Results 21 to 30 of about 136,109 (177)

Autonomic dysfunction and insulin resistance in type 2 diabetes mellitus with hypoglycemia unawareness: an observational study. [PDF]

Cardiovasc Endocrinol Metab
Purpose To evaluate the association between hypoglycemia unawareness, cardiac autonomic function, and insulin resistance in individuals with type2 diabetes, and explore potential correlations between autonomic dysfunction and metabolic parameters ...
Nandi D, Gupta S, Ajmera N, Selvaraj R, Gulati S, Zaheer S, Tomar A.   +6 more
europepmc   +4 more sources

Hypoglycemia unawareness prevention: Targeting glucagon production. [PDF]

Physiol Behav, 2016
Insulin-dependent individuals with diabetes are at risk for a severe hypoglycemic event that may predispose them to several repeat episodes during which the normal counter regulatory mechanisms that protect against hypoglycemia fail to be activated. This state of hypoglycemia unawareness is characterized by a failure of glucagon release, preventing ...
Samson WK, Stein LM, Elrick M, Salvatori A, Kolar G, Corbett JA, Yosten GL.   +6 more
europepmc   +5 more sources

Hypoglycemia Unawareness in Insulinoma Revealed with Flash Glucose Monitoring Systems. [PDF]

Intern Med, 2018
The delayed diagnosis of insulinoma remains a clinical issue. One of the main causes of such a delay is hypoglycemia unawareness. A 53-year-old woman fell unconscious during postprandial exercises.
Sugawa T, Murakami T, Yabe D, Kashima R, Tatsumi M, Ooshima S, Joo E, Wada K, Yoshizawa A, Masui T, Nakamoto Y, Yamauchi Y, Kodama Y, Iemura Y, Ogura M, Yasoda A, Inagaki N.   +16 more
europepmc   +4 more sources

Hypoglycemia Unawareness and Recurrent Severe Hypoglycemia in an Individual With Type 1 Diabetes Mellitus on Insulin. [PDF]

AACE Clin Case Rep
Escudero C, Husain A, Arnaout A.
europepmc   +4 more sources

Mechanisms of hypoglycemia unawareness and implications in diabetic patients. [PDF]

World J Diabetes, 2015
Hypoglycemia unawareness (HU) is defined at the onset of neuroglycopenia before the appearance of autonomic warning symptoms. It is a major limitation to achieving tight diabetes and reduced quality of life. HU occurs in approximately 40% of people with type 1 diabetes mellitus (T1DM) and with less frequency in T2DM.
Martín-Timón I, Del Cañizo-Gómez FJ.
europepmc   +6 more sources

Automated Insulin Delivery for Hypoglycemia Avoidance and Glucose Counterregulation in Long-Standing Type 1 Diabetes with Hypoglycemia Unawareness. [PDF]

Diabetes Technol Ther, 2023
Objective: Automated insulin delivery (AID) may benefit individuals with long-standing type 1 diabetes where frequent exposure to hypoglycemia impairs counterregulatory responses.
Flatt AJ, Peleckis AJ, Dalton-Bakes C, Nguyen HL, Ilany S, Matus A, Malone SK, Goel N, Jang S, Weimer J, Lee I, Rickels MR.   +11 more
europepmc   +2 more sources

The Antinarcolepsy Drug Modafinil Reverses Hypoglycemia Unawareness and Normalizes Glucose Sensing of Orexin Neurons in Male Mice. [PDF]

Diabetes, 2023
Perifornical hypothalamus (PFH) orexin glucose-inhibited (GI) neurons that facilitate arousal have been implicated in hypoglycemia awareness. Mice lacking orexin exhibit narcolepsy and orexin mediates the effect of the anti-narcolepsy drug, modafinil ...
Patel V, Sarkar P, Siegel DM, Teegala SB, Hirschberg PR, Wajid H, Itani O, Routh VH.   +7 more
europepmc   +2 more sources

0592 Hybrid Closed Loop Insulin Delivery Systems Reduce Perceived Hypoglycemia During Sleep in Adults With Long-Standing Type 1 Diabetes and Hypoglycemia Unawareness [PDF]

Sleep, 2022
Sleep-associated hypoglycemia is a major concern for individuals with type 1 diabetes (T1D). Hybrid closed loop insulin delivery systems with continuous glucose monitoring (HCL-CGM) may reduce the perceived frequency, severity, and impact of sleep ...
Austin Matus, Susan Kohl Malone, Anneliese J. Flatt, Amy J. Peleckis, Cornelia Dalton-Bakes, Michael R. Rickels, Namni Goel   +6 more
openalex   +2 more sources

422 Preclinical drug screen leads to clinical trial for treatment of hypoglycemia unawareness in type 1 diabetes mellitus [PDF]

Journal of Clinical and Translational Science
Objectives/Goals: People with insulin-treated diabetes face hypoglycemia risk due to imperfect insulin replacement and impaired counterregulation. We identified the dopamine antagonist, metoclopramide, as a potential treatment. Hypothesis: Treatment with
MICAH H. DEVORE, Ashley Iles, LILY A. SCHOEDER, MEGAN B. MUSIC, BANSI PATEL, ASHLEE R. MARKSBURY, MASON WOOTEN, Andrea M. Woodcox, Zachary Beckner, Erica Lyn Macon, Simon J. Fisher   +10 more
openalex   +2 more sources

Prevalence and Risk Factors of Hypoglycemia Unawareness Among Patients With Type 1 and Type 2 Diabetes Mellitus in Saudi Arabia: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Objective: Hypoglycemia unawareness (HU), also known as impaired awareness of hypoglycemia (IAH), is a significant complication of insulin therapy that increases the risk of severe neuroglycopenic events in patients with type 1 diabetes mellitus (T1DM ...
Almohammadi MA, Aloufi AM, Alharbi AM, Aljohani AF, Almohammadi OA, Almohammadi AA, Alharbi WH, Almutairi FA, Almohammadi AF, Alhuwayfi AS.   +9 more
europepmc   +2 more sources