Results 81 to 90 of about 41,010 (268)

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Efficiency of hypertonic and isotonic seawater solutions in chronic rhinosinusitis

Medicinski Glasnik, 2010
Aim To compare the efficiency of isotonic and hypertonic seawatersolutions used for nasal lavage and quality of life of the patientswith chronic rhinosinusitis. Methods A random and controlled clinical study was performed.
Josip Čulig, Marcel Leppée, Andrijana Včeva, Davorin Djanic   +3 more
doaj  

Evaluating the Effect of Adding Furosemide to Hypertonic Saline 5% on the Intracranial Pressure in Candidates of Craniotomy for Resection of Supratentorial Brain Tumors

مجله دانشکده پزشکی اصفهان, 2018
Background: Increasing in intracranial pressure is a life-threatening condition during craniotomy surgery, which increases the incidence of complications and mortality in patients. Therefore, it is necessary to find a way to cure this complication.
Mehrdad Masoudifar, Shirin Shams-khoramabadi   +1 more
doaj   +1 more source

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze, Robyn Whitney, Dorothée Ville, Nathalie Villeneuve, Anna‐Maria Hartmann, Lisa Becker, Jens Hausmann, Jinwei Zhang, Cathy Brier, Lucie I. Pisella, Perrine Friedel, Audrey Labalme, Eudeline Alix, Nicolas Chatron, Damien Sanlaville, Sylvie Gory‐Fauré, Eric Denarier, Christophe Porcher, Gaetan Lesca, Igor Medina   +19 more
wiley   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape, Klaus Hopster, Ismar Lutvikadic, Bernd Driessen   +3 more
wiley   +1 more source

Efeitos cardiovasculares da anestesia dissociativa na reposição volêmica com colóide e solução hipertônica em cães: avaliação biotelemétrica Cardiovascular effects of dissociative anesthesia in the volemic expansion with colloid and hypertonic solution in dogs: biotelemetric evaluation

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2009
Avaliaram-se os efeitos cardiovasculares por um período de 24 horas, após a administração de solução salina hipertônica (NaCl) 7,5% ou em associação ao hidroxietilamido 130/0,4 (HES), em cães com hipovolemia induzida e tratados com cetamina levógira ou ...
N. Oleskovicz, J.C.D. Moreno, E.C.P. Guirro, C.A.A. Valadão, D.T. Fantoni   +4 more
doaj   +1 more source

A gut-to-brain signal of fluid osmolarity controls thirst satiation. [PDF]

, 2019
Satiation is the process by which eating and drinking reduce appetite. For thirst, oropharyngeal cues have a critical role in driving satiation by reporting to the brain the volume of fluid that has been ingested1-12.
Ahn, Jamie S, Bai, Ling, Beutler, Lisa R, Chen, Yiming, Corpuz, Timothy V, Huey, Erica L, Knight, Zachary A, Kosar, Seher, Madisen, Linda, Tan, Chan Lek, Zeng, Hongkui, Zimmerman, Christopher A   +11 more
core   +1 more source

Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. [PDF]

, 2016
Electrical membrane properties of skeletal muscle fibers have been thoroughly studied over the last five to six decades. This has shown that muscle fibers from a wide range of species, including fish, amphibians, reptiles, birds, and mammals, are all ...
Chen, Tsung-Yu, de Paoli, Frank Vincenzo, Nielsen, Ole Bækgaard, Pedersen, Thomas Holm, Riisager, Anders   +4 more
core   +1 more source

Pelvic venous disorders in women: Diagnosis and management for gynecologists

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Pelvic venous disorders (PeVD) are an underrecognized yet significant cause of chronic pelvic pain (CPP) in reproductive‐aged women, characterized by venous reflux, obstruction, or both. This clinical opinion provides a practical overview of PeVD for gynecologists, outlining its pathophysiology, common presentations, diagnostic approach, and ...
Tiffany Ni, Inbar Friedman, Jessica Smith, Brian Liu, Mary Melchior, Andrew D. Brown   +5 more
wiley   +1 more source

Avaliação hemodinâmica e metabólica da cetamina e cetamina S(+) após a reposição volêmica com hidroxietilamido 130/0,4 e solução salina hipertônica 7,5% Hemodynamic and metabolic evaluation of ketamine and S(+) ketamine after volemic expansion with hydroxyethyl starch 130/0,4 and hypertonic saline solution

Ciência Rural, 2008
O objetivo deste estudo foi avaliar os efeitos hemodinâmicos e metabólicos, após a administração de solução salina hipertônica (NaCL) 7,5% ou em associação ao hidroxietilamido (HES), em cães com hipovolemia induzida e tratados com cetamina.
Nilson Oleskovicz, Juan Carlos Duque, Erica Cristina Prado Guirro, Carlos Augusto Araújo Valadão, Denise Tabacchi Fantoni   +4 more
doaj   +1 more source