Results 251 to 260 of about 130,466 (307)

The hypothalamic-pituitary-adrenal axis

Clinics in Endocrinology and Metabolism, 1983
Anterior pituitary corticotrophin cells secrete ACTH as part of a larger precursor molecule, pro-opiomelanocortin. Post-translational cleavage of this precursor yields three major peptides: ACTH, beta-LPH and N-POMC. Experiments both in vivo and in vitro suggest that N-POMC may act as a prohormone amplifier for ACTH-induced adrenal steroidogenesis and ...
C M, Feek, D J, Marante, C R, Edwards
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Hypothalamic–pituitary–adrenal axis

2018
Increased adrenocortical secretion of hormones, primarily cortisol in depression, is one of the most consistent findings in neuropsychiatry. The maintenance of the internal homeostatic state of an individual is facilitated by the ability to circulate glucocorticoids to exert negative feedback on the secretion of hypothalamic–pituitary–adrenal (HPA ...
Allan H. Young, Mario F. Juruena
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The Immune-Hypothalamic-Pituitary-Adrenal Axis*

Endocrine Reviews, 1989
IN VERTEBRATES, four major systems of intercellular communication exist: the neural, the endocrine, the neuroendocrine, and the immune system. For many years evidence has accumulated linking the neural, the endocrine, and the neuroendocrine systems, but the immune system was often viewed as essentially autonomous.
A, Bateman, A, Singh, T, Kral, S, Solomon   +3 more
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Hypothalamic–pituitary–adrenal axis and stress

2020
Stress is associated with the onset of several stress-related mental disorders that occur more frequently in women than in men, such as major depression or posttraumatic stress disorder (PTSD). The hypothalamic-pituitary-adrenal (HPA) axis is the major component of the neuroendocrine network responding to internal and external challenges.
Carolin, Leistner, Andreas, Menke
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Hypothalamic-pituitary-adrenal-axis hyperactivity in bulimia

Psychiatry Research, 1983
Hyperactivity of the hypothalamic-pituitary-adrenal axis, demonstrated by nonsuppression of plasma cortisol in the dexamethasone suppression test (DST), has been found in about 50% of patients with major depression. We administered the DST to 47 patients with bulimia and to 22 age- and sex-matched normal controls.
J I, Hudson, H G, Pope, J M, Jonas, P S, Laffer, M S, Hudson, J C, Melby   +5 more
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Hypothalamic-pituitary-adrenal axis interaction with prostaglandins

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1990
1. The major PGE2 plasma metabolite, 15-keto-13, 14-dihydro-PGE (PGEM) was measured during metyrapone, dexamethasone and ACTH tests in order to elucidate if plasma PGE was affected by short term changes of the hypothalamic-pituitary adrenal axis function in man. 2. Plasma PGEM, serum cortisol and serum 11-deoxycortisol were determined by RIA.
M, Thorén, C, Stenfors, B, Apéria, A A, Mathé   +3 more
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Cytokines and the hypothalamic-pituitary-adrenal axis

The Journal of Steroid Biochemistry and Molecular Biology, 1990
After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit.
A R, Hermus, C G, Sweep
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The Hypothalamic‐Pituitary‐Adrenal Axis in Alcoholics

Alcoholism: Clinical and Experimental Research, 1983
The hypothalamic‐pituitary‐adrenal axis of a group of patients suffering from alcoholism was studied by determining their plasma corticosteroid levels and urinary‐free cortisol excretion before and after administration of 2 mg of dexamethasone. The patients were recently abstinent from alcohol and were found to be in a hypersecretory state.
J R, de La Fuente, A H, Rosenbaum, R M, Morse, R G, Niven, C F, Abboud, N S, Jiang, A F, Schatzberg   +6 more
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Hypothalamic-Pituitary-Adrenal Axis in Rheumatoid Arthritis

Rheumatic Disease Clinics of North America, 2010
The controlled data accumulated so far support only subtle alterations in HPA axis function in RA, mainly at the adrenal level, and particularly in a subset of premenopausal-onset women. Such interpretation is supported by consistent findings of lower levels of adrenal androgens, particularly DHEAS, in premenopausal-onset RA patients.
Richard, Imrich, Jozef, Rovenský
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The Hypothalamic‐Pituitary‐Adrenal Axis in Autoimmunity

Annals of the New York Academy of Sciences, 1997
We have characterized the activation of the HPA axis in the chronic inflammatory stress model of adjuvant-induced arthritis. Alteration in the hypothalamic control mechanism, where CRF is no longer the major corticotrophin-releasing factor, has been noted in a number of other immune-mediated disease models, including experimental allergic ...
M S, Harbuz, G L, Conde, O, Marti, S L, Lightman, D S, Jessop   +4 more
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