Results 81 to 90 of about 197,099 (333)

Comparison of glycemic excursion in patients with new onset type 2 diabetes mellitus before and after treatment with repaglinide [PDF]

, 2013
Due to industrialization and sedentary life, incidence of type 2 diabetes (DM2) is increasing seriously. Repaglinide is a glucose reducing agent that predominantly reduces post-prandial glucose.
Bonakdaran, S., Hezarkhani, S., Marjani, A., Rajabian, R., Shahini, N.   +4 more
core   +1 more source

Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation

Advanced Science, EarlyView.
Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.
Huanyi Liu, Hao Wu, Ziyu Zhang, Shiwen Xu, Cong Zhou, Tong Xu   +5 more
wiley   +1 more source

The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies

Critical Care, 2023
Background Withholding parenteral nutrition (PN) until one week after PICU admission facilitated recovery from critical illness and protected against emotional and behavioral problems 4 years later.
Jan Gunst, Astrid De Bruyn, An Jacobs, Lies Langouche, Inge Derese, Karolijn Dulfer, Fabian Güiza, Gonzalo Garcia Guerra, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen, Ilse Vanhorebeek, Greet Van den Berghe   +12 more
doaj   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Effects of pre-exercise carbohydrate consumption on metabolism during exercise [PDF]

, 2016
It is well documented that consuming carbohydrates (CHO) prior to exercise has been shown to alter metabolism. There are many ways that CHO ingestion affects substrate utilization and blood glucose dynamics at the start of exercise.
Montzingo, Luke James
core   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

A novel therapeutic strategy for pancreatic neoplasia using a novel RNAi platform targeting PDX-1 [PDF]

, 2011
Bi-functional shRNA (bi-shRNA), a novel RNA interference (RNAi) effector platform targeting PDX-1 utilizing a systemic DOTAP-Cholesterol delivery vehicle, was studied in three mouse models of progressive pancreatic neoplasia.
Charles Brunicardi, David Dawson, Donald Rao, Francesco DeMayo, John Nemunaitis, Kelly Stehling, Marie-Claude Gingras, Michael Norman, Nancy Templeton, Neil Senzer, Richard Gibbs, Shi-He Liu, William Fisher, Zhaohui Wang   +13 more
core   +1 more source

Genomic landscapes and clonality of de novo AML [PDF]

, 2013
No abstract ...
Brewin, John, Chevassut, Timothy, Horne, Gillian   +2 more
core   +1 more source

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li, Eduardo H. Gilglioni, Wadsen St‐Pierre‐Wijckmans, Leila Hosseinzadeh, Christelle Veyrat‐Durebex, Sumeet Pal Singh, Roberto Coppari, Latifa Bakiri, Esteban N. Gurzov   +8 more
wiley   +1 more source

The Effect of Bariatric Surgery on Diabetic Retinopathy: Good, Bad, or Both? [PDF]

, 2016
Bariatric surgery, initially intended as a weight-loss procedure, is superior to standard lifestyle intervention and pharmacological therapy for type 2 diabetes in obese individuals.
Docherty, NG, Gorman, DM, Le Roux, CW
core   +3 more sources