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Hypothalamic–pituitary–adrenal axis
2018Increased adrenocortical secretion of hormones, primarily cortisol in depression, is one of the most consistent findings in neuropsychiatry. The maintenance of the internal homeostatic state of an individual is facilitated by the ability to circulate glucocorticoids to exert negative feedback on the secretion of hypothalamic–pituitary–adrenal (HPA ...
Allan H. Young, Mario F. Juruena
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The hypothalamic–pituitary–adrenal axis in critical illness
Reviews in Endocrine and Metabolic Disorders, 2007Hypothalamic-pituitary-adrenal (HPA) axis function is crucial to maintain and restore homeostasis. The HPA axis does not function in isolation. Rather, the HPA axis modulates and reacts to signals from endocrine, neural, and immune systems. Cortisol is the major glucocorticoid secreted by the human adrenal cortex.
Shekhar, Venkataraman +3 more
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The hypothalamic–pituitary–adrenal axis in asthmatic children
Trends in Endocrinology & Metabolism, 2008Reduced responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis in patients with various chronic allergic inflammatory disorders and a blunted HPA axis response of poorly controlled asthmatics before long-term treatment with inhaled corticosteroids (ICS) have been reported. It seems that pro- and anti-inflammatory cytokines might be involved in
Kostas N, Priftis +3 more
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Hypothalamic-pituitary-adrenal axis and immune system.
Acta neurologica, 1994Complex and bidirectional relationships operate between the hypothalamic-pituitary-adrenal (HPA) axis and the immune system (IS) and either in vivo or in vitro evidence supports a physiological role of the HPA axis-IS network. A part of the well-known pharmacological effects of glucocorticoid hormones (GC) as immunodepressive agents, the direct effects
SAVASTANO, SILVIA +7 more
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Effect of sound on the hypothalamic-pituitary-adrenal axis
American Journal of Physiology-Legacy Content, 1963In the rat, the stress of exposure to continuous, high intensity sound (130 db, 220 cycles/sec) evoked a pattern of adrenocortical response consisting of an initial, immediate high rate of hormone secretion (determined in adrenal venous blood by chromatographic techniques), a subsequent period of depression of corticosterone output to normal or ...
R I, Henkin, K M, Knigge
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Hypothalamic-pituitary-adrenal axis interaction with prostaglandins
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19901. The major PGE2 plasma metabolite, 15-keto-13, 14-dihydro-PGE (PGEM) was measured during metyrapone, dexamethasone and ACTH tests in order to elucidate if plasma PGE was affected by short term changes of the hypothalamic-pituitary adrenal axis function in man. 2. Plasma PGEM, serum cortisol and serum 11-deoxycortisol were determined by RIA.
M, Thorén +3 more
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Effects of vindesine on hypothalamic-pituitary-adrenal axis
Toxicology Letters, 1995Vindesine, a cell-cycle-specific agent currently employed in the treatment of some neoplasias, was able to produce a remarkable dose-dependent adrenocortical activation, but it was unable to increase plasma corticosterone in hypophysectomized rats in vivo.
BRUNETTI, Luigi +3 more
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Leptin and the Regulation of the Hypothalamic–Pituitary–Adrenal Axis
2007Leptin, the product of the obesity gene (ob) predominantly secreted from adipocytes, plays a major role in the negative control of feeding and acts via a specific receptor (Ob-R), six isoforms of which are known at present. Evidence has been accumulated that leptin, like other peptides involved in the central regulation of food intake, controls the ...
Malendowicz LK +4 more
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Suicide and the hypothalamic-pituitary-adrenal axis
The Lancet, 2005Elizabeth A, Young, William, Coryell
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Human Placenta and the Hypothalamic-Pituitary-Adrenal Axis
1988Maternal plasma bound and free cortisol rises during pregnancy, while maternal plasma IR-ACTH is initially low but soon rises inspite of the further increase of plasma free cortisol. This rise of plasma ACTH during pregnancy, can not be attributed to changes of plasma levels of estrogens or progesterone.
A N, Margioris +3 more
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