Results 151 to 160 of about 124,713 (209)
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Degradation of hypothalamic hormones
Naunyn-Schmiedebergs Archives of Pharmacology, 1977The enzymatic fragmentation of TRH (pyroGlu-His-Pro-NH2) by serum, hypothalamic and hypophyseal tissue was investigated. As primary cleavage product only His-Pro-NH2 was detected when TRH was incubated with serum while with the tissue preparations the formation of His-Pro-NH2, deamido-TRH and prolineamide could be detected as enzymatically formed ...
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Anti-Cancer Drugs, 1994
The discovery of hypothalamic hormones, especially LH-RH and somatostatin has led to practical clinical use of their analogs in the field of cancer treatment. Bombesin/GRP antagonists can be also considered for the development of new methods for treatment of various tumors.
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The discovery of hypothalamic hormones, especially LH-RH and somatostatin has led to practical clinical use of their analogs in the field of cancer treatment. Bombesin/GRP antagonists can be also considered for the development of new methods for treatment of various tumors.
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Hypothalamic effects of thyroid hormone
Molecular and Cellular Endocrinology, 2017Thyroid hormone (TH) is a key driver of metabolism in mammals. Plasma concentrations of TH are kept within a narrow range by negative feedback regulation in the hypothalamus-pituitary-thyroid (HPT) axis. Plasma TH concentrations are an important determinant of metabolic processes in liver and brown adipose tissue (BAT). In addition to endocrine effects
Zhang, Zhi +4 more
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HYPOTHALAMIC HORMONE INTERACTION IN ACROMEGALY
Clinical Endocrinology, 1975SUMMARYThe growth hormone response to the administration of the currently available synthetic hypothalamic hormones was assessed in eleven patients with acromegaly. Eight of them showed a positive GH response to thyrotrophin releasing hormone and three showed no response.
A, Gomez-Pan +7 more
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Growth hormone receptors in hypothalamic and extra-hypothalamic tissues
Journal of Molecular Endocrinology, 1990ABSTRACT Central GH receptors (GHR) have been identified in hypothalamic and extra-hypothalamic tissues of rabbit and chicken brains. Plasma membranes of the rabbit brain demonstrated specific saturable high-affinity, low-capacity binding sites for 125I-labelled GH.
R A, Fraser, D, Attardo, S, Harvey
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Hypothalamic releasing hormones
Trends in Pharmacological Sciences, 1981Abstract The adenohypophysis was once regarded as a ‘master gland' responsible for the control and integration of many aspects of endocrine function. However, 30 years ago it became evident from the ingenious studies of the late G. W. Harris that the secretory activity of the adenohypophysis is under the control of neurohumoral substances secreted by ...
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Hypothalamic hypophysiotropic hormones
1976In the last few years several hypothalamic peptides that regulate adenohypo- physial functions have been isolated, their primary structure determined and their synthesis achieved. The existence of these peptides had been predicted by a large body of conceptual reasoning and experimental evidence, and their availability in unlimited amounts by total ...
N. Fleischer, R. Guillemin
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Hypothalamic Hypophysiotropic Hormones
1975A large body of experimental evidence supports the key role played by hypothalamic neurosecretory cells in coordinating the activities of the central nervous and endocrine systems. The nonapeptides vasopressin and oxytocin, synthesized in nerve cell bodies of the supraoptic and paraventricular nuclei, travel by axoplasmic flow within tracts terminating
Wylie Vale, Catherine Rivier
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Growth hormone stimulates hypothalamic somatostatin
Life Sciences, 1979Abstract Hypothalamic somatostatin concentration is increased in normal rats treated with growth hormone. Somatostatin is reduced in the median eminence of hypophysectomized rats but restored to normal following growth hormone administration. These results suggest that growth hormone exerts a positive feedback effect on hypothalamic somatostatin ...
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