Results 31 to 40 of about 324,212 (297)
Feline Hypertrophic Cardiomyopathy (FHCM)
Folia Veterinaria, 2022 The feline hypertrophic cardiomyopathy (HCM) is one of many cardiac diseases known in domestic animals, and it is especially frequent in cats of all ages. HCM is the most common heart disease in cats, affecting almost 15 % of the feline population.
Szarková A. +5 more
doaj +1 more source
Heart-Healthy Hypertrophy [PDF]
Cell Metabolism, 2011 Exercise induces growth of heart muscle cells and heart size. A new report in Cell (Boström et al., 2010) suggests that mice also respond to exercise with increased cardiac myocyte proliferation, and the molecular regulators of this pathway are linked to maladaptive and pathologic responses to cardiac stresses such as pressure overload.
Jonathan A. Epstein, Chinmay M. Trivedi
openaire +3 more sources
Hypertrophy of the Brain [PDF]
The Journal of Nervous and Mental Disease, 1907 n ...
openaire +2 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Altered Sarcomeric Structure and Function in Woody Breast Myopathy of Avian Pectoralis Major Muscle
Frontiers in Physiology, 2020 The “Woody” or “Wooden” breast disease is a severe myopathy of pectoralis major muscle recently identified within rapidly growing broiler lines all around the world with a prevalence rate around 20%, or even higher.
Jiao Liu +4 more
doaj +1 more source
Mechanics of chondrocyte hypertrophy [PDF]
Biomechanics and Modeling in Mechanobiology, 2011 Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
van Cc René Donkelaar, W Wouter Wilson
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The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
CAMTA in Cardiac Hypertrophy [PDF]
Cell, 2006 In this issue of Cell, the Calmodulin binding transcription activator 2 (CAMTA2), is shown by Song et al. (2006) to be an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the dissociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction ...
Michael D. Schneider +2 more
openaire +3 more sources
Advanced Biology, EarlyView.The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali +5 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo +13 more
wiley +1 more source