Results 11 to 20 of about 245,222 (354)

HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus

Nature Metabolism, 2022
The hypothalamus plays a key role in coordinating fundamental body functions. Despite recent progress in single-cell technologies, a unified catalog and molecular characterization of the heterogeneous cell types and, specifically, neuronal subtypes in ...
Lukas Steuernagel, B. Lam, Paul Klemm, G. Dowsett, Corinna A. Bauder, J. Tadross, Tamara Sotelo Hitschfeld, Almudena del Rio Martin, Weiyi Chen, A. J. de Solis, Henning Fenselau, Peter Davidsen, I. Cimino, Sara N. Kohnke, D. Rimmington, A. Coll, A. Beyer, G. Yeo, J. Brüning   +18 more
semanticscholar   +1 more source

Single-cell analysis of the aging female mouse hypothalamus

Nature Aging, 2022
Alterations in metabolism, sleep patterns, body composition and hormone status are all key features of aging. While the hypothalamus is a well-conserved brain region that controls these homeostatic and survival-related behaviors, little is known about ...
Kaitlyn H. Hajdarovic, Doudou Yu, Lexi-Amber Hassell, Shane A. Evans, Sarah Packer, N. Neretti, A. Webb   +6 more
semanticscholar   +1 more source

The Hypothalamus and Obesity [PDF]

Recent Patents on CNS Drug Discovery, 2006
Obesity has reached epidemic proportions across the developed world. Even though there have been numerous scientific advances in terms of the understanding of the regulation of energy homeostasis, few novel anti-obesity drugs have emerged. Furthermore, those that are available have limited efficacy in producing and maintaining a weight loss beyond 10%.
Joanne A, Harrold, Jason C G, Halford
openaire   +3 more sources

Genome-Wide DNA Methylation and Hydroxymethylation Changes Revealed Epigenetic Regulation of Neuromodulation and Myelination in Yak Hypothalamus

Frontiers in Genetics, 2021
Both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are important epigenetic modifications in neurodevelopment. However, there is little research examining the genome-wide patterns of 5mC and 5hmC in brain regions of animals under natural high-
Zhixin Chai, Zhijuan Wu, Qiumei Ji, Jikun Wang, Jiabo Wang, Hui Wang, Chengfu Zhang, Jincheng Zhong, Jinwei Xin   +8 more
doaj   +1 more source

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

Proceedings of the National Academy of Sciences of the United States of America, 1998
We describe a hypothalamus-specific mRNA that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin.
L. Lecea, T. Kilduff, C. Peyron, Xiao-Bing Gao, P. E. Foye, P. Danielson, C. Fukuhara, E. Battenberg, V. Gautvik, F. S. Bartlett, W. Frankel, A. Pol, F. Bloom, K. Gautvik, J. Sutcliffe   +14 more
semanticscholar   +1 more source

Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus

Nature Communications, 2020
The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored.
Xin Zhou, Suijuan Zhong, Honghai Peng, Jing Liu, Wenyu Ding, Le Sun, Qiang Ma, Zeyuan Liu, Ruiguo Chen, Qian Wu, Xiaoqun Wang   +10 more
semanticscholar   +1 more source

Role of hypothalamus function in metabolic diseases and its potential mechanisms [PDF]

PeerJ
The hypothalamus, a crucial neuroendocrine regulatory center, plays a significant role in the occurrence and development of metabolic diseases. Recent advances in molecular biology and imaging technology have facilitated a better understanding of the ...
Xinyu Zhang, Jie Yang, Yilin Li, Yulin Li, Guoqi Li   +4 more
doaj   +2 more sources

A Molecular Census of Arcuate Hypothalamus and Median Eminence Cell Types

Nature Neuroscience, 2017
The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance, fertility and growth through molecularly distinct cell types, many of which remain unknown. To catalog cell types in an unbiased way, we profiled gene expression in 20,921
John N. Campbell, Evan Z. Macosko, Henning Fenselau, T. Pers, A. Lyubetskaya, Danielle E. Tenen, Melissa Goldman, Anne M J Verstegen, J. Resch, S. Mccarroll, E. Rosen, B. Lowell, Linus T. Tsai   +12 more
semanticscholar   +1 more source

Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus

Open Life Sciences, 2021
Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine ...
Jiang Dongmei, Mo Guilin, Jiang Yilong, Kang Bo   +3 more
doaj   +1 more source

Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response

Frontiers in Cellular Neuroscience, 2020
Huntingtin-associated protein 1 (Hap1) was initially identified as a brain-enriched protein that binds to the Huntington’s disease protein, huntingtin. Unlike huntingtin that is ubiquitously expressed in the brain, Hap1 is enriched in the brain with the ...
Xingxing Chen, Xingxing Chen, Xingxing Chen, Ning Xin, Yongcheng Pan, Yongcheng Pan, Louyin Zhu, Peng Yin, Qiong Liu, Qiong Liu, Weili Yang, Xingshun Xu, Shihua Li, Xiao-Jiang Li   +13 more
doaj   +1 more source