Results 81 to 90 of about 165,886 (364)

Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway

Advanced Science, Volume 12, Issue 13, April 3, 2025.
In intestinal epithelial cells, Gastrin/CCKBR stimulation prevents high glucose‐stimulated SGLT1 (SLC5A1) and GLUT2 (SLCA2) expressions, via the PI3K/AKT/eIF4B signaling pathway, with facilitatory effects on the secretion of incretins, which could be therapeutic targets for clinical treatment in T2D.
Xue Liu, Xing Liu, Yunpeng Liu, Anxiong Long, Wei Liu, Shiyun Sun, Shuaibing Lu, Xianxian Wu, Xiaodi Jia, Pedro A Jose, Qiang Wei, Xiaoliang Jiang, Haizeng Zhang, Zhiwei Yang   +13 more
wiley   +1 more source

Causes of hypoglycemia

Journal of Education, Health and Sport, 2019
Tywanek Ewa, Trojanowska Paulina, Woźniak Magdalena, Wronecki Jakub, Zwolak Agnieszka, Łuczyk Robert Jan. Causes of hypoglycemia. Journal of Education, Health and Sport. 2019;9(9):905-911. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3460625 http://ojs.ukw.edu.pl/index.php/johs/article/view/7514 The journal has had 5 points in Ministry of ...
Ewa Tywanek, Agnieszka Zwolak, Magdalena Maria Woźniak, Paulina Trojanowska, Robert Łuczyk, Jakub Wronecki   +5 more
openaire   +3 more sources

Basal-Bolus Advisor for Type 1 Diabetes (T1D) Patients Using Multi-Agent Reinforcement Learning (RL) Methodology [PDF]

arXiv, 2023
This paper presents a novel multi-agent reinforcement learning (RL) approach for personalized glucose control in individuals with type 1 diabetes (T1D). The method employs a closed-loop system consisting of a blood glucose (BG) metabolic model and a multi-agent soft actor-critic RL model acting as the basal-bolus advisor.
arxiv  

Hypoglycemia‐associated autonomic failure, counterregulatory responses, and therapeutic options in type 1 diabetes

Annals of the New York Academy of Sciences, 2019
Hypoglycemia remains a major barrier to the achievement of target levels of glycemic control for most individuals with insulin‐dependent type 1 diabetes (T1D).
M. Rickels
semanticscholar   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Hypoglycemia in blood glucose level in type 2 diabetic Japanese patients by continuous glucose monitoring

Diabetology & Metabolic Syndrome, 2019
Background Hypoglycemia is associated with cardiovascular diseases, increased risk of death. Therefore, it is important to avoid hypoglycemia. The aim of this study was to characterize hypoglycemia according to glycated hemoglobin (HbA1c) level and ...
Maiko Hajime, Yosuke Okada, Hiroko Mori, Fumi Uemura, Satomi Sonoda, Kenichi Tanaka, Akira Kurozumi, Manabu Narisawa, Keiichi Torimoto, Yoshiya Tanaka   +9 more
doaj   +1 more source

The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies

Critical Care, 2023
Background Withholding parenteral nutrition (PN) until one week after PICU admission facilitated recovery from critical illness and protected against emotional and behavioral problems 4 years later.
Jan Gunst, Astrid De Bruyn, An Jacobs, Lies Langouche, Inge Derese, Karolijn Dulfer, Fabian Güiza, Gonzalo Garcia Guerra, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen, Ilse Vanhorebeek, Greet Van den Berghe   +12 more
doaj   +1 more source

Challenging common bolus advisor for self-monitoring type-I diabetes patients using Reinforcement Learning [PDF]

arXiv, 2020
Patients with diabetes who are self-monitoring have to decide right before each meal how much insulin they should take. A standard bolus advisor exists, but has never actually been proven to be optimal in any sense. We challenged this rule applying Reinforcement Learning techniques on data simulated with T1DM, an FDA-approved simulator developed by ...
arxiv  

Impact of CGM on the Management of Hypoglycemia Problems: Overview and Secondary Analysis of the HypoDE Study

Journal of Diabetes Science and Technology, 2019
Hypoglycemia remains the limiting factor of near-normal glucose control in people with diabetes using insulin therapy. Continuous glucose monitoring (CGM) may be able to avoid hypoglycemia and support the management of hypoglycemia problems in clinical ...
N. Hermanns, L. Heinemann, G. Freckmann, D. Waldenmaier, D. Ehrmann   +4 more
semanticscholar   +1 more source

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source