Results 1 to 10 of about 318,025 (287)

A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight. [PDF]

, 2013
C1q/TNF-related protein 13 (CTRP13), a hormone secreted by adipose tissue (adipokines), helps regulate glucose metabolism in peripheral tissues. We previously reported that CTRP13 expression is increased in obese and hyperphagic leptin-deficient mice ...
Byerly, Mardi S, McCulloh, Patrick S, Seldin, Marcus M, Swanson, Roy, Wei, Zhikui, Wong, G William   +5 more
core   +21 more sources

Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity

iScience, 2023
Summary: The hypothalamus is a region of the brain that plays an important role in regulating body functions and behaviors. There is a growing interest in human pluripotent stem cells (hPSCs) for modeling diseases that affect the hypothalamus.
Lily Sarrafha, Drew R. Neavin, Gustavo M. Parfitt, Ilya A. Kruglikov, Kristen Whitney, Ricardo Reyes, Elena Coccia, Tatyana Kareva, Camille Goldman, Regine Tipon, Gist Croft, John F. Crary, Joseph E. Powell, Joel Blanchard, Tim Ahfeldt   +14 more
doaj   +1 more source

Complex negative emotions induced by electrical stimulation of the human hypothalamus

Brain Stimulation, 2022
Background: Stimulation of the ventromedial hypothalamic region in animals has been reported to cause attack behavior labeled as sham-rage without offering information about the internal affective state of the animal being stimulated.
Josef Parvizi, Michael J. Veit, Daniel A.N. Barbosa, Aaron Kucyi, Claire Perry, Jonathon J. Parker, Rajat S. Shivacharan, Fengyixuan Chen, Jennifer Yih, James J. Gross, Robert Fisher, Jennifer A. McNab, Jessica Falco-Walter, Casey H. Halpern   +13 more
doaj   +1 more source

Novel Neuroimaging Biomarker for Sleep Quality in Insomnia Disorder: A Hypothalamus Resting State Study

Frontiers in Neuroscience, 2021
Despite striking progress in the understanding of the neurobiology of insomnia disorder (ID), about 40% of ID patients do not reach sustained remission with the primary treatments. It is necessary to reveal novel neuroimaging biomarkers for sleep quality
Shuang Ding, Lijuan Gao, Hanjiaerbieke Kukun, Kai Ai, Wei Zhao, Chao Xie, Yunling Wang   +6 more
doaj   +1 more source

Volume of the hypothalamus and its subunits in patients with episodic migraine without aura during interictal periods. [PDF]

J Headache Pain
Giardina I, Di Renzo A, Chiffi D, Giovannini F, Giuliani G, Sebastianelli G, Casillo F, Abagnale C, Altieri M, Di Piero V, Coppola G, Caramia F.   +11 more
europepmc   +3 more sources

Conserved Genoarchitecture of the Basal Hypothalamus in Zebrafish Embryos

Frontiers in Neuroanatomy, 2020
Analyses of genoarchitecture recently stimulated substantial revisions of anatomical models for the developing hypothalamus in mammalian and other vertebrate systems.
Theresa Schredelseker, Theresa Schredelseker, Wolfgang Driever, Wolfgang Driever   +3 more
doaj   +1 more source

Oleic acid and octanoic acid sensing capacity in rainbow trout Oncorhynchus mykiss is direct in hypothalamus and Brockmann bodies. [PDF]

PLoS ONE, 2013
In a previous study, we provided evidence for the presence in hypothalamus and Brockmann bodies (BB) of rainbow trout Oncorhynchus mykiss of sensing systems responding to changes in levels of oleic acid (long-chain fatty acid, LCFA) or octanoic acid ...
Marta Librán-Pérez, Marcos A López-Patiño, Jesús M Míguez, José L Soengas   +3 more
doaj   +1 more source

Blast Exposure Induces Acute Alterations in Circadian Clock Genes in the Hypothalamus and Pineal Gland in Rats: An Exploratory Study

Neurotrauma Reports, 2023
Blast-induced traumatic brain injury (bTBI) frequently results in sleep and circadian rhythm disturbances. We have investigated whether dysregulation of circadian rhythm after bTBI is mediated by dysregulation of clock genes in the hypothalamus and ...
Manoj Govindarajulu, Mital Y. Patel, Jishnu Krishnan, Joseph B. Long, Peethambaran Arun   +4 more
doaj   +1 more source

Genome-Wide DNA Methylation and Hydroxymethylation Changes Revealed Epigenetic Regulation of Neuromodulation and Myelination in Yak Hypothalamus

Frontiers in Genetics, 2021
Both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are important epigenetic modifications in neurodevelopment. However, there is little research examining the genome-wide patterns of 5mC and 5hmC in brain regions of animals under natural high-
Zhixin Chai, Zhijuan Wu, Qiumei Ji, Jikun Wang, Jiabo Wang, Hui Wang, Chengfu Zhang, Jincheng Zhong, Jinwei Xin   +8 more
doaj   +1 more source

Long-term exercise training down-regulates m6A RNA demethylase FTO expression in the hippocampus and hypothalamus: an effective intervention for epigenetic modification

BMC Neuroscience, 2022
Background Exercise boosts the health of some brain parts, such as the hippocampus and hypothalamus. Several studies show that long-term exercise improves spatial learning and memory, enhances hypothalamic leptin sensitivity, and regulates energy balance.
Shu-Jing Liu, Tong-Hui Cai, Chun-Lu Fang, Shao-Zhang Lin, Wen-Qi Yang, Yuan Wei, Fu Zhou, Ling Liu, Yuan Luo, Zi-Yi Guo, Ge Zhao, Ya-Ping Li, Liang-Ming Li   +12 more
doaj   +1 more source