Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice [PDF]
eLife, 2021 Hypersomnolence disorder (HD) is characterized by excessive sleep, which is a common sequela following stroke, infection, or tumorigenesis. HD is traditionally thought to be associated with lesions of wake-promoting nuclei.
Chang-Rui Chen +7 more
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Role of the hypothalamic paraventricular nucleus in anxiety disorders
Stress and Brain, 2022 The hypothalamic paraventricular nucleus (PVN) expresses multiple neuropeptides and plays an essential role in several physiological processes. Among the brain areas directly projecting to the PVN are deep brain structures closely related to instinctive ...
Chen Wu, Mario A. Zetter
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Distinct Hypothalamic Paraventricular Nucleus Inputs to the Cingulate Cortex and Paraventricular Thalamic Nucleus Modulate Anxiety and Arousal [PDF]
Frontiers in Pharmacology, 2022 Insomnia and anxiety are two common clinical diseases that threaten people’s physical and mental health. Insomnia and anxiety may share some similar underlying neural circuit mechanisms in the brain.
Ying Liu +7 more
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Electrophysiological Effects of Ghrelin in the Hypothalamic Paraventricular Nucleus Neurons
Frontiers in Cellular Neuroscience, 2018 The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus.
Raoni C. dos-Santos +5 more
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Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: role of the hypothalamic paraventricular nucleus. [PDF]
PLoS ONE, 2012 The mechanism of cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus (ARCN) was studied in urethane-anesthetized adult male Wistar rats.
Tetsuya Kawabe +2 more
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G Protein-Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models. [PDF]
Obesity (Silver Spring)This study identifies G protein‐coupled receptor 17 (Gpr17) as a novel regulator of leptin and insulin sensitivity. Using complementary knockout models, we demonstrate that Gpr17 deletion enhances energy expenditure, restores leptin responsiveness, and improves insulin sensitivity, revealing Gpr17 as a potential therapeutic GPCR target for obesity and ...
Sun X +8 more
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Immunoreactivity and distribution of Fos in the mouse brain following diverse general anesthetics [PDF]
Scientific ReportsGeneral anesthesia induces a range of effects, including unconsciousness, analgesia, amnesia, and immobility. Despite its widespread use for over a century, the underlying mechanisms remain incompletely understood.
Yiwen Hu +8 more
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Bilateral descending hypothalamic projections to the spinal trigeminal nucleus caudalis in rats. [PDF]
PLoS ONE, 2013 Several lines of evidence suggest that the hypothalamus is involved in trigeminal pain processing. However, the organization of descending hypothalamic projections to the spinal trigeminal nucleus caudalis (Sp5C) remains poorly understood ...
Khaled Abdallah +4 more
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Cytoarchitecture of the human paraventricular hypothalamic nucleus [PDF]
Medicinski pregled, 2009 Introduction. The significance of this research in terms of structure and biochemical processes in PVN contributes to further understanding of vital physiological processes from delivery and stress to delicate chemical processes that keep the hypothalamo-hypophysial axis in balance. Conclusion.
Babović, Siniša S. +5 more
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Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents. [PDF]
PLoS ONE, 2012 Ghrelin is a stomach-derived hormone that regulates food intake and neuroendocrine function by acting on its receptor, GHSR (Growth Hormone Secretagogue Receptor). Recent evidence indicates that a key function of ghrelin is to signal stress to the brain.
Agustina Cabral +3 more
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