Results 1 to 10 of about 406,905 (221)

Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice [PDF]

eLife, 2021
Hypersomnolence disorder (HD) is characterized by excessive sleep, which is a common sequela following stroke, infection, or tumorigenesis. HD is traditionally thought to be associated with lesions of wake-promoting nuclei.
Chang-Rui Chen, Yu-Heng Zhong, Shan Jiang, Wei Xu, Lei Xiao, Zan Wang, Wei-Min Qu, Zhi-Li Huang   +7 more
doaj   +4 more sources

Synaptic output from suprachiasmatic nucleus cholecystokinin neurons regulates locomotor rhythmicity [PDF]

Frontiers in Neuroscience
BackgroundThe mammalian suprachiasmatic nucleus (SCN) serves as the master circadian pacemaker, which coordinates daily behavioral and physiological rhythms through functionally diverse neuronal subtypes. Cholecystokinin (CCK) is expressed in a subset of
Wanli Chen, Wanli Chen, Wanli Chen, Wanli Chen, Zhixiong Ma, Zhixiong Ma, Zhixiong Ma, Xiaoqing Hao, Xiaoqing Hao, Xiaoqing Hao, Shikang Guan, Shikang Guan, Shikang Guan, Xin Diao, Xin Diao, Xin Diao, Yuehong Huang, Yuehong Huang, Yuehong Huang, Yuehong Huang, Ruogu Liu, Ruogu Liu, Ruogu Liu, Ruogu Liu, Zhengran Li, Zhengran Li, Zhengran Li, Zhengran Li, Bingbing Xue, Bingbing Xue, Bingbing Xue, Tongfei A. Wang, Tongfei A. Wang, Tongfei A. Wang, Tongfei A. Wang   +34 more
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Distinct Hypothalamic Paraventricular Nucleus Inputs to the Cingulate Cortex and Paraventricular Thalamic Nucleus Modulate Anxiety and Arousal [PDF]

Frontiers in Pharmacology, 2022
Insomnia and anxiety are two common clinical diseases that threaten people’s physical and mental health. Insomnia and anxiety may share some similar underlying neural circuit mechanisms in the brain.
Ying Liu, Bo Rao, Shuang Li, Ning Zheng, Jie Wang, Linlin Bi, Linlin Bi, Haibo Xu   +7 more
doaj   +3 more sources

A hypothalamic circuit links high-fat diet exposure to anxiety-like behavior and anxiety-associated hyperphagia [PDF]

Nature Communications
Obesity and anxiety disorders are frequently comorbid, yet the neural circuit mechanisms linking metabolic and affective states remain incompletely understood.
Peng Wang, Jun Li, Xin Cheng, Wei Chen, Zhengyu Li, Zheng Fang, Dijia Wang, Bin Mei, Hu Liu, Shaohua Hu, Zhilai Yang, Jiqian Zhang, Gaolin Qiu, Xin Qing, Xuesheng Liu   +14 more
doaj   +2 more sources

Hypothalamic c-Fos expression changes during late chicken embryonic development and increases following experimental stimulation [PDF]

Scientific Reports
The timing of functional hypothalamic responsiveness during embryogenesis remains incompletely defined. We examined hypothalamic activation in chicken embryos from embryonic day (ED) 12–17 following experimental stimulation consisting of a localized foot
Leonhard Kowalczyk, Tobias Kowalczyk, Yile Huang, Maik Hintze, Longfei Cheng, Bernd  Hilgers, Stefanie Kuerten, Qin Pu, Inga Tiemann, Ruijin Huang   +9 more
doaj   +2 more sources

Bilateral descending hypothalamic projections to the spinal trigeminal nucleus caudalis in rats. [PDF]

PLoS ONE, 2013
Several lines of evidence suggest that the hypothalamus is involved in trigeminal pain processing. However, the organization of descending hypothalamic projections to the spinal trigeminal nucleus caudalis (Sp5C) remains poorly understood ...
Khaled Abdallah, Alain Artola, Lénaic Monconduit, Radhouane Dallel, Philippe Luccarini   +4 more
doaj   +1 more source

Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents. [PDF]

PLoS ONE, 2012
Ghrelin is a stomach-derived hormone that regulates food intake and neuroendocrine function by acting on its receptor, GHSR (Growth Hormone Secretagogue Receptor). Recent evidence indicates that a key function of ghrelin is to signal stress to the brain.
Agustina Cabral, Olga Suescun, Jeffrey M Zigman, Mario Perello   +3 more
doaj   +1 more source

Efferent projections of prokineticin 2 expressing neurons in the mouse suprachiasmatic nucleus. [PDF]

PLoS ONE, 2009
The suprachiasmatic nucleus (SCN) in the hypothalamus is the predominant circadian clock in mammals. To function as a pacemaker, the intrinsic timing signal from the SCN must be transmitted to different brain regions.
Chengkang Zhang, Kimberly K Truong, Qun-Yong Zhou   +2 more
doaj   +1 more source

Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors

Metabolites, 2021
In the arcuate nucleus, neuropeptide Y (NPY) neurons, increase food intake and decrease energy expenditure, and control the activity of pro-opiomelanocortin (POMC) neurons, that decrease food intake and increase energy expenditure.
Marilena Marraudino, Elisabetta Bo, Elisabetta Carlini, Alice Farinetti, Giovanna Ponti, Isabella Zanella, Diego Di Lorenzo, Gian Carlo Panzica, Stefano Gotti   +8 more
doaj   +1 more source

Lipopolysaccharide-induced neuronal activation in the paraventricular and dorsomedial hypothalamus depends on ambient temperature. [PDF]

PLoS ONE, 2013
Systemic inflammatory response syndrome is associated with either fever or hypothermia, but the mechanisms responsible for switching from one to the other are unknown.
Samuel P Wanner, Kyoko Yoshida, Vladimir A Kulchitsky, Andrei I Ivanov, Kazuyuki Kanosue, Andrej A Romanovsky   +5 more
doaj   +1 more source