Results 71 to 80 of about 13,758 (226)

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Tonic-Clonic Seizure following Cytoreductive Surgery with Intraperitoneal Oxaliplatin: A Case Report and Review of the Literature

Case Reports in Oncology, 2016
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal (IP) chemotherapy (HIPEC) is believed to improve outcomes in well-selected patients with peritoneal carcinomatosis.
Jessica Sayuri Tsukamoto, Marcos Belotto de Oliveira, Renata D'Alpino Peixoto   +2 more
doaj   +1 more source

Study on the thermal stability of nab-paclitaxel during hyperthermic intraperitoneal chemotherapy

BMC Pharmacology and Toxicology, 2023
Background Albumin-bound paclitaxel (nab-paclitaxel), as a special targeted preparation of paclitaxel, has the advantages of good curative effect and less side effects in anti-tumor therapy. The existence of the plasma-peritoneal barrier and insufficient
Jingjing Zhang, Luya Li, Jintuo Yin, Xidong Zhang, Ying Zheng, Rui Feng   +5 more
doaj   +1 more source

Multimodal treatment of gastric cancer in the west: Where are we going? [PDF]

, 2015
The incidence of gastric cancer (GC) is decreasing worldwide, especially for intestinal histotype of the distal third of the stomach. On the contrary, proximal location and diffuse Lauren histotype have been reported to be generally stable over time.
Baiocchi, Gl, de Manzoni, G, Marrelli, D, Morgagni, P, Polom, K, Roviello, F   +5 more
core   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Peritoneaalse kartsinomatoosi kombineeritud ravi tsütoreduktiivse operatsiooni ja intraperitoneaalse keemiaraviga [PDF]

, 2009
Levik kõhukelmele on seedetrakti ja günekoloogiliste kaugelearenenud kasvajate või nende taaspuhkemise üks sagedasi ilminguid. Peritoneaalse kartsinomatoosi tervistava ravi võimalused on olnud üsna piiratud ja prognoos seetõttu halb.
Arak, Andrus
core   +2 more sources

A Case Illustrating Challenges: Early‐Onset Signet Ring Cell Rectal Carcinoma With Fulminant Peritoneal Progression

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Signet ring cell carcinoma (SRCC) of the rectum is a rare histologic subtype and is often associated with aggressive behavior and poor outcomes, particularly in young patients. We report a 19‐year‐old male who presented with acute intestinal obstruction and was diagnosed with rectal SRCC, radiologically staged as cT2N1bM0, acknowledging the ...
Shivraj Sharma, Madhav Raj Karki, Aron Neupane, Shristi Gupta, Dikshya Pokhrel, Kshitiz Parajuli, Nikhil Agarwal   +6 more
wiley   +1 more source

Tumour‐targeted fluorescence‐guided surgery in gastrointestinal cancer: A systematic review of preclinical and clinical research

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Tumour‐targeted fluorescence‐guided surgery (Ttfgs) enhances intraoperative precision in gastrointestinal cancer treatment. Translation of (Ttfgs) into clinical practice is limited by heterogeneity, regulatory hurdles, biomarker variability and absence of phase III trials.
Aaya Darai, Evie H. M. Graus, Femke J. A. van der Stroom, Mark Rijpkema, Alexander Vahrmeijer, Denise E. Hilling, Johannes H. W. De Wilt, Merlijn Hutteman   +7 more
wiley   +1 more source

Cytoreductive Surgery and Hyperthermic İntraperitoneal Chemoterapy for Advance Gastric Cancer Associated Peritoneal Carcinomatosis Single Centre Unit for 10 Consecutive Patients

Haseki Tıp Bülteni, 2019
Aim:Hyperthermic intraperitoneal chemotherapy with cytoreductive surgery has a positive effect on survival in advanced abdominal cancers. We aimed to present our experience with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in ...
Özgül Düzgün, Sema Yüksekdağ, Murat Kalın, Şenol Çomoğlu, Semra Yanık, Ömer Faruk Özkan, Neşet Köksal   +6 more
doaj   +1 more source

Assessing the Accuracy of Large Language Models on European Guidelines for Cervical Cancer: An In Silico Benchmarking Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 4, Page 771-778, March 2026.
ABSTRACT Objective Although large language models are increasingly used in clinical and research settings, the validity of the information they provide remains uncertain. This study aimed to evaluate the accuracy, consistency, and reliability of three large language models—ChatGPT 4.0, DeepSeek R1, and Gemini 2.0—in answering cervical cancer‐related ...
Matteo Pavone, Chiara Innocenzi, Nicola Macellari, Chiara Cantarini, Massimo Criscione, Andrea Rosati, Lise Lecointre, Antonella Carcagnì, Barbara Costantini, Jacques Marescaux, Anna Fagotti, Francesco Fanfani, David Cibula, Denis Querleu, Nicolò Bizzarri   +14 more
wiley   +1 more source