Results 101 to 110 of about 151,312 (311)

Salubrinal abrogates palmitate-induced leptin resistance and endoplasmic reticulum stress via nuclear factor kappa-light-chain-enhancer of activated B cell pathway in mHypoE-44 hypothalamic neurons

Diabetes, Metabolic Syndrome and Obesity, 2018
Min Zhang,1 Xiaohong Jiang,2 Meidi Qu,1 Hongliu Gu,1 Qi Sha,1 Fei Hua2 1Department of Clinical Nutrition, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, China; 2Department of Endocrinology, The Third Affiliated Hospital ...
Zhang M, Jiang X, Qu M, Gu H, Sha Q, Hua F   +5 more
doaj  

Construction of an intranasal drug delivery system with hypothalamus‐targeting nanoparticles

SusMat
Dysfunction of the hypothalamus is associated with endocrine imbalances, growth abnormalities, and reproductive disorders. However, there is a lack of targeted treatment strategies focused on the hypothalamus.
Qianru Rao, Yujie Xu, Xiaorong Wang, Hang Luo, Haoqi Li, Jingyuan Xiong, Huile Gao, Guo Cheng   +7 more
doaj   +1 more source

Steady-state energy balance in animal models of obesity and weight loss [PDF]

, 2016
Supported by European Union Seventh Framework Programme (FP7/2007-2013, n°266408 (Full4Health)), the Joint Programme of the Medical Faculty of Norwegian University of Science and Technology (NTNU) and St. Olav’s University Hospital, the Liaison Committee
Barrett, Perry, Cassie, Nikki, Chen, Duan, Johannessen, Helene, Kulseng, Bård, Olsen, Magnus Kringstad, Takeuchi, Koji, Zhao, Chun-Mei   +7 more
core   +2 more sources

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Animal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu, Yafei Yang, Chunxi Liu, Danting Wen, Tingyu Zhao, Ping Xie, Jing Xiao   +6 more
wiley   +1 more source

Sudden onset of sleep caused by hypothalamic infarction: a case report

BMC Neurology, 2019
Background Hypothalamic lesions, such as tumors and demyelinating diseases, reportedly cause abnormal sleepiness. However, stroke involving the hypothalamus has rarely been described.
Takeo Matsubara, Keisuke Suzuki, Akiko Kawasaki, Masayuki Miyamoto, Madoka Okamura, Takashi Kanbayashi, Hidehiro Takekawa, Toshiki Nakamura, Yuji Watanabe, Masanori Matsubara, Koichi Hirata   +10 more
doaj   +1 more source

Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Animal Models and Experimental Medicine, EarlyView.
Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee, Yoongeun Kim, Hyungjun Kim, Dae‐Hyun Hahm   +3 more
wiley   +1 more source

Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice

Molecular Metabolism
Background: Chronic high-fat diet (HFD) feeding triggers hypothalamic inflammation and systemic metabolic dysfunction associated with endoplasmic reticulum (ER) stress.
L. Stilgenbauer, Q. Chen, D. Pungi, N. James, H. Jayarathne, L. Koshko, S. Scofield, K. Zhang, M. Sadagurski   +8 more
doaj   +1 more source

Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism

Frontiers in Molecular Neuroscience, 2018
Neurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS)
Pauline Vercruysse, Pauline Vercruysse, Pauline Vercruysse, Didier Vieau, David Blum, Åsa Petersén, Luc Dupuis, Luc Dupuis   +7 more
doaj   +1 more source

The Iowa Perinatal Letter, April-May-June 2008, Vol. 29, no. 2 [PDF]

, 2008
This newsletter from The Department of Public Health about perinatal health care and ...

core