Results 41 to 50 of about 151,312 (311)

Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging

Frontiers in Neuroscience, 2023
IntroductionHypothalamic glucose-sensitive neural circuits, which regulate energy metabolism and can contribute to diseases such as obesity and type 2 diabetes, have been difficult to study in humans.
Jorge Manuel, Jorge Manuel, Eva Halbe, Eva Halbe, Ann Charlotte Ewald, Alex Hoff, Jens Jordan, Jens Jordan, Jens Tank, Karsten Heusser, Darius A. Gerlach   +10 more
doaj   +1 more source

Hormonal regulation of female reproduction [PDF]

, 2012
Reproduction is an event that requires the coordination of peripheral organs with the nervous system to ensure that the internal and external environments are optimal for successful procreation of the species.
Bentley, G. E., Cabrera Kreiker, Ricardo Jorge, Christensen, A., Micevych, P., Ortega, Hugo Hector, Perfito, N., Wu, T. J.   +6 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Hypothalamic GABAergic neurons: their roles in health and metabolic diseases

Frontiers in Endocrinology
Hypothalamic GABAergic neurons are important in regulating metabolic homeostasis and energy balance. Serving as critical integrators of catabolic and anabolic processes, these neurons orchestrate a broad spectrum of metabolic functions, including feeding,
Bingwei Wang, Bingwei Wang, Bingwei Wang, Yang Yu, Yang Yu, Yang Yu, Yang Yu, Juan Li, Yu Xiong, Xin Zhang, Xin Zhang, Xin Zhang, Xin Zhang, Ying Wan, Ruimao Zheng, Ruimao Zheng, Ruimao Zheng, Ruimao Zheng, Chunxiang Zhang, Chunxiang Zhang, Chunxiang Zhang, Chunxiang Zhang, Chunxiang Zhang   +22 more
doaj   +1 more source

Anorexia nervosa and reproduction: connecting brain to gonads [PDF]

, 2020
Anorexia nervosa (AN) is a psychiatric disorder that predominantly affects young women and is characterized by low caloric intake and a major dissatisfaction with one’s body image.
Ciobanu, Corina, Fica, Simona, Poterasu, Mihaela, Rowland, David L.   +3 more
core   +2 more sources

Aquaporin‐4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Narcolepsy type 1 (NT1) is caused by the loss of hypocretin‐1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin‐4 (AQP4 ...
Jonas Ranke, Petra Steinacker, Steffen Halbgebauer, Patrick Oeckl, Geert Mayer, Markus Otto   +5 more
wiley   +1 more source

In vitro examination of microglia-neuron crosstalk with BV2 cells, and primary cultures of glia and hypothalamic neurons

Heliyon, 2018
Microglia respond to environmental changes by releasing cytokines that beneficially or detrimentally affect surrounding cells in addition to functioning as the resident CNS macrophages.
Xinrong Tao, Na Li, Fei Liu, Yuting Hu, Jing Liu, Yong-Mei Zhang   +5 more
doaj   +1 more source

Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice

Cell Death Discovery, 2021
Necroptosis, a form of programmed cell death, accounts for many inflammations in a wide range of diseases. Diet-induced obesity is manifested by low-grade inflammation in the mediobasal hypothalamus (MBH), and microglia are implicated as critical ...
Xuan Li, You Cai, Jiao Luo, Jingyun Ding, Guojun Yao, Xiaohua Xiao, Yizhe Tang, Zhen Liang   +7 more
doaj   +1 more source

Critical roles of endogenous glucocorticoids for disease tolerance in malaria

, 2019
During malaria, the hypothalamic-pituitary-adrenal (HPA) axis is activated and glucocorticoid (GC) levels are increased, but their essential roles have been largely overlooked.
De Bosscher, Karolien, Opdenakker, Ghislain, Van den Steen, Philippe E., Vandermosten, Leen, Vanhorebeek, Ilse   +4 more
core   +1 more source

Pituitary-adrenal axis in Prader Willi syndrome [PDF]

, 2016
Purpose: Prader Willi syndrome (PWS) is a rare genetic condition that has concurrent endocrinological insufficiencies. The presence of growth hormone deficiency has been well documented, but adrenal insufficiency (AI) is not widely reported. A review was
Edgar, Olivia S., Lucas-Herald, Angela K., Shaikh, Mohamad Guftar   +2 more
core   +2 more sources