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Exploring a Subpopulation of MASLD Associated With New Onset of CKD Using Supervised Clustering Techniques

Hepatology Research, Volume 56, Issue 5, Page 762-777, May 2026.
The supervised clustering of metabolic dysfunction‐associated steatotic liver disease (MASLD) using a SHapley Additive exPlanations (SHAP)‐converted matrix reveals distinct subpopulations that improved risk stratification for new onset of chronic kidney disease (CKD).
Itaru Hosaka +14 more
wiley +1 more source

Nonlinear Association of the Triglyceride–Glucose Index With Hyperuricemia Among Young Chinese Adults

The Journal of Clinical Hypertension, Volume 28, Issue 5, May 2026.
ABSTRACT The triglyceride–glucose (TyG) index is a practical surrogate of insulin resistance, but evidence on its association with hyperuricemia (HUA) in young adults is limited. We examined the nonlinear association between TyG and HUA in a young Chinese population. This cross‐sectional study included 6343 adults aged 18–45 years who underwent routine
Ri Liu, Huian Ge, Chen Qiu, Zetao Wu
wiley +1 more source

ChREBP‐β Exacerbates Renal Tubular Disorders Caused by Fructose via ATF4

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Schematic diagram of the mechanism underlying fructose‐induced renal tubular injury via ChREBP‐β‐mediated disruption of endoplasmic reticulum and mitochondrial homeostasis. This diagram illustrates that fructose induces the transcriptional activation of ChREBP‐β, which subsequently triggers endoplasmic reticulum stress, disturbs inter‐organelle calcium
Ting Fang +7 more
wiley +1 more source

DcR3 suppresses the NF-κB pathway and the NLRP3 inflammasome activation in gouty inflammation