantha L. Reed +8 more
wiley +1 more source
On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation. [PDF]
Cancers (Basel), 2019 van den Tempel N +8 more
europepmc +1 more source
Equine Veterinary Journal, EarlyView.Abstract The need for comprehensive equine welfare assessments has become particularly evident amid ongoing debates about the social licence to operate in equestrian sports. During exercise, multiple physiological systems, principally the cardiovascular, respiratory, muscular, thermoregulatory, endocrine, and locomotory systems, undergo complex ...
Rhana Mackie Aarts +3 more
wiley +1 more source
TRPM3 activation causes CGRP release in trigeminal neurons: Implications for migraine mechanisms
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Background The transient receptor potential melastatin 3 (TRPM3) ion channel has been implicated in sensory modulation and pain transmission and may contribute to migraine pathophysiology through calcitonin gene‐related peptide (CGRP) release in the trigeminovascular system. This study aimed to investigate TRPM3 activation and its role in CGRP
Philip V. Reducha +9 more
wiley +1 more source
Ibis, EarlyView.The identification of key habitats of threatened species and of extrinsic environmental factors that influence their resilience to human‐induced environmental changes are the foundation for the definition of conservation objectives. Using the presence and numerical abundance data collected in a long‐term survey (2000–24) of breeding colonies of Lesser ...
Maurizio Sarà, Rosario Mascara
wiley +1 more source
Size of Subcortical Band Heterotopia Influences the Susceptibility to Hyperthermia-Induced Seizures in a Rat Model. [PDF]
Front Cell Neurosci, 2019 Moustaki K +5 more
europepmc +1 more source
Journal of Fish Diseases, Volume 48, Issue 4, April 2025.ABSTRACT The pejerrey (Odontesthes bonariensis) is a key species for recreational and commercial fisheries in Argentina and holds significant aquaculture potential. It has been introduced to various countries worldwide, including Japan, where intensive aquaculture has developed.
Aarón Torres‐Martínez +4 more
wiley +1 more source