Results 71 to 80 of about 79,496 (316)

Selective estrogen receptor modulators and aromatase inhibitors in the treatment of functional male hypogonadism

Endokrynologia Polska
Functional hypogonadism is a syndrome characterized by low testosterone levels and clinical features of hypogonadism without organic disease of the hypothalamus–pituitary–gonadal axis.
Jakub Wydra, Arnika Wydra, Piotr Kucharczyk, Grzegorz Kapuściński, Wojciech Zgliczyński, Michał Rabijewski   +5 more
doaj   +1 more source

Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype. [PDF]

, 2019
Kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Recent evidence indicates that kisspeptin is also important for body weight and metabolism, as whole-body Kiss1r KO mice, developed with gene trap technology, display obesity ...
Kauffman, Alexander S, Marooki, Nuha, Smith, Jeremy T, Tolson, Kristen P, Wolfe, Andrew   +4 more
core   +1 more source

Non-targeted LC-MS based metabolomics analysis of the urinary steroidal profile [PDF]

, 2017
The urinary steroidal fraction has been extensively explored as non-invasive alternative to monitor pathological conditions as well as to unveil the illicit intake of pseudo-endogenous anabolic steroids in sport.
Botrè, Francesco, de la Torre, Xavier, Palermo, Amelia, Zamboni, Nicola   +3 more
core   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Hypogonadism and associated factors among male Leprosy patients.

PLoS Neglected Tropical Diseases
BackgroundLeprosy affects various organs in addition to skin, eyes, and peripheral nerves. Testicular involvement in leprosy patients is common and causes disturbance in endocrine function of the testis and results in hypogonadism.
Nafyad Tolossa Urgie, Miftah Oumer Surur, Shimelis Nigussie, Beniam Worku Yigazu, Kidist Bobosha, Abebaye Aragaw, Getahun Shibru   +6 more
doaj   +1 more source

Association Between Type 2 Diabetes and Hypogonadism in India: An Observational Study

Indian Journal of Endocrinology and Metabolism
Introduction: Hypogonadism is a common comorbidity associated with several metabolic disorders including type 2 diabetes (T2D) that can remain undetected without proper screening.
Ambika G. Unnikrishnan, Banshi D. Saboo, Anirban Majumdar, Ravi K. Saraogi, Shanmuga Sundar, Shriraam Mahadevan, Anantharaman Ramakrishnan, Indraneel Basu, Deep Dutta, Arpan D. Bhattacharya, Prakadeesh Bharathi, Kalpesh Gawand   +11 more
doaj   +1 more source

Guidelines for the Diagnosis and Treatment of testosterone deficiency (hypogonadism) in male patients with diabetes mellitus

Ожирение и метаболизм, 2017
Hypogonadism in men, defined as a reduction in serum testosterone in combination with characteristic symptoms and/or signs (described in detail later), is common in diabetes mellitus (DM). These recommendations do not cover the whole range of pathologies
Ivan I. Dedov, Galina A. Mel'nichenko, Marina V. Shestakova, Roman V. Rozhivanov, Anna L. Terehova, Alexey V. Zilov, Daria O. Ladygina, Dmitriy G. Kurbatov   +7 more
doaj   +1 more source

Pancreas Cancer-Associated Weight Loss. [PDF]

, 2019
Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality.
Denlinger, Crystal S, Hendifar, Andrew E, Matrisian, Lynn M, Petzel, Maria QB, Picozzi, Vincent J, Precision Promise Consortium, Rahib, Lola, Zimmers, Teresa A   +7 more
core  

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Rare Chromosomal Variants in Males with Hypogonadism: A Case Series From Tertiary Hospital in India

National Board of Examinations Journal of Medical Sciences
Male hypogonadism refers to decrease in testosterone levels due to diminished activity of testes. Hypogonadism will result in infertility, absent or poor secondary sexual characteristics and abnormal genitalia.
Anjali Shastry
doaj   +1 more source