Results 221 to 230 of about 3,374,250 (258)

Safety pharmacology of acute mescaline administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Psychedelics, including mescaline, may serve as novel treatments for depression and anxiety. However, data is scarce on the safety of mescaline. Methods The present pooled analysis included two double‐blind, randomized, placebo‐controlled studies with a total of 48 participants and 96 mescaline administrations. Single oral‐dose administrations (n =
Aaron Klaiber, Mélusine Humbert‐Droz, Laura Ley, Yasmin Schmid, Matthias E. Liechti   +4 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation. [PDF]

Cancers (Basel), 2019
van den Tempel N, Zelensky AN, Odijk H, Laffeber C, Schmidt CK, Brandsma I, Demmers J, Krawczyk PM, Kanaar R.   +8 more
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, EarlyView.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source

Streptococcus equi subsp. equi infection causing temporomandibular septic arthritis treated by mandibular condylectomy in a horse

Equine Veterinary Education, EarlyView.
Summary A 26‐year‐old pony mare was referred for weight loss, dysphagia, lethargy and fever. Clinical examination revealed left temporal swelling, masseter muscle atrophy and malocclusion. Computed tomography examination showed severe temporomandibular joint (TMJ) alteration, extensive osteolysis of the mandibular condyle and temporal bone and ...
L. Gross, A. Charbonnel, A. Meurice, C. De Fourmestraux   +3 more
wiley   +1 more source

Size of Subcortical Band Heterotopia Influences the Susceptibility to Hyperthermia-Induced Seizures in a Rat Model. [PDF]

Front Cell Neurosci, 2019
Moustaki K, Buhler E, Martinez R, Watrin F, Represa A, Manent JB.   +5 more
europepmc   +1 more source

Unraveling Biotypes Related to Thermotolerance During Lactation in Maternal‐Line Pigs Through Principal Component and Factor Analyses

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Heat stress imposes significant challenges to welfare, health, and productivity of lactating sows due to their limited thermoregulatory capacity and increased metabolic heat load. Genetic selection for improved heat tolerance is a promising yet complex approach, given the large number of biological processes involved in heat stress response ...
Cassiane Gomes dos Santos, Renata Veroneze, Artur O. Rocha, Hinayah Rojas de Oliveira, Letícia Fernanda de Oliveira, Jay S. Johnson, Pedro H. F. Freitas, Hui Wen, Allan P. Schinckel, Luiz F. Brito   +9 more
wiley   +1 more source

Pejerrey (Odontesthes bonariensis) Under Siege: Main Infectious Diseases and Their Role in Aquaculture and Wild Populations Amidst Environmental Change

Journal of Fish Diseases, Volume 48, Issue 4, April 2025.
ABSTRACT The pejerrey (Odontesthes bonariensis) is a key species for recreational and commercial fisheries in Argentina and holds significant aquaculture potential. It has been introduced to various countries worldwide, including Japan, where intensive aquaculture has developed.
Aarón Torres‐Martínez, Miguel Mancini, Fabian Grosman, Gustavo Manuel Somoza, Carlos Augusto Strüssmann   +4 more
wiley   +1 more source

Phototherapies mediated by metallic nanoparticles and near‐infrared radiation in skin cancer: A systematic review

Photochemistry and Photobiology, EarlyView.
Recent studies demonstrate that near‐infrared (NIR—750–980 nm)‐mediated photodynamic (PDT) and photothermal (PTT) therapies, combined with metallic nanoparticles (MNPs), show promising results against skin cancer, particularly melanoma, in both in vitro and in vivo models.
Tamyris Devincenzi, Alessandra Costa Lopes, Marcelo Augusto Germani Marinho, Daza de Moraes Vaz Batista Filgueira   +3 more
wiley   +1 more source