Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice
eLife, 2021 Hypersomnolence disorder (HD) is characterized by excessive sleep, which is a common sequela following stroke, infection, or tumorigenesis. HD is traditionally thought to be associated with lesions of wake-promoting nuclei.
Chang-Rui Chen +7 more
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Distinct Hypothalamic Paraventricular Nucleus Inputs to the Cingulate Cortex and Paraventricular Thalamic Nucleus Modulate Anxiety and Arousal [PDF]
Frontiers in Pharmacology, 2022 Insomnia and anxiety are two common clinical diseases that threaten people’s physical and mental health. Insomnia and anxiety may share some similar underlying neural circuit mechanisms in the brain.
Ying Liu +7 more
doaj +5 more sources
Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: role of the hypothalamic paraventricular nucleus. [PDF]
PLoS ONE, 2012 The mechanism of cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus (ARCN) was studied in urethane-anesthetized adult male Wistar rats.
Tetsuya Kawabe +2 more
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Curcumin mitigates the sleep-deprivation impacts on rat hypothalamic paraventricular nucleus [PDF]
IBRO Neuroscience Reports, 2023 Introduction: The paraventricular nucleus of the hypothalamus (PVH) is an important efferent system that relays the circadian rhythm of sleep and stress information to the periphery.
Mahboobeh Erfanizadeh +4 more
doaj +2 more sources
The microbiota shapes the development of the mouse hypothalamic paraventricular nucleus. [PDF]
Horm BehavMicrobes massively colonize the mammalian newborn at birth. We previously reported that the microbiota influences key neurodevelopmental events, e.g., when compared to their conventionally colonized (CC) counterparts, sterile newborn mice ("germ-free" or GF) show higher cell death in the hypothalamic paraventricular nucleus (PVN).
Milligan YC +6 more
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Effects of Nrf1 in Hypothalamic Paraventricular Nucleus on Regulating the Blood Pressure During Hypertension [PDF]
Frontiers in Neuroscience, 2021 The incidence rate and mortality of hypertension increase every year. Hypothalamic paraventricular nucleus (PVN) plays a critical role on the pathophysiology of hypertension.
Xiao-Jing Yu +9 more
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Neurogenic Hypotension and Bradycardia Modulated by Electroacupuncture in Hypothalamic Paraventricular Nucleus [PDF]
Frontiers in Neuroscience, 2022 Electroacupuncture (EA) stimulates somatic median afferents underlying P5-6 acupoints and modulates parasympathoexcitatory reflex responses through central processing in the brainstem.
Stephanie C. Tjen-A-Looi +6 more
doaj +2 more sources
Role of the hypothalamic paraventricular nucleus in anxiety disorders
Stress and Brain, 2022 The hypothalamic paraventricular nucleus (PVN) expresses multiple neuropeptides and plays an essential role in several physiological processes. Among the brain areas directly projecting to the PVN are deep brain structures closely related to instinctive ...
Chen Wu, Mario A. Zetter
doaj +2 more sources
Electrophysiological Effects of Ghrelin in the Hypothalamic Paraventricular Nucleus Neurons
Frontiers in Cellular Neuroscience, 2018 The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus.
Raoni C. dos-Santos +5 more
doaj +3 more sources
Oxytocinergic Cells of the Hypothalamic Paraventricular Nucleus Are Involved in Food Entrainment. [PDF]
Front Neurosci, 2020 When food is presented at a specific time of day subjects develop intense locomotor behavior before food presentation, termed food anticipatory activity (FAA). Metabolic and hormonal parameters, as well as neural structures also shift their rhythm according to mealtime. Food-entrained activity rhythms are thought to be driven by a distributed system of
Caba M +4 more
europepmc +4 more sources