Results 11 to 20 of about 4,456 (153)

Hemophagocytic Lymphohistiocytosis as First Manifestation of Dual B-Cell Neoplasms: A Case Report of Co-Existing Multiple Myeloma and B-Cell Lymphoma. [PDF]

EJHaem
ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder causing excessive inflammation and tissue damage. Lymphoma, especially T‐cell lymphoma, is the most common cause of HLH, while Multiple Myeloma (MM) is rarely associated. We present a 61‐year‐old man with spiking fevers, fatigue, and unintentional weight loss. The HLH was driven by
Romagnoli C, Lyubimova A, Santos-Carrion L, Alloush F, Sriganeshan V, Noboa A, Barrientos JC.   +6 more
europepmc   +2 more sources

Tocilizumab-induced hypofibrinogenemia in patients with systemic-onset juvenile idiopathic arthritis

Scientific Reports, 2023
Systemic juvenile idiopathic arthritis (SJIA) is a chronic inflammatory disease of childhood with elevated serum IL-6 levels. As an inhibitor of IL-6R, tocilizumab (TCZ) has been approved to treat SJIA patients.
Tingyan He, Jiayun Ling, Jun Yang
doaj   +1 more source

Clinical Characteristics of Hospitalized Neonates With Hypofibrinogenemia: A Retrospective Cohort Study

Frontiers in Pediatrics, 2020
Background: Neonatal hypofibrinogenemia is often asymptomatic but can manifest as hemorrhage.Objective: This study was conducted to characterize clinical characteristics of neonates with hypofibrinogenemia and identify factors associated with hemorrhage ...
Weijun Zhou, Yichun He, Qin Li, Ying Li, Yongchun Su, Li Yan   +5 more
doaj   +1 more source

Congenital Hypofibrinogenemia in a Neonate with a Novel Mutation in the FGB Gene

Pediatric Reports, 2021
Detection of severe hypofibrinogenemia (
Jun Shinozuka, Nobuo Okumura, Mayumi Nagasawa, Motokazu Nishikado, Sayaka Kadowaki, Itsuro Katsuda, Shinsaku Imashuku   +6 more
doaj   +1 more source

Gastrointestinal bleeding after endoscopic mucosal resection in a case of Peutz–Jeghers syndrome with hypofibrinogenemia: A case report

Frontiers in Pediatrics, 2022
BackgroudPeutz–Jegers syndrome (PJS) is an autosomal dominant hereditary disorder characterized by hamartomatous polyposis of the entire gastrointestinal tract.
Toshihiko Kakiuchi, Hironobu Takedomi, Takashi Akutagawa, Nanae Tsuruoka, Yasuhisa Sakata, Muneaki Matsuo   +5 more
doaj   +1 more source

Preeclampsia complicated with hypofibrinogenemia: 2 case reports and review of the literature

BMC Pregnancy and Childbirth, 2023
Background Preeclampsia complicated with hypofibrinogenemia is a rare disorder. We report two cases of severe preeclampsia complicated with hypofibrinogenemia followed by postpartum haemorrhage (PPH).
Shiguang Li, Yanhui Jin, Yanmin Gong, Xia Luo   +3 more
doaj   +1 more source

Case Report: Co‐Occurrence of Lung Adenocarcinoma and Congenital Dysfibrinogenemia—Diagnostic and Perioperative Management Challenges [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Congenital dysfibrinogenemia (CD), a rare autosomal dominant coagulation disorder, poses significant perioperative challenges in oncologic surgery due to hypofibrinogenemia and variable bleeding‐thrombosis risks. Case A 67‐year‐old woman presented with a 2.9 × 1.4 cm spiculated mass in the right middle lobe (RML) and persistent ...
Zheng H, Wang Q, Wang M, Luo S, Ma Y, Wan Z.   +5 more
europepmc   +2 more sources

Incidence, characteristics and risk factors of hypofibrinogenemia associated with tigecycline: A multicenter retrospective study in China

Frontiers in Pharmacology, 2022
Background: Tigecycline was recently found to cause coagulation disorders, especially hypofibrinogenemia, which may interfere with the administration of antimicrobial therapy.
Bing Leng, Chengwu Shen, Tiantian Gao, Kai Zhao, Xuemei Zhao, Yujin Guo, Jiyong Wu, Jing Yang, Wei Fang, Jicheng Zhang, Yahui Zhang, Chao Sun, Lei Duan, Jing Huang, Yougang Qi, Genquan Yan   +15 more
doaj   +1 more source

Pediatric Fibrinogen PART II—Overview of Indications for Fibrinogen Use in Critically Ill Children

Frontiers in Pediatrics, 2021
Bleeding is frequently seen in critically ill children and is associated with increased morbidity and mortality. Fibrinogen is an essential coagulation factor for hemostasis and hypofibrinogenemia is an important risk factor for bleeding in pediatric and
Gemma Louise Crighton, Elise J. Huisman, Elise J. Huisman, Elise J. Huisman   +3 more
doaj   +1 more source

Addressing some challenges of congenital fibrinogen disorders in 2023 and beyond

Bleeding, Thrombosis and Vascular Biology, 2023
Congenital fibrinogen disorders (CFD) include several types and subtypes of fibrinogen deficiency, resulting from monoallelic or biallelic mutations in one of the three fibrinogen genes. While it is relatively easy to make an accurate diagnosis based on
Cristina Santoro, Alessandro Casini
doaj   +3 more sources