Results 21 to 30 of about 528,761 (298)
Frontiers in Pharmacology, 2018 Fructus Ligustri Lucidi (FLL) has been widely used as a traditional Chinese medicine (TCM) for treating soreness and weakness of waist and knees. It has potential for treating OA owing to its kidney-tonifying activity with bone-strengthening effects, but
Bo Yan +12 more
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Role of Foxo1 gene expression in mechanism of antihypertrophic action of metformin in cardiomyocytes
Mìžnarodnij Endokrinologìčnij Žurnal, 2018 Background. Diabetic cardiomyopathy is the leading cause of mortality in patients with type 2 diabetes mellitus. Hypertrophy of cardiomyocytes is one of the main pathomorphological signs of diabetic cardiomyopathy development.
N.V. Pasiechko +3 more
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Frontiers in Cell and Developmental Biology, 2019 A major problem with chondrocytes derived in vitro from stem cells is undesired hypertrophic degeneration, to which articular chondrocytes (ACs) are resistant. As progenitors of all adult tissues, induced pluripotent stem cells (iPSCs) are in theory able
Solvig Diederichs +3 more
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Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development
Frontiers in Cell and Developmental Biology, 2021 Osteoarthritis (OA) is a long-term condition that causes joint pain and reduced movement. Notably, the same pathways governing cell growth, death, and differentiation during the growth and development of the body are also common drivers of OA.
Xiwei Fan +6 more
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Adaptations to Post-exercise Cold Water Immersion: Friend, Foe, or Futile?
Frontiers in Sports and Active Living, 2021 In the last decade, cold water immersion (CWI) has emerged as one of the most popular post-exercise recovery strategies utilized amongst athletes during training and competition.
Mohammed Ihsan +3 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundCardiomyocyte‐specific transgenic mice overexpressing S100A6, a member of the family of EF‐hand calcium‐binding proteins, develop less cardiac hypertrophy, interstitial fibrosis, and myocyte apoptosis after permanent coronary ligation, findings
Azadeh Mofid +13 more
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Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise.
Journal of applied physiology, 2019 One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that occurs in response to resistance exercise. A large body of work shows that a mammalian target of rapamycin complex 1 (mTORC1)-mediated increase of muscle protein ...
H. Wackerhage +4 more
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Emerging Roles of Neuronal Ca2+ Sensor-1 in Cardiac and Neuronal Tissues: A Mini Review
Frontiers in Molecular Neuroscience, 2019 The EF-hand calcium (Ca2+)-binding protein, neuronal Ca2+ sensor-1 (NCS-1/frequenin), is predominantly expressed in neuronal tissues and plays a crucial role in neuronal functions, including synaptic transmission and plasticity.
Tomoe Y. Nakamura +4 more
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Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States
Cell Reports, 2020 Summary: Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators.
Tanner Stokes +13 more
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Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise
Cells, 2021 This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 ...
Wenyuan G. Zhu +8 more
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