Results 51 to 60 of about 4,456 (153)

Thrombotic and Hemorrhagic Complications in the Treatment of Acute Lymphoblastic Leukemia with L-Asparaginase

Клиническая онкогематология, 2018
The article provides a literature review on the use of the L-asparaginase (ASP) in acute lymphoblastic leukemia (ALL) and describes two clinical cases.
Gennadii Martinovich Galstyan, O. A. Polevodova, A. V. Bazhenov, V. V. Troitskaya, O. A. Gavrilina, D. G. Gitel’zon, A. E. Vasil’ev, E. N. Parovichnikova   +7 more
doaj   +1 more source

Predictive value of rotational thromboelastometry during cardiopulmonary bypass for thrombocytopenia and hypofibrinogenemia after weaning of cardiopulmonary bypass [PDF]

Korean Journal of Anesthesiology, 2015
BackgroundThe early detection of coagulopathy helps guide decisions regarding optimal transfusion management during cardiac surgery. This study aimed to determine whether rotational thromboelastometry (ROTEM) analysis during cardiopulmonary bypass (CPB ...
Sung-Mi Ji, Sung-Hoon Kim, Jae-Sik Nam, Hye-Joo Yun, Jeong-Hyun Choi, Eun-Ho Lee, In-Cheol Choi   +6 more
doaj   +1 more source

Interferon‐gamma blocking as a promising treatment for severe liver dysfunction in secondary hemophagocytic lymphohistiocytosis after liver transplantation

JPGN Reports, Volume 7, Issue 1, Page 14-18, February 2026.
Abstract Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening hyperinflammatory syndrome that can occur after solid organ transplantation but remains underrecognized in this setting. The diagnosis is often delayed due to overlapping clinical manifestations with infection, rejection, or malignancy, and management becomes particularly ...
Chen Chen, Tao Zhou, Jing Jin, Yi Luo, Lijing Shen, Qiang Xia, Yongbing Qian   +6 more
wiley   +1 more source

Fibrinogen deficiency in a dog - a case report

BMC Veterinary Research, 2017
Background Among coagulation disorders, primary fibrinogen deficiency is very rare in dogs. It is divided into hypofibrinogenemia, afibrinogenemia and dysfibrinogenemia. Afibrinogenemia has been described in three dogs.
Franck Jolivet, Armelle Diquélou, Catherine Trumel, Simon Privat, Olivier Dossin   +4 more
doaj   +1 more source

Hepatic fibrinogen storage disease and hypofibrinogenemia caused by fibrinogen Aguadilla mutation: a case report

Journal of International Medical Research, 2020
Hepatic fibrinogen storage disease is a rare autosomal dominant genetic disorder characterized by hypofibrinogenemia, as well as the retention of variant fibrinogen within the hepatocellular endoplasmic reticulum. Here, we describe an asymptomatic 4-year-
Leilei Gu, Bin Wang, Lu Liu, Qiaorong Gan, Xiaolong Liu, Lihong Chen, Li Chen   +6 more
doaj   +1 more source

T‐Cell–Redirecting Immunotherapies in Relapsed/Refractory Mantle Cell Lymphoma: Current Evidence, Sequencing, and Future Directions

European Journal of Haematology, Volume 116, Issue 2, Page 129-141, February 2026.
ABSTRACT Relapsed/refractory (R/R) mantle cell lymphoma (MCL) remains a therapeutic challenge, particularly in patients with high‐risk features or prior exposure to Bruton's tyrosine kinase inhibitors (BTKis). The advent of T‐cell–redirecting immunotherapies, including chimeric antigen receptor T‐cell (CAR‐T) therapy and bispecific antibodies (BsAbs ...
Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Massimo Gentile   +10 more
wiley   +1 more source

Retention of critical platelet hemostatic functions of amotosalen‐UVA pathogen‐reduced cryoprecipitated fibrinogen complex

Transfusion, Volume 66, Issue 2, Page 393-404, February 2026.
Abstract Background Cryoprecipitate Anti‐Haemophilic Factor (CRYO‐AHF) is enriched for fibrinogen, VWF, FVIII, FXIII and fibronectin, but has short post‐thaw expiration due to risk of transfusion‐transmitted infection (TTI) limiting availability for rapid treatment.
Florian Tupin, Clarisse Mouriaux, Michelle Gatmaitan, Kaja Kaastrup, Subramanian Yegneswaran, Laurence Corash, Pierre H. Mangin   +6 more
wiley   +1 more source

Fibrinogen Columbus: a novel gamma Gly200Val mutation causing hypofibrinogenemia in a family with associated thrombophilia

Haematologica, 2007
Fibrinogen is an essential component of the coagulation cascade and the acute phase response. The native 340 kDa molecule has a symmetrical trinodular structure composed of a central E-domain connected to outer D-domains by triple helical coiled-coils.1 ...
Ryan L. Davis, Michael W. Mosesson, Bryce A. Kerlin, Jason A. Canner, Frederick B. Ruymann, Stephen O. Brennan   +5 more
doaj   +1 more source

Optimizing Asparaginase Treatment for Adolescent and Young Adult (AYA) Patients With Acute Lymphoblastic Leukemia: US Consensus Panel Recommendations

American Journal of Hematology, Volume 101, Issue 1, Page 41-55, January 2026.
ABSTRACT Asparaginase is an integral component of therapy for pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma. The success of asparaginase‐containing regimens has led to trials of pediatric/pediatric‐inspired regimens incorporating asparaginase for treating adolescent and young adult (AYA) and adult populations with acute ...
Ibrahim Aldoss, Amir Ali, Ryan D. Cassaday, Emily K. Curran, Marlise R. Luskin, Luke D. Maese, Etan Orgel, Dan Douer   +7 more
wiley   +1 more source

Dysfibrinogenemia and hypofibrinogenemia - Spectrum of pathogenic variants in Slovak patients

Biomedical Papers
Introduction. Congenital hypofibrinogenemia (CH) and congenital dysfibrinogenemia (CD) are rare coagulation disorders caused by quantitative or qualitative defects in the fibrinogen gene.
Dominika Jaraskova, Jan Chandoga, Angelika Batorova, Tatiana Prigancova, Miriama Juhosova, Pavol Durina, Alzbeta Vavrova, Silvia Dallemule, Robert Petrovic, Anna Kyselova, Denisa Jankovicova, Daniel Bohmer   +11 more
doaj   +1 more source