Results 21 to 30 of about 760,497 (383)

Opposite Effects of Moderate and Extreme Cx43 Deficiency in Conditional Cx43-Deficient Mice on Angiotensin II-Induced Cardiac Fibrosis

Cells, 2019
Connexin 43 (Cx43) is essential for cardiac electrical coupling, but its effects on myocardial fibrosis is controversial. Here, we analyzed the role of Cx43 in myocardial fibrosis caused by angiotensin II (AngII) using Cx43fl/fl and Cx43Cre-ER(T)/fl ...
Laura Valls-Lacalle, Corall Negre-Pujol, Cristina Rodríguez, Saray Varona, Antoni Valera-Cañellas, Marta Consegal, Jose Martínez-González, Antonio Rodríguez-Sinovas   +7 more
doaj   +1 more source

Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy

eLife, 2017
Fusion of skeletal muscle stem/progenitor cells is required for proper development and regeneration, however the significance of this process during adult muscle hypertrophy has not been explored.
Qingnian Goh, Douglas P Millay
doaj   +1 more source

Analysis of microRNA Expression Profiles Induced by Yiqifumai Injection in Rats with Chronic Heart Failure

Frontiers in Physiology, 2018
Background: Yiqifumai Injection (YQFM) is clinically used to treat various cardiovascular diseases including chronic heart failure (CHF). The efficacy of YQFM for treating heart failure has been suggested, but the mechanism of action for pharmacological ...
Yu Zhao, Yunfei Li, Ling Tong, Xinying Liang, Han Zhang, Lan Li, Guanwei Fan, Yi Wang   +7 more
doaj   +1 more source

Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]

, 2015
Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
Burmeister, BT, Carnegie, GK, Gold, MG, O'Bryan, JP, Skidgel, RA, Wang, L   +5 more
core   +1 more source

Intra-Articular Injection of Fructus Ligustri Lucidi Extract Attenuates Pain Behavior and Cartilage Degeneration in Mono-Iodoacetate Induced Osteoarthritic Rats

Frontiers in Pharmacology, 2018
Fructus Ligustri Lucidi (FLL) has been widely used as a traditional Chinese medicine (TCM) for treating soreness and weakness of waist and knees. It has potential for treating OA owing to its kidney-tonifying activity with bone-strengthening effects, but
Bo Yan, Li Zhou, Caiwei Wang, Rongrong Wang, Li Yan, Lingying Yu, Fucun Liu, Wenxi Du, Guangping Yu, Qiang Yuan, Peijian Tong, Letian Shan, Thomas Efferth   +12 more
doaj   +1 more source

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats [PDF]

, 2015
Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in ...
Choisy, Stéphanie C., Choisy, Stéphanie C., Hancox, Jules C., James, Andrew F., Jones, Sandra A., Kim, Shang-Jin   +5 more
core   +1 more source

Role of Foxo1 gene expression in mechanism of antihypertrophic action of metformin in cardiomyocytes

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Background. Diabetic cardiomyopathy is the leading cause of mortality in patients with type 2 diabetes mellitus. Hypertrophy of cardiomyocytes is one of the main pathomorphological signs of diabetic cardiomyopathy development.
N.V. Pasiechko, H.Ya. Loi, M.M. Korda, O.M. Oleshchuk   +3 more
doaj   +1 more source

Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium [PDF]

, 2010
One of the main outcomes of aerobic endurance exercise training is the improved maximal oxygen uptake, and this is pivotal to the improved work capacity that follows the exercise training.
Adams, Adams, American College of Sports Medicine Position Stand, American Heart Association, Amundsen, Anderson, Anversa, Beisvag, Belardinelli, Bergmann, Bers, Beyer, Blair, Blair, Boluyt, Bossuyt, Bye, Care, de Waard, Del Monte, Diffee, Diffee, Diffee, Diffee, Eto, Fletcher, Frampton, Gledhill, Gomez, Gulati, Hambrecht, Hambrecht, Haram, Hasenfuss, Helgerud, Hunter, Iemitsu, Jensen, Jolliffe, Kavanagh, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kodoma, Kong, Kuum, Lankford, Laughlin, Lee, Levine, Liang, Liu, Loennechen, McMullen, Moholdt, Mokelke, Mole, Moore, Musch, Myers, Myles, Nakao, Natali, O’Connor, O’Neill, Paffenbarger, Palmer, Pelliccia, Penpargkul, Pluim, Richardson, Richardson, Rognmo, Saltin, Schaible, Schjerve, Shephard, Stolen, Tanasescu, Tate, Tibbits, Tjonna, Venetucci, Wagner, Wilkins, Wisloff, Wisloff, Wisloff, Wisloff, Wisloff, Wisloff, Zhang, Zhang   +98 more
core   +1 more source

Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway

Frontiers in Cell and Developmental Biology, 2019
A major problem with chondrocytes derived in vitro from stem cells is undesired hypertrophic degeneration, to which articular chondrocytes (ACs) are resistant. As progenitors of all adult tissues, induced pluripotent stem cells (iPSCs) are in theory able
Solvig Diederichs, Felicia A. M. Klampfleuthner, Babak Moradi, Wiltrud Richter   +3 more
doaj   +1 more source

Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development

Frontiers in Cell and Developmental Biology, 2021
Osteoarthritis (OA) is a long-term condition that causes joint pain and reduced movement. Notably, the same pathways governing cell growth, death, and differentiation during the growth and development of the body are also common drivers of OA.
Xiwei Fan, Xiaoxin Wu, Ross Crawford, Ross Crawford, Yin Xiao, Yin Xiao, Indira Prasadam   +6 more
doaj   +1 more source