Results 31 to 40 of about 749,882 (394)

Role of Foxo1 gene expression in mechanism of antihypertrophic action of metformin in cardiomyocytes

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Background. Diabetic cardiomyopathy is the leading cause of mortality in patients with type 2 diabetes mellitus. Hypertrophy of cardiomyocytes is one of the main pathomorphological signs of diabetic cardiomyopathy development.
N.V. Pasiechko, H.Ya. Loi, M.M. Korda, O.M. Oleshchuk   +3 more
doaj   +1 more source

Regulation of the mitochondrial transition pore : impact on mammalian aging [PDF]

, 2011
Commentary on: Hafner AV et al. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging.
Osiewacz, Heinz D.
core   +2 more sources

Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway

Frontiers in Cell and Developmental Biology, 2019
A major problem with chondrocytes derived in vitro from stem cells is undesired hypertrophic degeneration, to which articular chondrocytes (ACs) are resistant. As progenitors of all adult tissues, induced pluripotent stem cells (iPSCs) are in theory able
Solvig Diederichs, Felicia A. M. Klampfleuthner, Babak Moradi, Wiltrud Richter   +3 more
doaj   +1 more source

Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]

, 2015
Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M., Baillie, George S., Corsetti, Veronica, Dodoni, Giuliano, Fields, Laura A., Furlan, Leonardo, Gesellchen, Frank, Graham, Delyth, Hamilton, Graham M., Jiang, He, Krall, Judith, Lefkimmiatis, Konstantinos, Livie, Craig, Mancuso, Luisa, Movsesian, Matthew, Nicklin, Stuart A., Sin, Yuan Yan, Sjaastad, Ivar, Stangherlin, Alessandra, Surdo, Nicoletta C., Szabo-Fresnais, Nicolas, Terrin, Anna, Vandeput, Fabrice, Zaccolo, Manuela, Zoccarato, Anna   +24 more
core   +1 more source

Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development

Frontiers in Cell and Developmental Biology, 2021
Osteoarthritis (OA) is a long-term condition that causes joint pain and reduced movement. Notably, the same pathways governing cell growth, death, and differentiation during the growth and development of the body are also common drivers of OA.
Xiwei Fan, Xiaoxin Wu, Ross Crawford, Ross Crawford, Yin Xiao, Yin Xiao, Indira Prasadam   +6 more
doaj   +1 more source

Preliminary definitions for the sonographic features of synovitis in children [PDF]

, 2016
Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first.
Backhaus, M, Balint, P, Bruns, A, Bruyn, Ga, Collado, P, D'Agostino, Ma, De la Cruz, L, Guillaume Czitrom, S, Herlin, T, Hernandez, C, Iagnocco, Annamaria, Jousse Joulin, S, Lanni, S, Lilleby, V, Magni Manzoni, S, Malattia, C, Modesto, C, Naredo, E., Narrodi, A, Nieto, Jc, Ohrndorf, S, Ravagnani, V, Rossi, L, Roth, J, Selvaag, Am, Swen, N, Ting, T, Tzaribachev, N, Vega Fernandez, P, Vojinovic, J, Windschall, D   +30 more
core   +2 more sources

Adaptations to Post-exercise Cold Water Immersion: Friend, Foe, or Futile?

Frontiers in Sports and Active Living, 2021
In the last decade, cold water immersion (CWI) has emerged as one of the most popular post-exercise recovery strategies utilized amongst athletes during training and competition.
Mohammed Ihsan, Mohammed Ihsan, Chris R. Abbiss, Robert Allan   +3 more
doaj   +1 more source

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation [PDF]

, 2014
The goal of the current work was to profile positive (mTORC1 activation, autocrine/paracrine growth factors) and negative [AMPK, unfolded protein response (UPR)] pathways that might regulate overload-induced mTORC1 (mTOR complex 1) activation with the ...
Amy Patton, Andrew Philp, D. Lee Hamilton, Florini JR, Frey JW, Hamilton DL, Iain J. Gallagher, Keith Baar, Matthew G. MacKenzie, Mhairi C. Towler, R Foundation for Statistical Computing, Sue C. Bodine, Zick Y   +12 more
core   +5 more sources

Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise.

Journal of applied physiology, 2019
One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that occurs in response to resistance exercise. A large body of work shows that a mammalian target of rapamycin complex 1 (mTORC1)-mediated increase of muscle protein ...
H. Wackerhage, B. Schoenfeld, D. Hamilton, M. Lehti, J. Hulmi   +4 more
semanticscholar   +1 more source

Lipomatous septal hypertrophy [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2009
A 76-year old obese woman with a body mass index (BMI) of 36.8 was referred for evaluation of an intracardiac mass, incidentally detected with computed tomography (CT). The CT scan showed massive thickening of the intra-atrial septum with the septal tissue clearly hypointense to normal myocardium and isointense to subcutaneous fat (Figure 1, A) and ...
Claudia Plachtzik, Christian S. Haas, Christina Doesch   +2 more
openaire   +3 more sources