Results 21 to 30 of about 4,456 (153)

Sintilimab, a PD-1 Inhibitor, Completely Reversed Rarely Refractory Hypofibrinogenemia in a Gastric Cancer Patient: A Case Report and Review of the Literature

Frontiers in Oncology, 2020
While cancer is often related to hyperfibrinogenemia, it is rarely related to hypofibrinogenemia. Specifically, gastric cancer concomitant with unprovoked hypofibrinogenemia and the corresponding treatment approach have been rarely reported. We presented
Shuzhen Ma, Shuzhen Ma, Qi Dang, Qi Dang, Yali Yang, Yongliang Liu, Yongliang Liu, Yuping Sun, Yuping Sun, Meili Sun, Meili Sun   +10 more
doaj   +1 more source

SEVERE HYPOFIBRINOGENEMIA IN A PATIENT WITH GIANT CELL ARTERITIS TREATED WITH TOCILIZUMAB: CASE-BASED REVIEW

Anti-Aging Eastern Europe, 2023
The Giant cell arteritis (GCA) is the most common form of systemic vasculitis in elderly patients. The treatment includes high doses of steroids and interleukin (IL)-6 inhibitor tocilizumab, especially in refractory or relapsing disease or in cases where
Željka Kardum, Ana Šimac, Kristina Frketić Marović, Ana Marija Masle, Jasminka MIlas Ahić   +4 more
doaj   +1 more source

Women With Congenital Hypofibrinogenemia/Afibrinogenemia: From Birth to Death

Clinical and Applied Thrombosis/Hemostasis, 2020
Congenital fibrinogen disorders are a group of most frequent rare coagulation disorder, characterized by deficiency and/or defects in the fibrinogen molecule. Quantitative disorders include hypofibrinogenemia and afibrinogenemia.
Yan Zhang MD, Xiaohang Zuo MD, Yue Teng PhD, MD   +2 more
doaj   +1 more source

Hereditary Hypofibrinogenemia with Hepatic Storage [PDF]

International Journal of Molecular Sciences, 2020
Fibrinogen is a 340-kDa plasma glycoprotein constituted by two sets of symmetrical trimers, each formed by the Aα, Bβ, and γ chains (respectively coded by the FGA, FGB, and FGG genes). Quantitative fibrinogen deficiencies (hypofibrinogenemia, afibrinogenemia) are rare congenital disorders characterized by low or unmeasurable plasma fibrinogen antigen ...
Rosanna Asselta, Elvezia Maria Paraboschi, Stefano Duga   +2 more
openaire   +2 more sources

Congenital Afibrinogenemia and Hypofibrinogenemia: Laboratory and Genetic Testing in Rare Bleeding Disorders with Life-Threatening Clinical Manifestations and Challenging Management

Diagnostics, 2021
Congenital fibrinogen disorders are rare pathologies of the hemostasis, comprising quantitative (afibrinogenemia, hypofibrinogenemia) and qualitative (dysfibrinogenemia and hypodysfibrinogenemia) disorders. The clinical phenotype is highly heterogeneous,
Tomas Simurda, Rosanna Asselta, Jana Zolkova, Monika Brunclikova, Miroslava Dobrotova, Zuzana Kolkova, Dusan Loderer, Ingrid Skornova, Jan Hudecek, Zora Lasabova, Jan Stasko, Peter Kubisz   +11 more
doaj   +1 more source

Pediatric Fibrinogen PART I—Pitfalls in Fibrinogen Evaluation and Use of Fibrinogen Replacement Products in Children

Frontiers in Pediatrics, 2021
Fibrinogen is a key coagulation protein, playing a critical role in hemostasis. It is the first factor to decrease to critical levels during bleeding. Hypofibrinogenemia is an important risk factor for bleeding in clinical settings, including pediatric ...
Elise J. Huisman, Elise J. Huisman, Elise J. Huisman, Gemma Louise Crighton   +3 more
doaj   +1 more source

Case Report: Life-Threatening Post-operative Hemorrhage in Klippel–Trenaunay Syndrome Associated With Hypofibrinogenemia

Frontiers in Medicine, 2021
Klippel–Trenaunay Syndrome (KTS) is a rare congenital disorder, characterized by venous and lymphatic malformations of the skin, soft tissue, and bone, causing limb hypertrophy.
Hongna Yang, Binfeng Du, Han Liu, Yong Yao, Chen Li   +4 more
doaj   +1 more source

Angiosarcoma of the breast with hypofibrinogenemia: A rare case report and review of the literature

Frontiers in Oncology, 2022
BackgroundBreast angiosarcoma is a rare malignant tumor, accounting for approximately 0.04% of all breast malignancies. Angiosarcoma of the breast with hypofibrinogenemia is even rarer and has not been described in man.
Ran An, Jing-Yi Ma, Xi-Hao Ni, Chang-Liang Wang   +3 more
doaj   +1 more source

Hepatic fibrinogen storage disease due to the fibrinogen γ375 Arg → Trp mutation "fibrinogen aguadilla" is present in Arabs

The Saudi Journal of Gastroenterology, 2014
The mutation γ375Arg → Trp (fibrinogen Aguadilla) is one of four mutations (Brescia, Aguadilla, Angers, and AI duPont) capable of causing hepatic storage of fibrinogen.
Abdulrahman Al-Hussaini, Abdulhadi Altalhi, Imad El Hag, Hussa AlHussaini, Paola Francalanci, Isabella Giovannoni, Francesco Callea   +6 more
doaj   +1 more source

Hemostatic abnormalities at the time of fetal death: A retrospective study evaluating the prevalence and relevance of targeted testing

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To assess the prevalence of hemostasis abnormalities at the time of fetal death diagnosis. Methods This retrospective single‐center study included all fetal deaths between 22 and 42 weeks from July 2017 to December 2023, excluding multiple pregnancies, patients on anticoagulant therapy, and those with known pre‐existing coagulation ...
Chloé Lieng, Catherine Fischer, Aude Girault   +2 more
wiley   +1 more source