Results 11 to 20 of about 528,761 (298)

Altered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy

Antioxidants, 2022
Volume-induced hypertrophy is one of the risk factors for cardiac morbidity and mortality. In addition, mechanical and metabolic dysfunction, aging, and cellular redox balance are also contributing factors to the disease progression.
Kamilla Gömöri, Melissa Herwig, Roua Hassoun, Heidi Budde, Nusratul Mostafi, Simin Delalat, Suvasini Modi, Merima Begovic, Tamara Szabados, Judit Pipis, Nikolett Farkas-Morvay, István Leprán, Árpád Kovács, Andreas Mügge, Péter Ferdinandy, Anikó Görbe, Péter Bencsik, Nazha Hamdani   +17 more
doaj   +1 more source

The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression

International Journal of Molecular Sciences, 2020
Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage.
Yeri Alice Rim, Yoojun Nam, J. Ju
semanticscholar   +1 more source

Resistance Training Recommendations to Maximize Muscle Hypertrophy in an Athletic Population: Position Stand of the IUSCA

International Journal of Strength and Conditioning, 2021
Hypertrophy can be operationally defined as an increase in the axial cross-sectional area of a muscle fiber or whole muscle, and is due to increases in the size of pre-existing muscle fibers. Hypertrophy is a desired outcome in many sports.
B. Schoenfeld, J. Fisher, J. Grgic, Cody T Haun, E. Helms, Stuart M Phillips, J. Steele, A. Vigotsky   +7 more
semanticscholar   +1 more source

MEF2 and the Right Ventricle: From Development to Disease

Frontiers in Cardiovascular Medicine, 2019
Pulmonary arterial hypertension is a progressive and ultimately life-limiting disease in which survival is closely linked to right ventricular function.
Katharine R. Clapham, Inderjit Singh, Isabella S. Capuano, Isabella S. Capuano, Sudarshan Rajagopal, Hyung J. Chun   +5 more
doaj   +1 more source

N-Acetylcysteine, an ROS Inhibitor, Alleviates the Pathophysiology of Hyperthyroidism-Induced Cardiomyopathy via the ROS/Ca²⁺ Pathway

Biomolecules, 2022
Hyperthyroidism is common and can induce cardiomyopathy, but there is no effective therapeutic strategy. The purpose of this study was to investigate the molecular mechanism of hyperthyroidism-induced cardiomyopathy (HTC) and the effect of N ...
Mengni Bao, Xiumeng Hua, Han Mo, Zhe Sun, Bo Xu, Xiao Chen, Mengda Xu, Xinjie Xu, Jiangping Song   +8 more
doaj   +1 more source

Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Pressure overload–induced pathological cardiac hypertrophy is a common predecessor of heart failure, the latter of which remains a major cardiovascular disease with increasing incidence ...
Zongna Ren, Peng Yu, Dandan Li, Zheng Li, Yingnan Liao, Yin Wang, Bingying Zhou, Li Wang   +7 more
semanticscholar   +1 more source

Opposite Effects of Moderate and Extreme Cx43 Deficiency in Conditional Cx43-Deficient Mice on Angiotensin II-Induced Cardiac Fibrosis

Cells, 2019
Connexin 43 (Cx43) is essential for cardiac electrical coupling, but its effects on myocardial fibrosis is controversial. Here, we analyzed the role of Cx43 in myocardial fibrosis caused by angiotensin II (AngII) using Cx43fl/fl and Cx43Cre-ER(T)/fl ...
Laura Valls-Lacalle, Corall Negre-Pujol, Cristina Rodríguez, Saray Varona, Antoni Valera-Cañellas, Marta Consegal, Jose Martínez-González, Antonio Rodríguez-Sinovas   +7 more
doaj   +1 more source

Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy

eLife, 2017
Fusion of skeletal muscle stem/progenitor cells is required for proper development and regeneration, however the significance of this process during adult muscle hypertrophy has not been explored.
Qingnian Goh, Douglas P Millay
doaj   +1 more source

NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin

Cell Death Discovery, 2021
The exact mechanism of myocardial hypertrophy has not been completely elucidated. NOD-like receptor protein 3 (NLRP3) and the pyroptotic cascade play a critical role in cardiac hypertrophy and inflammation. The myokine irisin can inhibit NLRP3 activation,
R. Yue, Zaiyong Zheng, Yu Luo, Xiaobo Wang, Mingming Lv, D. Qin, Q. Tan, Yulong Zhang, Tao Wang, Houxiang Hu   +9 more
semanticscholar   +1 more source

Analysis of microRNA Expression Profiles Induced by Yiqifumai Injection in Rats with Chronic Heart Failure

Frontiers in Physiology, 2018
Background: Yiqifumai Injection (YQFM) is clinically used to treat various cardiovascular diseases including chronic heart failure (CHF). The efficacy of YQFM for treating heart failure has been suggested, but the mechanism of action for pharmacological ...
Yu Zhao, Yunfei Li, Ling Tong, Xinying Liang, Han Zhang, Lan Li, Guanwei Fan, Yi Wang   +7 more
doaj   +1 more source