Results 11 to 20 of about 159,619 (232)
Current Biology, 2014 SummaryThe hypothalamus is one of the oldest and smallest parts of the brain, constituting just 4 gm of the 1400 gm of adult human brain weight. And yet this tiny area contains highly conserved neural circuitry that controls basic life functions: these include energy metabolism, from feeding through digestion, metabolic control, and energy expenditure;
Saper, Clifford B., Lowell, Bradford B.
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The Hypothalamus and Obesity [PDF]
Recent Patents on CNS Drug Discovery, 2006 Obesity has reached epidemic proportions across the developed world. Even though there have been numerous scientific advances in terms of the understanding of the regulation of energy homeostasis, few novel anti-obesity drugs have emerged. Furthermore, those that are available have limited efficacy in producing and maintaining a weight loss beyond 10%.
Joanne A, Harrold, Jason C G, Halford
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Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
Open Life Sciences, 2021 Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine ...
Jiang Dongmei +3 more
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Data-based Model Identification of the Hypothalamus-Pituitary-Thyroid Complex [PDF]
, 2023 The thyroid gland, in conjunction with the pituitary and the hypothalamus, forms a regulated system due to their mutual influence through released hormones. The equilibrium point of this system, commonly referred to as the "set point", is individually determined.
arxiv +1 more source
Frontiers in Cellular Neuroscience, 2020 Huntingtin-associated protein 1 (Hap1) was initially identified as a brain-enriched protein that binds to the Huntington’s disease protein, huntingtin. Unlike huntingtin that is ubiquitously expressed in the brain, Hap1 is enriched in the brain with the ...
Xingxing Chen +13 more
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Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity
iScience, 2023 Summary: The hypothalamus is a region of the brain that plays an important role in regulating body functions and behaviors. There is a growing interest in human pluripotent stem cells (hPSCs) for modeling diseases that affect the hypothalamus.
Lily Sarrafha +14 more
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Frontiers in Neuroanatomy, 2014 The vertebrate embryonic prosencephalon gives rise to the hypothalamus, which plays essential roles in sensory information processing as well as control of physiological homeostasis and behaviour.
Michelle eWare +2 more
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Molecular Brain, 2018 Various mutations in the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene are associated with neurodevelopmental and neuropsychiatric disorders.
Chunmei Jin +6 more
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Stability analysis of a hypothalamic-pituitary-adrenal axis model with inclusion of glucocorticoid receptor and memory [PDF]
AIP Conference Proceedings 1798, 020111, 2017, 2016 This paper analyzes a four-dimensional model of the hypothalamic-pituitary-adrenal (HPA) axis that includes the influence of the glucocorticoid receptor in the pituitary. Due to the spatial separation between the hypothalamus, pituitary and adrenal glands, distributed time delays are introduced in the mathematical model.
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MicroRNAs in the Hypothalamus [PDF]
Neuroendocrinology, 2013 MicroRNAs (miRNAs) are short (∼22 nucleotides) non-coding ribonucleic acid (RNA) molecules that negatively regulate the expression of protein-coding genes. Posttranscriptional silencing of target genes by miRNA is initiated by binding to the 3′-untranslated regions of target mRNAs, resulting in specific cleavage and subsequent degradation of the mRNA ...
Meister, Björn +2 more
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