Results 251 to 260 of about 151,312 (311)
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Investigation of hypothalamic-pituitary disease
Clinics in Endocrinology and Metabolism, 1983It can be readily appreciated from the preceding discussion that many endocrine and non-endocrine tests are available for the evaluation of patients with suspected hypothalamic-pituitary disease. The endocrine evaluation of these subjects should be tailored according to the type and extent of pathology suspected (see Tables 2 and 3).
R P, Lamberton, I M, Jackson
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Hypothalamic pathology in Alzheimer's disease
Neuroscience Letters, 1987The hypothalamus was examined in 3 cases of Alzheimer's disease and 3 control brains, using combined acetylcholinesterase (AChE) and thioflavin-S staining. Neurons undergoing neurofibrillary degeneration were restricted to 3 AChE-positive cell populations (lateral tuberal, lateral posterior and tuberomammillary) that have been found in the rat and ...
C B, Saper, D C, German
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Hypothalamic Glucose Sensing and Glycaemic Disease
Current Diabetes Reviews, 2011An adequate supply of nutrients is obligatory for life. Glucose is one of the main circulating substrates fuelling the mammalian body, particularly brain, and is normally maintained within a narrow range to ensure health. Given the challenge of maintaining glucose homeostasis, mammals have evolved specialized sensors for monitoring changes in glucose ...
Mayowa A, Osundiji, Mark L, Evans
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Hypothalamic–endocrine aspects in Huntington's disease
European Journal of Neuroscience, 2006AbstractHuntington's disease (HD) is a hereditary and fatal disorder caused by an expanded CAG triplet repeat in the HD gene, resulting in a mutant form of the protein huntingtin. Wild‐type and mutant huntingtin are expressed in most tissues of the body but the normal function of huntingtin is not fully known. In HD, the neuropathology is characterized
Asa, Petersén, Maria, Björkqvist
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Hypothalamic Releasing Factors and Parkinson Disease
Archives of Neurology, 1974Therapeutic trials of intravenously infused thyrotrophin-releasing hormone or melanocyte-stimulating hormone releaseinhibiting factor were conducted in patients with idiopathic parkinsonism. Thyrotrophin-releasing hormone had no consistent effect on extrapyramidal function in five otherwise untreated patients, nor did it significantly modify the ...
T N, Chase +3 more
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Functional Hypothalamic Amenorrhea and Preclinical Cardiovascular Disease
The Journal of Clinical Endocrinology & Metabolism, 2023Abstract Context Endothelial dysfunction is a preclinical cardiovascular disease (CVD) marker. Due to various neuroendocrine aberrations, functional hypothalamic amenorrhea (FHA) may be a sex-specific risk factor for CVD in young women. Objective
Chrisandra L Shufelt +8 more
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Hypothalamic-pituitary function in Cushing’s disease
Journal of Endocrinological Investigation, 1979Hypothalamic pituitary function was evaluated in seven patients with Cushing's disease. In all subjects there was an absence of GH elevation following hypoglycemia. Three patients demonstrated basal hyperprolactinemia. Six had an intact PRL rise following TRH.
D, Le Roith +3 more
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Methopyrapone Tests in Hypothalamic-Pituitary Disease
The Journal of Clinical Endocrinology & Metabolism, 1964This study was designed to investigate the efficacy of the methopyrapone test in disclosing possible abnormalities in ACTH release in patients with central nervous system or pituitary disease who exhibited little or no endocrine impairment. Methopyrapone tests were carried out in 10 patients with primarily hypothalamic disease, and in 14 patients with ...
D T, KRIEGER, H, KOLODNY, H P, KRIEGER
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Diseases of hypothalamic releasing factors
Disease-a-Month, 1976Summary One can clearly see that clinical neuroendocrinology has grown remarkably over the past several years and that it is in the midst of constant development and change. The advances in the basic sciences are rapidly being utilized by clinical investigators and many neuroendocrine principles first espoused in laboratory animals are being ...
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Hypothalamic Peptides in Human Brain Diseases
Trends in Endocrinology & Metabolism, 1999The human hypothalamus is subdivided into some 20 well-defined nuclei that have a multitude of specific functions from the time of birth to the moment we die. Hypothalamic nuclei show structural and functional differences not only in relation to classic neuroendocrine disorders, such as diabetes insipidus, climacteric flushes and Kallman's syndrome ...
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