Results 61 to 70 of about 446,414 (163)
Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer
MedComm, Volume 7, Issue 9, September 2026.This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu +9 morewiley +1 more sourceA Prognostic Stratification Model for Ovarian Cancer Integrating the Tumor‐Associated Macrophages/Programmed Death‐Ligand 1 Axis
Organ Medicine, Volume 3, Issue 3, Page 148-156, September 2026.Tumor‐associated macrophages (TAMs) drive ovarian cancer (OC) progression and immune escape mainly via programmed death‐ligand 1 (PD‐L1) upregulation. This study aimed to construct a risk stratification model integrating these two immune biomarkers for OC precision prognosis.Li Liu, Chenya Zhuo, Tingting Zhao, Qiongshan Liu, Yun Liu, Jingran Du, Dandan Yan, Qiuxiao Tan, Hui Fei, Xiaohui Tian, Mengxiong Li +10 morewiley +1 more sourceKnowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours
The Journal of Pathology, Volume 270, Issue 1, Page 4-22, September 2026.Abstract
Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.Iris D Nagtegaal, Elizabeth A Montgomery, Alexandros D Polydorides, Anthony J Gill, Motohiro Kojima, Mark J Arends +5 morewiley +1 more sourceDetection and treatment of peritoneal metastases in colon cancer: COLOPEC trial compared to routine practice
Colorectal Disease, Volume 28, Issue 9, September 2026.Abstract Aim
The randomized COLOPEC trial demonstrated no benefit of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in preventing peritoneal metastases in locally advanced colon cancer. Because all patients underwent a diagnostic laparoscopy at 18 months, the study lacked a true control arm, leaving the effect of early detection and ...Iris Hochstenbach, Julie J. M. Hamm, Eva Rademaker, Arend G. J. Aalbers, Djamila Boerma, Wilhelmina M. U. van Grevenstein, Patrick H. J. Hemmer, Ignace H. J. T. De Hingh, Niels F. M. Kok, Jurriaan B. Tuynman, Eva V. E. Madsen, Johannes H. W. de Wilt, Esther C. J. Consten, Henderik L. van Westreenen, Pieter J. Tanis, on behalf of the COLOPEC Collaborators Group, Dutch Snapshot Research Group and Dutch Complex Colon Cancer Initiative, Caroline S. Andeweg, Vivian P. Bastiaenen, Willem A. Bemelman, Jarmila D.W. van der Bilt, Johanne Bloemen, Frank C. den Boer, Daan ten Bokkel Huinink, Cancer Clinic, Alexandra R.M. Brandt‐Kerkhof, Andre J.A. Bremers, Walter J.A. Brokelman, Huib A. Cense, Geert‐Jan Creemers, Johannes Crezee, Rogier M.P.H. Crolla, Jan‐Willem T. Dekker, Jennifer Demelinne, Marc J. van Det, Ziekehuisgroep Twente, Karin K. van Diepen, Marjolein Diepeveen, Gastrointestinal Surgery, Marcel G.W. Dijkgraaf, Eino B. van Duyn, Medisch Spectrum Twente, Esther D. van den Ende, Ziekehuisgroep Twente, Pauline Evers, Hans F.J. Fabry, Floris T.J. Ferenschild, Maashospital Pantein, Sebastiaan Festen, Onze Lieve Vrouwen Gasthuis, Anna A.W. van Geloven, Erwin van der Harst, Jeroen Heemskerk, Joost T. Heikens, Daniel A. Hess, Bas Inberg, Streekziekenhuis Koningin Beatrix, Jan Jansen, Charlotte E.L. Klaver, Frank W.H. Kloppenberg, Treant Zorggroep, Thomas J.M. Kootstra, R. T. J. Kortekaas, Maartje Los, H. C. J. van der Mijle, Linda Mol, Gijsbert D. Musters, Peter A. Neijenhuis, Simon W. Nienhuijs, Loes van den Nieuwenhof, Koen C.M.J. Peeters, Sebastiaan W. Polle, Jolien Pon, Pieter Poortman, Cornelis J.A. Punt, Sandra A. Radema, Bert van Ramshorst, Philip R. de Reuver, Koen