Results 121 to 130 of about 444,141 (265)

A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging

Aging Cell, Volume 25, Issue 11, November 2026.
Aging‐associated NAD+ depletion in hypothalamic neurons shortens primary cilia and disrupts CHMP4B trafficking to lysosomes during lysosomal stress, leading to impaired TRPML1–mediated Ca2+ signaling and lysosomal stress responses. Calorie restriction restores hypothalamic NAD+ levels, ciliary structure, and lysosomal homeostasis, thereby improving ...
Se Eun Park, Eun Roh, Jae Woo Park, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Ji Soo Kim, Mun Gyeom Kim, Myeong Ju Kim, Young In Cho, Wontae Jeong, Gil Myoung Kang, Sang‐Yeob Kim, Se Hee Min, Min‐Seon Kim   +15 more
wiley   +1 more source

GABA(B) receptor-activation inhibits GABAergic synaptic transmission in parvocellular neurones of rat hypothalamic paraventricular nucleus

, 2006
The paraventricular nucleus of the hypothalamus contains three classes of neurones: (i) magnocellular and (ii) parvocellular neurosecretory neurones and (iii) nonendocrine projection neurones.
Liu, X., Tribollet, Eliane, Raggenbass, Mario   +2 more
core   +1 more source

Glucose‐dependent insulinotropic polypeptide receptor systems in the hypothalamus and the brainstem regulate feeding and weight through distinct pathways

Journal of Diabetes Investigation
The report by Adriaenssens et al. in JCI Insight 22 May 2023 explored the role and property of the neurons that express glucose‐dependent insulinotropic polypeptide receptor (GIPR) in the brainstem and hypothalamus.
Toshihiko Yada
doaj   +1 more source

Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor

Endocrine Regulations, 2019
Objective. Prolonged treatment with neuroleptics has been shown to induce FosB/ΔFosB expression in several brain regions including the medial prefrontal cortex, dorsomedial and dorsolateral striatum, ventrolateral and dorsolateral septum, nucleus ...
Osacka Jana, Horvathova Lubica, Cernackova Alena, Kiss Alexander   +3 more
doaj   +1 more source

Neuroendorine and epigentic mechanisms subserving autonomic imbalance and HPA dysfunction in the metabolic syndrome

Frontiers in Neuroscience, 2016
Impact of environmental stress upon pathophysiology of the metabolic syndrome (MetS) has been substantiated by epidemiological, psychophysiological, and endocrinological studies.
Erwin eLemche, Oleg S. Chaban, Alexandra V. Lemche   +2 more
doaj   +1 more source

Voluntary exercise mitigates the effects of peri‐adolescent social isolation on emotion recognition and the oxytocinergic system in male mice

Journal of Neuroendocrinology, Volume 38, Issue 11, November 2026.
Abstract Social isolation, particularly during adolescence, is known to affect cognitive, emotional, and social behaviors as well as brain modulatory systems such as the hypothalamic oxytocinergic system. Interestingly, recent evidence indicates that exercise can exert beneficial effects on behaviors through the activation of the oxytocinergic system ...
E. Van Loveren, S. Alfos, S. F. Guu, C. Ducroix‐Crepy, S. Hernández‐Ramírez, G. Ferreira, P. Lafenetre   +6 more
wiley   +1 more source

A hypothalamic circuit links high-fat diet exposure to anxiety-like behavior and anxiety-associated hyperphagia

Nature Communications
Obesity and anxiety disorders are frequently comorbid, yet the neural circuit mechanisms linking metabolic and affective states remain incompletely understood.
Peng Wang, Jun Li, Xin Cheng, Wei Chen, Zhengyu Li, Zheng Fang, Dijia Wang, Bin Mei, Hu Liu, Shaohua Hu, Zhilai Yang, Jiqian Zhang, Gaolin Qiu, Xin Qing, Xuesheng Liu   +14 more
doaj   +1 more source

Life‐long cardiorespiratory consequences of early life stress on estrogen actions in female rats

Journal of Neuroendocrinology, Volume 38, Issue 11, November 2026.
Abstract Early‐life adversity increases risk for disease with sex‐specific effects on brain development. While the association between early‐life stress and neuropsychiatric disorders is well established, its impact on respiratory health is poorly documented, particularly in females.
Richard Kinkead, Stéphanie Fournier, Luana Tenorio‐Lopes, Danuzia Ambrozio‐Marques   +3 more
wiley   +1 more source

Norepinephrine applied in the paraventricular hypothalamic nucleus stimulates vasopressin release

Brain Research, 1986
The present experiments were designed to investigate the effect of norepinephrine (NE) applied directly in the area of the paraventricular nucleus (PVN) of the hypothalamus on arginine-vasopressin (AVP) release and blood pressure. A microinjection of 0.4 micrograms NE in the PNV produced a plasma AVP level of 26.3 +/- 5.3 pg/ml compared to 5.3 +/- 0.6 ...
A, Benetos, I, Gavras, H, Gavras
openaire   +2 more sources

Quantitative histological studies on the hypothalamic paraventricular nucleus in rats: I. Number of cells and synaptic boutons

, 1983
Quantitative histological analysis of serial sections of the adult male rat brain gives mean total estimates of the numbers of cells in the magnocellular and parvicellular divisions of the paraventricular hypothalamic nuclei (PVN) of 6600 and 11,500 ...
Kiss, Jozsef Zoltan, Makara, G. B., Szabo, D., Zaborszky, L., Palkovits, M., Tribollet, Eliane   +5 more
core   +1 more source