Results 11 to 20 of about 760,497 (383)
The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
International Journal of Molecular Sciences, 2020 Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage.
Yeri Alice Rim, Yoojun Nam, J. Ju
semanticscholar +1 more source
Antioxidants, 2022 Volume-induced hypertrophy is one of the risk factors for cardiac morbidity and mortality. In addition, mechanical and metabolic dysfunction, aging, and cellular redox balance are also contributing factors to the disease progression.
Kamilla Gömöri +17 more
doaj +1 more source
The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation [PDF]
, 2012 Background: Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI). Purpose: The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft ...
Annie Horng +7 more
core +1 more source
MEF2 and the Right Ventricle: From Development to Disease
Frontiers in Cardiovascular Medicine, 2019 Pulmonary arterial hypertension is a progressive and ultimately life-limiting disease in which survival is closely linked to right ventricular function.
Katharine R. Clapham +5 more
doaj +1 more source
Biomolecules, 2022 Hyperthyroidism is common and can induce cardiomyopathy, but there is no effective therapeutic strategy. The purpose of this study was to investigate the molecular mechanism of hyperthyroidism-induced cardiomyopathy (HTC) and the effect of N ...
Mengni Bao +8 more
doaj +1 more source
Cell Death Discovery, 2021 The exact mechanism of myocardial hypertrophy has not been completely elucidated. NOD-like receptor protein 3 (NLRP3) and the pyroptotic cascade play a critical role in cardiac hypertrophy and inflammation. The myokine irisin can inhibit NLRP3 activation,
R. Yue +9 more
semanticscholar +1 more source
Electrocardiographic (ECG) criteria for determining left ventricular mass in young healthy men; data from the LARGE Heart study [PDF]
, 2009 Background: Doubts remain over the use of the ECG in identifying those with increased left ventricular (LV) mass. This is especially so in young individuals, despite their high prevalence of ECG criteria for LV hypertrophy.
Montgomery, HE +5 more
core +2 more sources
Circulation, 2020 Supplemental Digital Content is available in the text. Background: Pressure overload–induced pathological cardiac hypertrophy is a common predecessor of heart failure, the latter of which remains a major cardiovascular disease with increasing incidence ...
Zongna Ren +7 more
semanticscholar +1 more source
Cardiac hypertrophy and heart failure: from the case to review of literature [PDF]
, 2016 In response to an increased workload due to physiological or pathological stimuli, the heart may undergo a process of growth with increased muscle mass called cardiac hypertrophy. It is a particular mechanism of long term compensation used by the heart
Massoni, Francesco +4 more
core +1 more source
Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. [PDF]
, 2013 Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that
An, Woojin +7 more
core +1 more source