Secondary antibody deficiencies in the modern era: emerging trends, diagnostic pitfalls, and advances in personalised management [PDF]
Frontiers in ImmunologySecondary antibody deficiencies (SADs) are a significant but frequently under-recognised group of acquired immunodeficiencies. They may arise in various clinical settings, including haematological malignancies, immunosuppressive therapies, and protein ...
Shuayb Elkhalifa +8 more
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A Misleading Diagnosis of Sarcoidosis in an Older Woman [PDF]
European Journal of Case Reports in Internal Medicine, 2017 Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency and has a reported prevalence of approximately 1:25,000 to 1:50,000.
Abire Allaoui +5 more
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Good’s syndrome revealed by recurrent sigmoid diverticulitis [PDF]
European Journal of Case Reports in Internal MedicineThymus is a primary lymphoid organ whose main function is the education of the T lymphocytes. Thymoma is uncommon neoplasia derived from epithelial cells of the thymus. Patients with thymoma frequently present with autoimmune disorders, mostly myasthenia
Hassene Attout +4 more
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Comparison of rituximab induction and maintenance regimens in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: PK/PD modelling of ANCA and gammaglobulin levels in real-world patientsResearch in context [PDF]
EBioMedicineSummary: Background: We aimed to provide pharmacokinetic-pharmacodynamic (PK/PD) rationale for selecting the optimal induction and maintenance dosing regimens in ANCA-associated vasculitis (AAV) using a population modelling approach based on PK, ANCA ...
Blaise Pasquiers +11 more
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Aspergillus suppurative thyroiditis in the setting of hypogammaglobulinaemia [PDF]
European Journal of Case Reports in Internal MedicineThyroiditis is a condition characterised by the inflammation of the thyroid gland. Most cases of suppurative thyroiditis are caused by aerobic bacteria and present acute onset of symptoms. Hypogammaglobulinaemia associated with suppurative thyroiditis is
Thuy Hao Nguyen +3 more
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Daratumumab for autoimmune diseases: a systematic review [PDF]
RMD Open, 2023 Objective Refractory autoimmune diseases remain a significant challenge in clinical practice and new therapeutic options are needed. This systematic review evaluates the existing reported data on the CD38-targeting antibody daratumumab as a new ...
Martin Krusche +5 more
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Case Report: A simple case of drug-induced secondary antibody deficiency or a rare primary immune deficiency? [PDF]
Frontiers in ImmunologyAntibody deficiency may be primary, because of an underlying inborn error of immunity, or secondary, due to another disease process or medication, leading to decreased antibody production or increased antibody loss.
Sarah L. Johnston +3 more
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Variation in immunoglobulin use and impact on survival in myeloma [PDF]
eJHaemSerious infection is common in patients with multiple myeloma due to immune deficiency from the underlying disease and/or its treatment. Immunoglobulin replacement is one approach to reduce infection risk in these patients.
Khai Li Chai +31 more
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Association between thymoma and persistent hypothermia: a case report [PDF]
Journal of Medical Case Reports, 2009 Introduction Thymomas are rare, slow-growing tumours that present in a variety of ways such as incidental findings on chest radiographs following symptoms of cough and dyspnoea.
Johns Robin H, Reinhardt Alistair K
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Exploration of adverse event profiles for glofitamab: A disproportionality analysis using the FDA adverse event reporting system. [PDF]
PLoS ONEBackgroundGlofitamab offers a promising option for the treatment of diffuse large B-cell lymphoma. It is crucial to gather comprehensive safety information of glofitamab through large-scale post market monitoring.MethodsThis study conducted a ...
Meng Zhou, Cheng Jiang, Chuanyong Su
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