Results 71 to 80 of about 490,601 (215)
Spatiotemporal immune heterogeneity and precision immunotherapy for ovarian cancer
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Graphical Highlights
Spatiotemporal immune heterogeneity shapes distinct and evolving immune ecosystems in ovarian cancer.
Multimodal biomarkers enable biologically informed patient stratification beyond static single‐marker approaches.
Precision immunotherapy should match dominant immune barriers across lesions and treatment stages.Xinfeng Yang, Yida Wang, Haiyue You, Jingyi Gao, Yangkun Feng, Feng Zhang, Yan Zhang, Bing Zhang, Shaojie Zhao, Yanfang Gu +9 morewiley +1 more sourceHyperthermic intraperitoneal chemotherapy is an independent risk factor for development of acute kidney injury
, 2020 Purpose: Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) or hyperthermic intrapleural chemotherapy (HIC) has been established as the new treatment modality for selected patients with peritoneal and pleural ...Dagel, Tuncay, Vatansever, Dogan, Dilege, Sukru, Yalti, Tunc, AFŞAR, Barış, Misirlioglu, Selim, Bugra, Dursun, Erus, Suat, Kanbay, Mehmet, Tanju, Serhan, Selcukbiriciks, Fatih, Mandel, Nil Molinas, Bank, Emre, Taskiran, Cagatay +13 morecore Detection and treatment of peritoneal metastases in colon cancer: COLOPEC trial compared to routine practice
Colorectal Disease, Volume 28, Issue 9, September 2026.Abstract Aim
The randomized COLOPEC trial demonstrated no benefit of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in preventing peritoneal metastases in locally advanced colon cancer. Because all patients underwent a diagnostic laparoscopy at 18 months, the study lacked a true control arm, leaving the effect of early detection and ...Iris Hochstenbach, Julie J. M. Hamm, Eva Rademaker, Arend G. J. Aalbers, Djamila Boerma, Wilhelmina M. U. van Grevenstein, Patrick H. J. Hemmer, Ignace H. J. T. De Hingh, Niels F. M. Kok, Jurriaan B. Tuynman, Eva V. E. Madsen, Johannes H. W. de Wilt, Esther C. J. Consten, Henderik L. van Westreenen, Pieter J. Tanis, on behalf of the COLOPEC Collaborators Group, Dutch Snapshot Research Group and Dutch Complex Colon Cancer Initiative, Caroline S. Andeweg, Vivian P. Bastiaenen, Willem A. Bemelman, Jarmila D.W. van der Bilt, Johanne Bloemen, Frank C. den Boer, Daan ten Bokkel Huinink, Cancer Clinic, Alexandra R.M. Brandt‐Kerkhof, Andre J.A. Bremers, Walter J.A. Brokelman, Huib A. Cense, Geert‐Jan Creemers, Johannes Crezee, Rogier M.P.H. Crolla, Jan‐Willem T. Dekker, Jennifer Demelinne, Marc J. van Det, Ziekehuisgroep Twente, Karin K. van Diepen, Marjolein Diepeveen, Gastrointestinal Surgery, Marcel G.W. Dijkgraaf, Eino B. van Duyn, Medisch Spectrum Twente, Esther D. van den Ende, Ziekehuisgroep Twente, Pauline Evers, Hans F.J. Fabry, Floris T.J. Ferenschild, Maashospital Pantein, Sebastiaan Festen, Onze Lieve Vrouwen Gasthuis, Anna A.W. van Geloven, Erwin van der Harst, Jeroen Heemskerk, Joost T. Heikens, Daniel A. Hess, Bas Inberg, Streekziekenhuis Koningin Beatrix, Jan Jansen, Charlotte E.L. Klaver, Frank W.H. Kloppenberg, Treant Zorggroep, Thomas J.M. Kootstra, R. T. J. Kortekaas, Maartje Los, H. C. J. van der Mijle, Linda Mol, Gijsbert D. Musters, Peter A. Neijenhuis, Simon W. Nienhuijs, Loes van den Nieuwenhof, Koen C.M.J. Peeters, Sebastiaan W. Polle, Jolien Pon, Pieter Poortman, Cornelis J.A. Punt, Sandra A. Radema, Bert van Ramshorst, Philip R. de Reuver, Koen P. Rovers, Roderick F. Schmitz, Lotte Schoonderwoerd, Nina Sluiter, Dirkje W. Sommeijer, Eric Sonneveld, T. C. van Sprundel, Sanne C. Veltkamp, Maarten Vermaas, Victor J. Verwaal, Emma Wassenaar, Johannes A. Wegdam, Marinke Westerterp, Marinus J. Wiezer, Daniel D. Wisselink, Fennie Wit, Arjen J. Witkamp, Karlijn van Woensdregt, Edwin S. van der Zaag, David D.E. Zimmerman, Mandy Zournas, Annette van Zweeden, D. C. Van der Aa, S. M. Van Aalten, I. Aanen, F. J. Amelung, Den Bosch, P. Van