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What Is the Hypoplastic Left Heart Syndrome? [PDF]
Journal of Cardiovascular Development and Disease, 2023 As yet, there is no agreed definition for the so-called “hypoplastic left heart syndrome”. Even its origin remains contentious. Noonan and Nadas, who as far as we can establish first grouped together patients as belonging to a “syndrome” in 1958 ...
Robert H. Anderson +2 more
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Hypoplastic left heart syndrome [PDF]
Orphanet Journal of Rare Diseases, 2007 Hypoplastic left heart syndrome(HLHS) refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left
Thiagarajan Ravi, Connor Jean
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Hypoplastic left heart syndrome [PDF]
BMJ, 1997 Hypoplastic left heart syndrome is not an uncommon condition and accounts for about 10% of critical congenital heart disease in infants. Each year in Britain about 200 children will be born with this condition, which, unlike some other congenital cardiac lesions, usually occurs without serious associated non-cardiac malformations.
Sophie O’Kelly, Edward L. Bove
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What Is the Hypoplastic Left Heart Syndrome? [PDF]
World J Pediatr Congenit Heart Surg, 2023 As yet, there is no agreed definition for the so-called “hypoplastic left heart syndrome”. Even its origin remains contentious. Noonan and Nadas, who as far as we can establish first grouped together patients as belonging to a “syndrome” in 1958, suggested that Lev had named the entity.
Anderson RH, Spicer DE, Crucean A.
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Hypoplastic Left Heart Syndrome: A Case Report [PDF]
Journal of Nepal Medical Association, 2023 Hypoplastic left heart syndrome is a rare critical congenital heart defect constituting a prevalence of 1/3,500 to 1/12,500 live births in which there is obstructions to the blood flow within the left heart.
Sunil Raja Manandhar +4 more
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Hypoplastic left heart syndrome: a review [PDF]
Acta Medica Lituanica, 2016 Background. Hypoplastic left heart syndrome (HLHS) is an etiologically multifactorial congenital heart disease affecting one in 5,000 newborns. Thirty years ago there were no treatment options for this pathology and the natural course of the disease ...
Roberts Gobergs +2 more
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Nature Communications, 2022 The developmental mechanisms responsible for the structural defects observed in hypoplastic left heart syndrome remain controversial. Using rbfox-deficient zebrafish, the authors implicate impaired cardiac function as a primary driver of disease.
Mengmeng Huang +10 more
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Hypoplastic left heart syndrome with mitral regurgitation: a new marker of poor fetal outcome [PDF]
Journal of UltrasonographyHypoplastic left heart syndrome is a severe congenital heart defect that may be accompanied by tricuspid and mitral valve regurgitation. The aim of this paper is to identify a new ultrasound marker for evaluating the outcomes of fetuses with hypoplastic ...
Witkowski Sławomir +2 more
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Autologous umbilical cord blood mononuclear cell therapy for hypoplastic left heart syndrome: a nonrandomized control trial of the efficacy and safety of intramyocardial injections [PDF]
Stem Cell Research & TherapyBackground Preliminary phase I clinical trial results revealed that autologous umbilical cord blood-derived mononuclear cells (UCB-MNCs) preserved right ventricular cardiac function.
Carlos Gallego-Navarro +10 more
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First report of hypoplastic left heart syndrome in 3p- syndrome and review of candidate genes [PDF]
Revista Paulista de PediatriaObjective: 3p deletion syndrome is a rare monosomal disease that encompasses deletions throughout the short arm of chromosome 3. It is often in the distal region (3p25-pter), but variations in breakpoints and a complex clinical manifestation exist, with ...
Ana Kalise Böttcher +7 more
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