Results 71 to 80 of about 3,173,890 (267)

Emerging therapies in the medical management of thyroid eye disease

Frontiers in Ophthalmology, 2023
IntroductionThyroid eye disease (TED) is an immune-mediated disorder associated with a heterogenous array of manifestations that may unfavorably impact vision and quality of life.
Alisha Kamboj, Andrew R. Harrison, Andrew R. Harrison, Ali Mokhtarzadeh   +3 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes [PDF]

, 2006
Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
A Augarten, A Linden, A Madej, A Trifilieff, AA Ionescu, AE Lovett-Racke, AP Sampson, B Staels, BM Forman, C Andersson, C Hubeau, C Hubeau, DC Jones, E Dagli, F Akbiyik, F McAllister, G Chinetti, H Pall, I Inoue, J Carlstedt-Duke, JD Dignam, JD Tugwood, JH Parmentier, JL Su, JM Shipley, JP Despres, JT Zakrzewski, K Balough, K Beier, KA Kreuzer, LS Nixon, M Ollero, M Roulet, MA Birrell, ME Poynter, N Marx, N Marx, P Delerive, P Greally, P Reineck, PM Farrell, PR Devchand, RB Moss, RB Moss, RB Moss, RU Sorensen, SD Freedman, SM Loitsch, SW Chung, TA Waldmann, TP Dean, TZ Khan, W Wahli, Z Israelian-Konaraki   +53 more
core   +4 more sources

Incidence and Risk Factors of Peri‐Implantitis Over Time—A Prospective Cohort Study

Journal of Periodontal Research, EarlyView.
Identifying true risk factors requires a longitudinal evaluation to verify the temporality criterion. This study identified periodontitis (stage and grade), lifestyle behaviours (smoking and sleep duration), implant location, and prosthetic factors (restoration type and margin location) as risk factors for peri‐implantitis.
Mario Romandini, Cristina Lima, Diogo Banaco, Rita Azevedo, Mariano Sanz   +4 more
wiley   +1 more source

Inhibition of palmitoyl CoA deacylase by chlorophenoxyisobutyrate and betabenzalbutyrate

Journal of Lipid Research, 1973
Palmitoyl CoA deacylase activity was measured in preparations of rat liver microsomes. Two hypolipidemic agents, chlorophenoxyisobutyrate and betabenzalbutyrate caused inhibition of palmitoyl CoA deacylase in vitro.
Robert G. Lamb, Patsy M. Hill, Harold J. Fallon   +2 more
doaj  

Atherosclerosis: Process, indicators, risk factors and new hopes [PDF]

, 2014
Background: Atherosclerosis is the major cause of morbidities and mortalities worldwide. In this study we aimed to review the mechanism of atherosclerosis and its risk factors, focusing on new findings in atherosclerosis markers and its risk factors ...
Baradaran, A., Doudi, M., Nasri, H., Rafieian-Kopaei, M., Setorki, M.   +4 more
core  

Burning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective

Oral Diseases, EarlyView.
ABSTRACT Objective To investigate the relationship between biological, psychological, and social factors underlying Burning Mouth Syndrome (BMS). Subjects and Methods A case (n = 40) and control (n = 42) study containing 80 variables was examined using two network models based on regularized partial correlations (n = 82).
Oscar Gabriel Castaño‐Joaqui, Laura Jiménez Ortega, Rocío Cerero Lapiedra, Adelaida África Domínguez Gordillo   +3 more
wiley   +1 more source

Outpatient Utilization Patterns of the Six Main ATC Drug Groups in Republic of Croatia, City of Zagreb, and Croatia Counties in 2004 [PDF]

, 2009
The aim of the study was to determine drug utilization according to Croatian counties, and to identify the causes of the possible between-county utilization variation.
Danijela Štimac, Ivan Vukušić, Josip Čulig, Mila Bucalić, Siniša Tomić, Zvonimir Šostar   +5 more
core   +1 more source

Hydroxytyrosol nicotinate, a new multifunctional hypolipidemic and hypoglycemic agent

Biomedicine & Pharmacotherapy, 2018
Hydroxytyrosol (HT) is a natural polyphenol antioxidant that exists in olive oil. In the study of multifunctional hypolipidemic of nicotinic derivatives, we found that hydroxytyrosol nicotinate (HT-N) incorporation of niacin with HT displayed ?-glucosidase inhibitory activities in vitro, such as yeast ?-glucosidase (IC50?=?117.72??M) and rat intestinal
Qiu-Tang Wang, Yuqiong Gao, Lu Wenfang, Xu Yanhong, Na Li, Li-Hua Shao, Yuan-Yuan Lin, Xie Yundong, Yiping Li, Zizhang Chen, Guangde Yang, Liying Guo, Xiaoli Bian   +12 more
openaire   +3 more sources

Impact of Drug–Drug Interactions on Clinical Outcomes in Metastatic Melanoma Patients Treated With Combined BRAF/MEK Inhibitors: A Real‐World Study

Pigment Cell &Melanoma Research, Volume 38, Issue 4, July 2025.
ABSTRACT The unique pharmacokinetics of BRAF and MEK inhibitors make patients vulnerable to drug–drug interactions (DDIs), which may compromise treatment efficacy in metastatic melanoma. This study evaluates the impact of DDIs on clinical outcomes in patients with metastatic melanoma treated with BRAF/MEK inhibitors.
Silvia Mezi, Andrea Botticelli, Giulia Pomati, Simone Scagnoli, Giulia Fiscon, Federica de Galitiis, Francesca Romana di Pietro, Sofia Verkhovskaia, Sasan Amirhassankhani, Giovanna Gentile, Maurizio Simmaco, Bjoern Gohlke, Robert Preissner, Daniele Santini, Paolo Marchetti   +14 more
wiley   +1 more source

PCSK9 Inhibitors: Clinical Relevance, Molecular Mechanisms, and Safety in Clinical Practice

Arquivos Brasileiros de Cardiologia, 2019
Coronary artery disease (CAD) is one of the leading causes of mortality. High circulating levels of low-density lipoprotein (LDL) in the blood are associated with cardiovascular mortality, whether through an etiological role or through its association ...
Filipe Ferrari, Ricardo Stein, Marcelo Trotte Motta, Emilio Hideyuki Moriguchi   +3 more
doaj   +1 more source