Amstel, E. Ancion, J. J. Atema, T. S. Aukema, V. Baart, E. Z. Barsom, V. P. Bastiaenen, T. Bazuin, M. A. J. Becker, V. M. Belvroy, R. H. A. Berndsen, B. Biersteker, J. D. W. Van der Bilt, J. G. Bloemen, S. Bluiminck, F. C. Den Boer, E. G. Boerma, M. C. Boonstra, W. A. A. Borstlap, L. A. Brugts, J. W. A. Burger, T. A. Burghgraef, S. M. M. De Castro, M. Cleveringa, R. J. S. Coelen, A. Demirkiran, E. Dijkema, S. Dijkink, S. A. Dingemans, L. Van Dullemen, E. B. Van Duyn, A. J. Eleveld, H. A. Galema, E. G. M. Van Geffen, R. T. J. Geitenbeek, A. A. W. Van Geloven, A. H. C. Gielen, C. A. Gispen, M. J. P. M. Govaert, V. P. Groot, B. A. Grotenhuis, A. A. J. Grüter, S. F. Hardon, A. G. Den Hartog, K. Havenga, J. A. G. Van der Heijden, F. Heilijgers, T. B. M. Van den Heuvel, R. S. Hijmans, J. Van Hilst, J. C. Hol, S. Janki, A. C. H. M. Jongen, I. Kappers, S. Karhof, B. A. J. Kertzman, M. M. Kieboom, N. Koemans, J. L. M. Konsten, W. H. Kopp, O. W. Kranenburg, P. Krielen, A. Kumas, M. Kusters, D. P. V. Lambrichts, B. Lamme, G. L. Van Leeuwen, E. W. Lockhorst, H. Lutfi, S. Malm, H. T. J. Mantel, G. A. Martini, P. Meijer, J. Melenhorst, D. M. Mens, MC Erasmus, M. J. H. Metman, L. C. F. De Nes, L. R. Moolenaar, J. A. Nieuwstraten, J. Nonner, S. E. Van Oostendorp, S. J. Oosterling, C. M. W. Pesch, C. M. L. Peters, M. W. H. Philipsen, W. Y. Van der Plas, M. M. Poelman, F. Polat, A. E. Posma‐Bouman, B. B. Pultrum, J. M. Van Rees, W. P. Reinders, P. R. De Reuver, M. C. Richir, T. W. H. Rijnhout, M. M. Romeijn, D. Roorda, C. C. Van Rossem, J. Rothbarth, M. Ruig, H. G. Sahin, I. Said, R. A. Schasfoort, J. Scholten, P. M. E. Schuivens, D. Schweitzer, C. Sietses, M. Sietzema, G. D. Slooter, N. Smakman, B. P. Smalbroek, E. J. Spillenaar Bilgen, E. J. A. Steller, T. F. Stoop, M. Straver, S. K. Stuart, A. Suntharan, A. K. Talsma, K. Trumpi, J. Veenhuizen, A. W. H. Van de Ven, E. G. G. Verdaasdonk, P. M. Verheijen, A. Villerius‐Meijer, M. Vissers, E. L. K. Voogt, R. P. H. De Vries, S. T. Van Vugt, D. D. De Waard, T. R. Wagner, A. K. Warps, R. H. A. Welling, M. Westerterp, J. K. Wiggers, A. R. Wijsmuller, C. D. M. Witjes, B. Zamaray, N. Van Zenden, S. J. M. Zomer, E. S. Zwanenburg, E. S. Zwart, S. L. M. Zwetsloot, M. J. Lahaye, P. D. Siersema, P. Snaebjornsson +250 morewiley +1 more sourceRoutine prophylactic ureteral stenting before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Safety and usefulness from a single-center experience
, 2019 There are very few evidences about safety and usefulness of routine prophylactic ureteral stenting (PUS) before cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)Fugazzola P., Ansaloni L., Sibilla M. G., Lippi A., Cicuttin E., Tomasoni M., Pisano M., Coccolini F., Improta M., Gubbiotti F., Montori G., Ceresoli M., Enrico Cicuttin, Matteo Tomasoni, Giulia Montori, Paola Fugazzola, Federico Coccolini, Michele Pisano, Mario Improta, Luca Ansaloni, Andrea Lippi, Marco Ceresoli, Francesca Gubbiotti, Maria Grazia Sibilla +23 morecore +1 more sourceTherapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles
Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are Gloria Kemunto, Kristen Dellingerwiley +1 more sourceAn Open Source Automated Tumor Infiltrating Lymphocytes Algorithm for Prognosis in Primary Small Bowel Adenocarcinoma Using Routine Hematoxylin and Eosin Stained Sections
Cancer Medicine, Volume 15, Issue 8, August 2026.ABSTRACT Objective
While tumor‐infiltrating lymphocytes (TILs) are prognostic in various cancers, their role in small bowel adenocarcinoma (SBA) is unexplored. This study evaluates the prognostic significance of digitally quantified TILs in SBA. Methods
Using digital pathology (QuPath) on hematoxylin and eosin (H&E)‐stained slides from 62 SBA cases, we Minying Deng, Xin Liu, Yuanlong Luo, Ayizimugu Abuduwaili, Qi Song, Rongkui Luo, Wen Huang, Lei Xu, Xiaolei Zhang, Lin Sun, Jieakesu Su, Chen Xu, Yingyong Hou +12 morewiley +1 more source
