Results 1 to 10 of about 4,456 (153)

Incidence and risk factors of tocilizumab-induced hypofibrinogenemia in patients with thyroid eye disease: a single-center retrospective study [PDF]

Frontiers in Endocrinology
BackgroundTocilizumab, an interleukin-6 receptor antagonist, is increasingly used in moderate-to-severe thyroid eye disease. However, its association with hypofibrinogenemia remains underexplored in this population.MethodsThis single-center retrospective
Ente Wang, Qingyuan Hu, Shanshan Xu, Jianbo Zhou, Jiawei Wang, Zhihui Song, Xinglong Wang   +6 more
doaj   +2 more sources

Development and validation of a risk prediction model for tigecycline-induced hypofibrinogenemia in septic patients: a retrospective cohort study [PDF]

BMC Infectious Diseases
Background Tigecycline is widely used in China to treat multidrug-resistant bacterial infections, with hypofibrinogenemia being the most common adverse effect due to its impact on coagulation.
Hongling Ma, Zhaotang Gong, Jia Sun, LiNa Chen, GuLeng SiRi   +4 more
doaj   +2 more sources

Treatment effects of fibrinogen concentrates vs. cryoprecipitate for correcting hypofibrinogenemia in cardiac surgery patients: a systematic review and meta-analysis [PDF]

Frontiers in Cardiovascular Medicine
BackgroundHypofibrinogenemia in cardiac surgery increases bleeding risk, but the efficacy and safety of fibrinogen concentrate vs. cryoprecipitate remain unclear.
Yue Chen, Wenjie Yang, Chongyang Zhao, Fujue Wang, PengWei Ren, Xuemei Liu, Tingyong Cao, Shuming Ji, Lei Chen, Deying Kang, Deying Kang   +10 more
doaj   +2 more sources

Risk Factors for Tigecycline-Associated Hypofibrinogenemia

Therapeutics and Clinical Risk Management, 2021
Jia Liu,1 Yingying Yan,2 Fan Zhang1 1Department of Geriatrics, Peking University Third Hospital, Beijing, People’s Republic of China; 2Department of Pharmacy, Peking University Third Hospital, Beijing, People’s Republic of ChinaCorrespondence:
Liu J, Yan Y, Zhang F
doaj   +5 more sources

The thrombotic paradox in congenital fibrinogen deficiencies: from pathophysiology to practice [PDF]

Research and Practice in Thrombosis and Haemostasis
Congenital fibrinogen deficiencies (CFDs) comprise rare inherited disorders characterized by quantitative (afibrinogenemia, hypofibrinogenemia) or qualitative (dysfibrinogenemia, hypodysfibrinogenemia) abnormalities of fibrinogen.
Samin Mohsenian, Alessandro Casini, Flora Peyvandi   +2 more
doaj   +2 more sources

Identification of Risk Factors and Predictive Indicators for Tigecycline‐Associated Hypofibrinogenemia [PDF]

Clinical and Translational Science
To investigate the prevalence, clinical manifestations, and risk factors of hypofibrinogenemia after tigecycline use, which can disrupt coagulation and potentially hinder antimicrobial therapy.
Xiaohui Liu, Xuefeng Yuan, Long Wen, Xin Tan, Qian Sui, Jiheng Liu   +5 more
doaj   +2 more sources

Acquired hypofibrinogenemia: current perspectives

Journal of Blood Medicine, 2016
Martin W Besser,1 Stephen G MacDonald2 1Department of Haematology, 2Department of Specialist Haemostasis, The Pathology Partnership, Addenbrooke’s Hospital, Cambridge, UK Abstract: Acquired hypofibrinogenemia is most frequently caused by ...
Besser MW, MacDonald SG
doaj   +4 more sources

Clinical Significance of Rotational Thromboelastometry (ROTEM) for Detection of Early Coagulopathy in Trauma Patients: A Retrospective Study [PDF]

Diagnostics
Background: We aimed to evaluate the clinical significance of abnormal rotational thromboelastometry (ROTEM) findings in trauma patients and investigate the relationships between FIBTEM-maximum clot firmness (MCF), fibrinogen concentration and patient ...
Mohammad Asim, Ayman El-Menyar, Ruben Peralta, Suresh Arumugam, Bianca Wahlen, Khalid Ahmed, Naushad Ahmad Khan, Amani N. Alansari, Monira Mollazehi, Muhamed Ibnas, Ammar Al-Hassani, Ashok Parchani, Talat Chughtai, Sagar Galwankar, Hassan Al-Thani, Sandro Rizoli   +15 more
doaj   +2 more sources

Transient hypofibrinogenemia due to allopurinol

Drug Design, Development and Therapy, 2014
ZhiQiang Yin,1,* JiaLi Xu,2,* YongQiang Li,3,* JiPing Xia,1 Dan Luo1 1Department of Dermatology, 2Department of Oncology, 3Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's ...
Yin ZQ, Xu JL, Li YQ, Xia JP, Luo D
doaj   +5 more sources

Hypofibrinogenemia is associated with a high degree of risk in infectious diseases: a post-hoc analysis of post-marketing surveillance of patients with disseminated intravascular coagulation treated with thrombomodulin alfa

Thrombosis Journal, 2021
Background In patients with infectious diseases, disseminated intravascular coagulation (DIC) is often diagnosed without the fibrinogen value. The relationship between hypofibrinogenemia and outcomes of DIC in infectious diseases has thus remained ...
Kazuo Kawasugi, Hideo Wada, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Seiji Madoiwa, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Toshiaki Iba, Kohji Okamoto   +11 more
doaj   +1 more source