Results 111 to 120 of about 151,312 (311)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Aging changes the expression of adenosine receptors, insulin-like growth factor 1 (IGF1), and hypoxia-inducible factor 1α (HIF1α) in hypothalamic astrocyte cultures

Aging Brain
The aging process induces neurochemical alterations in different brain regions, including hypothalamus. This pivotal area of the central nervous system (CNS) is crucial for detection and integration of nutritional and hormonal signals from the periphery ...
Camila Leite Santos, Larissa Daniele Bobermin, André Quincozes-Santos   +2 more
doaj   +1 more source

Hypothalamic disease in craniopharyngioma patients.

, 2019
Craniopharyngioma (CP) patients suffer from high rates of morbidity and mortality. The aim of this study was to describe hypothalamic morbidityand establish the standardised mortality ratio for CP patients attendingthe national neurosurgical unit in Ireland; to investigate abnormalities ofthirst, sleep disorders and somnolence, glucose tolerance and ...
openaire   +1 more source

Functional Segregation of Epileptogenicity within the Human Amygdala

Annals of Neurology, EarlyView.
Objective In temporal lobe epilepsy (TLE), the amygdala in the epileptogenic network is underestimated compared to other regions such as the hippocampus. Recent advances in anatomical neuroimaging and stereoelectroencephalography (SEEG) signal analyses could help better understand the involvement of the different amygdala nuclei in the genesis of ...
Odile Feys, Julia Makhalova, Samuel Medina Villalon, Maria Fratello, Hugo Dary, Stanislas Lagarde, Francesca Pizzo, Agnès Trébuchon, Maxime Guye, Jean‐Philippe Ranjeva, Romain Carron, Didier Scavarda, Christian‐George Bénar, Bernard Giusiano, Fabrice Bartolomei   +14 more
wiley   +1 more source

Sex differences in regional hypothalamic volume and resting-state connectivity patterns: An ultra-high field functional magnetic resonance imaging investigation

NeuroImage
The hypothalamus is a key homeostatic regulatory region which contains nuclei and subregions known to mediate a range of body functions. Numerous studies have revealed that the hypothalamus is critical in coordinating sexual dimorphism in neuroendocrine ...
Yun A. Huang, Rebecca V Robertson, Noemi Meylakh, Lewis S Crawford, James WM Kang, Paul M Macey, Vaughan G Macefield, Paul J Austin, Kevin A Keay, Luke A Henderson   +9 more
doaj   +1 more source

Early and late endocrine effects in pediatric central nervous system diseases

Journal of Pediatric Rehabilitation Medicine, 2014
Endocrinopathies are frequently linked to central nervous system disease, both as early effects prior to the disease diagnosis and/or late effects after the disease has been treated.
Ivy R. Aslan, Clement C. Cheung
doaj   +1 more source

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

Angewandte Chemie International Edition, EarlyView.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Pathogenic hypothalamic extracellular matrix promotes metabolic disease

Nature
Metabolic diseases such as obesity and type 2 diabetes are marked by insulin resistance1,2. Cells within the arcuate nucleus of the hypothalamus (ARC), which are crucial for regulating metabolism, become insulin resistant during the progression of metabolic disease3-8, but these mechanisms are not fully understood.
Cait A. Beddows, Feiyue Shi, Anna L. Horton, Sagar Dalal, Ping Zhang, Chang-Chun Ling, V. Wee Yong, Kim Loh, Ellie Cho, Chris Karagiannis, Adam J. Rose, Magdalene K. Montgomery, Paul Gregorevic, Matthew J. Watt, Nicolle H. Packer, Benjamin L. Parker, Robyn M. Brown, Edward S. X. Moh, Garron T. Dodd   +18 more
openaire   +3 more sources

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Effect of Cyclic Heat Exposure on the Growth Performance and Metabolism of Broilers Fed Palm Kernel Meal

Animal Research and One Health, EarlyView.
The aim of our study is to evaluate the interaction between HS and the incorporation of PKM in broiler chicken diets, as well as its effect on growth performance and metabolism. Based on the results obtained, PKM supplementation failed to mitigate the adverse effects of heat stress in broiler chickens. ABSTRACT The aim of this study was to evaluate the
Ahmed Mijiyawa, Elham Ghashghaei, Okasha Hamada, Huimin Wang, Lijing Sun, Yendouhamtchié Nadiedjoa, Dan Wang, Zhengkai Yue, Clarice Maa Maa Temhoul, Maxwell Ansong Okai, Muhammad Faisal Riaz, Felix Kwame Amevor, Wéré Pitala, Hai Lin   +13 more
wiley   +1 more source