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Neurologic manifestations of hypothalamic disease.
Progress in brain research, 1993The hypothalamus, in addition to regulating the anterior and posterior pituitary, controls water balance through thirst, regulates food ingestion and body temperature, influences consciousness, sleep, emotion and other behaviors. Much has been learned of these effects in human disease through the clinical manifestations that occur with hypothalamic ...
J B, Martin, P N, Riskind
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Hypothalamic Compensatory Mechanisms in Parkinson's Disease
International Journal of Neuroscience, 1989Parkinson's disease (PD) is associated with loss of dopaminergic neurons of the nigrostriatal bundle and to a lesser extent of the mesolimbic and hypothalamic dopaminergic systems. Frank symptoms of the disease usually emerge when at least 70-80% of striatal dopamine (DA) content have been reduced, raising the possibility that the preclinical phase of ...
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Clinical endocrinological approach to hypothalamic-pituitary disease
Journal of Neurosurgery, 1979✓ The authors review the present knowledge of the hypothalamic-pituitary endocrine axis. The physiology and pathophysiology are discussed along with outlines of standard approaches to diagnosis of disorders. An appendix of useful provocative tests is included.
C F, Abboud, E R, Laws
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Hypothalamic-Pituitary Disease
1987The pituitary gland arises from the conjunction of an evagination of the oral cavity (Rathke’s pouch) and a process of neural ectoderm growing down from the ventral portion (hypothalamic region) of the diencephalon. The former becomes the adenohypophysis (anterior pituitary) and the latter the neurohypophysis (posterior pituitary); by 10–12 weeks of ...
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Neurosurgical Aspects of Hypothalamic Disease
2020Lesions within the hypothalamus pose many difficulties for a neurosurgeon – the intricate anatomy and numerous critical structures surrounding it make the hypothalamus a difficult region of the brain to access. When considering neurosurgical management of hypothalamic lesions, there are a number of possible approaches dependent on the type of lesion ...
Ketan R. Bulsara +3 more
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Hypothalamic and Neuroendocrine Changes in Huntingtons Disease
Current Drug Targets, 2010Huntington's disease (HD) is neither a fatal hereditary neurodegenerative disorder without satisfactory treatments nor a cure. It is caused by a CAG repeat expansion in the huntingtin gene. The clinical symptoms involve motor-, cognitive- and psychiatric disturbances.
Sofia, Hult +3 more
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HYPOTHALAMIC DIGOXIN-MEDIATED MODEL FOR PARKINSON'S DISEASE
International Journal of Neuroscience, 2003The isoprenoid pathway produces four key metabolites important in cellular function--digoxin (endogenous membrane Na(+)-K+ ATPase inhibitor), dolichol (important in N-glycosylation of proteins), ubiquinone (free-radical scavenger), and cholesterol (component of cellular membranes).
Ravi Kumar, Kurup +1 more
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Hypothalamic Endocrinopathy in Hand-Schüller-Christian Disease
Annals of Internal Medicine, 1978Excerpt Hand-SchUller-Christian disease is characterized by infiltration of multiple organs by well-differentiated histiocytes.
J G, Rothman, P J, Snyder, R D, Utiger
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A22 Hypothalamic changes in Huntington's disease
Journal of Neurology, Neurosurgery & Psychiatry, 2010Background In recent years it has become increasingly clear that the hypothalamus might be affected in Huntington9s disease (HD), and that this may underlie many features in this disease. Research on the hypothalamus itself in HD patients, however, has so far been limited.
D van Wamelen +5 more
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Traumatic and Degenerative Hypothalamic Diseases
2020The hypothalamus, with its important homeostatic properties, can be associated with significant deleterious consequences when it is impacted either by traumatic brain injury, vascular insult, or neurodegenerative disease. Lesions affecting the hypothalamic-pituitary axis, following traumatic brain injury, can result in hypopituitarism with isolated ...
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