Results 51 to 60 of about 189,446 (330)

Permeation Enhancer‐based Ionogel Shows Remarkable Potential for Oral Insulin Delivery

Advanced Healthcare Materials, EarlyView.
This study proposes a novel formulation of decanoate in an ionic liquid inspired drug delivery system. The formulation demonstrates ideal physicochemical and material properties for oral peptide delivery. Findings indicate that choline decanoate (1:2 molar ratio) forms a viscoelastic gel that enables high oral bioavailability of insulin in rats ...
Konstantinos Raptis, Joanne Heade, Cristiana Cunha, Marco van de Weert, Lasse Saaby, Stine Rønholt, Hanne Mørck Nielsen   +6 more
wiley   +1 more source

Hypoglycemia: Updates on Diagnosis and Treatment

Jurnal Ilmu Kesehatan Indonesia
Hypoglycemia is a condition where blood glucose concentration decreases below 70 mg/dL with or without signs or symptoms. Hypoglycemia symptoms may vary from mild to life-threatening conditions, or be classified based on the severity as mild-moderate and
Dinda Aprilia
doaj   +1 more source

Hypoglycemia: The neglected complication

Indian Journal of Endocrinology and Metabolism, 2013
Hypoglycemia is an important complication of glucose-lowering therapy in patients with diabetes mellitus. Attempts made at intensive glycemic control invariably increases the risk of hypoglycemia.
Sanjay Kalra, Jagat Jyoti Mukherjee, Subramanium Venkataraman, Ganapathi Bantwal, Shehla Shaikh, Banshi Saboo, Ashok Kumar Das, Ambady Ramachandran   +7 more
doaj   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Decreased branched-chain amino acids and elevated fatty acids during antecedent hypoglycemia in type 1 diabetes

BMJ Open Diabetes Research & Care, 2023
Introduction Hypoglycemia is a major limiting factor in achieving recommended glycemic targets for people with type 1 diabetes. Exposure to recurrent hypoglycemia results in blunted hormonal counter-regulatory and symptomatic responses to hypoglycemia ...
Ulrik Pedersen-Bjergaard, Cristina Legido-Quigley, Rui She, Naba Hassan Al-sari, Ismo Matias Mattila, Anne-Sophie Sejling, Jens Pedersen   +6 more
doaj   +1 more source

Dual Foreign Body Response Mitigation Strategies for Implantable Glucose Sensors

Advanced Sensor Research, EarlyView.
The foreign body response negatively impacts the analytical lifetime of implantable glucose sensors due to a heightened immune response and deposition of collagen. While nitric oxide release has shown promise as a foreign body response mitigation strategy, improvement is limited by the duration of release.
Taron M. Bradshaw, Mikaylin E. Nogler, Matthew F. Warchol, Micah L. Willis, Alejandro R. Walker, Robert Maile, Shannon M. Wallet, Elizabeth P. Merricks, Timothy C. Nichols, Mark H. Schoenfisch   +9 more
wiley   +1 more source

Validation of ICD-9-CM coding algorithm for improved identification of hypoglycemia visits

BMC Endocrine Disorders, 2008
Background Accurate identification of hypoglycemia cases by International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes will help to describe epidemiology, monitor trends, and propose interventions for this important ...
Lieberman Rebecca M, Blanc Phillip G, Ginde Adit A, Camargo Carlos A   +3 more
doaj   +1 more source

Hypoglycemia in Mitochondrial Disorders [PDF]

, 2019
INTRODUCTION: The electron transport chain (ETC) in mitochondria functions to produce energy in the form of adenosine triphosphate (ATP). Defects in the mitochondrial or nuclear DNA that codes for components of the ETC lead to mitochondrial disorders ...
Moats, Allison
core   +1 more source

A Bead‐Based Quantum Dot Immunoassay Integrated with Multi‐Module Microfluidics Enables Real‐Time Multiplexed Detection of Blood Insulin and Glucagon

Advanced Science, EarlyView.
The quantum dot integrated real‐time ELISA or QIRT‐ELISA system integrates a bead‐based quantum dot‐mediated immunoassay (BQI) with a modular microfluidic system to continuously monitor insulin and glucagon in whole blood samples and in a multiplexed setting.
Hesam Abouali, Sanjana Srikant, Md Fahim Al Fattah, Nicole G. Barra, Darryl Chan, Dayan Ban, Jonathan D. Schertzer, Mahla Poudineh   +7 more
wiley   +1 more source

Clustering of Hypoglycemia Events in Patients With Hyperinsulinism: Extension of the Digital Phenotype Through Retrospective Data Analysis

Journal of Medical Internet Research, 2021
BackgroundHyperinsulinism (HI) due to excess and dysregulated insulin secretion is the most common cause of severe and recurrent hypoglycemia in childhood.
Chris Worth, Simon Harper, Maria Salomon-Estebanez, Elaine O'Shea, Paul W Nutter, Mark J Dunne, Indraneel Banerjee   +6 more
doaj   +1 more source