P. Rovers, Roderick F. Schmitz, Lotte Schoonderwoerd, Nina Sluiter, Dirkje W. Sommeijer, Eric Sonneveld, T. C. van Sprundel, Sanne C. Veltkamp, Maarten Vermaas, Victor J. Verwaal, Emma Wassenaar, Johannes A. Wegdam, Marinke Westerterp, Marinus J. Wiezer, Daniel D. Wisselink, Fennie Wit, Arjen J. Witkamp, Karlijn van Woensdregt, Edwin S. van der Zaag, David D.E. Zimmerman, Mandy Zournas, Annette van Zweeden, D. C. Van der Aa, S. M. Van Aalten, I. Aanen, F. J. Amelung, Den Bosch, P. Van Amstel, E. Ancion, J. J. Atema, T. S. Aukema, V. Baart, E. Z. Barsom, V. P. Bastiaenen, T. Bazuin, M. A. J. Becker, V. M. Belvroy, R. H. A. Berndsen, B. Biersteker, J. D. W. Van der Bilt, J. G. Bloemen, S. Bluiminck, F. C. Den Boer, E. G. Boerma, M. C. Boonstra, W. A. A. Borstlap, L. A. Brugts, J. W. A. Burger, T. A. Burghgraef, S. M. M. De Castro, M. Cleveringa, R. J. S. Coelen, A. Demirkiran, E. Dijkema, S. Dijkink, S. A. Dingemans, L. Van Dullemen, E. B. Van Duyn, A. J. Eleveld, H. A. Galema, E. G. M. Van Geffen, R. T. J. Geitenbeek, A. A. W. Van Geloven, A. H. C. Gielen, C. A. Gispen, M. J. P. M. Govaert, V. P. Groot, B. A. Grotenhuis, A. A. J. Grüter, S. F. Hardon, A. G. Den Hartog, K. Havenga, J. A. G. Van der Heijden, F. Heilijgers, T. B. M. Van den Heuvel, R. S. Hijmans, J. Van Hilst, J. C. Hol, S. Janki, A. C. H. M. Jongen, I. Kappers, S. Karhof, B. A. J. Kertzman, M. M. Kieboom, N. Koemans, J. L. M. Konsten, W. H. Kopp, O. W. Kranenburg, P. Krielen, A. Kumas, M. Kusters, D. P. V. Lambrichts, B. Lamme, G. L. Van Leeuwen, E. W. Lockhorst, H. Lutfi, S. Malm, H. T. J. Mantel, G. A. Martini, P. Meijer, J. Melenhorst, D. M. Mens, MC Erasmus, M. J. H. Metman, L. C. F. De Nes, L. R. Moolenaar, J. A. Nieuwstraten, J. Nonner, S. E. Van Oostendorp, S. J. Oosterling, C. M. W. Pesch, C. M. L. Peters, M. W. H. Philipsen, W. Y. Van der Plas, M. M. Poelman, F. Polat, A. E. Posma‐Bouman, B. B. Pultrum, J. M. Van Rees, W. P. Reinders, P. R. De Reuver, M. C. Richir, T. W. H. Rijnhout, M. M. Romeijn, D. Roorda, C. C. Van Rossem, J. Rothbarth, M. Ruig, H. G. Sahin, I. Said, R. A. Schasfoort, J. Scholten, P. M. E. Schuivens, D. Schweitzer, C. Sietses, M. Sietzema, G. D. Slooter, N. Smakman, B. P. Smalbroek, E. J. Spillenaar Bilgen, E. J. A. Steller, T. F. Stoop, M. Straver, S. K. Stuart, A. Suntharan, A. K. Talsma, K. Trumpi, J. Veenhuizen, A. W. H. Van de Ven, E. G. G. Verdaasdonk, P. M. Verheijen, A. Villerius‐Meijer, M. Vissers, E. L. K. Voogt, R. P. H. De Vries, S. T. Van Vugt, D. D. De Waard, T. R. Wagner, A. K. Warps, R. H. A. Welling, M. Westerterp, J. K. Wiggers, A. R. Wijsmuller, C. D. M. Witjes, B. Zamaray, N. Van Zenden, S. J. M. Zomer, E. S. Zwanenburg, E. S. Zwart, S. L. M. Zwetsloot, M. J. Lahaye, P. D. Siersema, P. Snaebjornsson +250 morewiley +1 more sourceRetrospective Study of the Epidemiology, Pathology, and Therapeutic Management in Patients With Mucinous Ovarian Tumors
Technology in Cancer Research & Treatment, 2020 Aim: We sought to determine the epidemiology of mucinous ovarian tumors, the correlation between serum biomarkers and tumor status, and the outcomes of the management in different subtypes of mucinous ovarian tumors in a Chinese surgical cohort. Methods: Yuanyuan Zhang PhD, Chunmei Li MD, Suiyu Luo MD, Ying Su MD, Xiaoqing Gang MD, Peiyuan Chu MD, JuXin Zhang MD, Henghui Wu MD, Guangzhi Liu PhD +8 moredoaj +1 more source